Dam, R. Michael van - University of California, Los Angeles

研究领域

My laboratory is interested in making cutting edge molecular imaging methods (e.g. positron emission tomography, PET) more accessible. We are developing improved ways to produce diverse PET tracers at lower cost for research and clinical use. Our research involves developing new automated and miniaturized technologies to streamline all phases of the tracer production process. We also produce tracers for various research groups for imaging of various biological processes (including metabolism, gene expression, cell proliferation, etc.), and we produce labeled peptides and proteins to image receptors and structural proteins with high specificity. We collaborate with several groups on the development of novel PET tracers and on the development of new chemistry approaches for simplified tracer production.

近期论文

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Lazari Mark, Irribarren Jonathan, Zhang Shuang, van Dam R Michael Understanding temperatures and pressures during short radiochemical reactions. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2016; 108: 82-91. Keng Pei Yuin, van Dam R Michael Digital Microfluidics: A New Paradigm for Radiochemistry. Molecular imaging. 2015; 14: 13-14. Lazari Mark, Lyashchenko Serge K, Burnazi Eva M, Lewis Jason S, van Dam R Michael, Murphy Jennifer M Fully-automated synthesis of 16Î²-(18)F-fluoro-5Î±-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2015; 103: 9-14. Sergeev Maxim E, Morgia Federica, Lazari Mark, Wang Christopher, van Dam R Michael Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium. Journal of the American Chemical Society. 2015; 137(17): 5686-94. Lazari Mark, Collins Jeffrey, Shen Bin, Farhoud Mohammed, Yeh Daniel, Maraglia Brandon, Chin Frederick T, Nathanson David A, Moore Melissa, van Dam R Michael Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification. Journal of nuclear medicine technology. 2014; 42(3): 203-10. Tseng Wei-Yu, van Dam R Michael Compact microfluidic device for rapid concentration of PET tracers. Lab on a chip. 2014; 14(13): 2293-302. Cheung Shilin, Ly Jimmy, Lazari Mark, Sadeghi Saman, Keng Pei Yuin, van Dam R Michael The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis. Journal of pharmaceutical and biomedical analysis. 2014; 94(13): 12-8.