Tseng, Hsian-Rong - University of California, Los Angeles

个人简介

Professor, Molecular & Medical Pharmacology Faculty, Crump Institute for Molecular Imaging Member, JCCC Cancer Molecular Imaging

研究领域

Our research interests are to develop microfluidics-based technology platforms and to utilize these technology platforms to address important issues in the fields of molecular imaging, cancer biology and chemistry. In contrast to conventional bench-top setups, microfluidics has been used to manipulate chemical and biological processes on nanoliter (nL) to microliter (mL) scales with the profound advantages of enhanced heat transfer performance, faster diffusion time and reaction kinetics, as well as improved control over experimental conditions. By incorporating integrated microvalves into microfluidic batch systems, the integrated microfluidic platforms enable the execution and automation of multiple, parallel, and/or sequential chemical or biological processes on a single chip under digital control. For the past two years, we have been working with several research groups who have expertise covering molecular imaging, cancer biology, immunology and pathology to develop a variety of functioning microfluidic platforms for applications in three major areas of interest: (i) Development of Molecular Imaging Probes (ii) Biological Analysis (iii) Production of Nanostructured Materials In a boarder playing field, our goal remains the creation of further integrated microfluidic technology platforms for the broader space in chemistry and biology beyond a single functioning platform on a chip. We will compile many different microfluidic platforms to produce a number of game systems: "Let's Play _____", where the blank is "systems biology of disease", "biomarkers", "pharmacology", "biochemical reaction kinetics", "chemistry" and "cancer diagnosis" etc. where execution is rapid and learning curves are steep.

近期论文

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Zhao Libo, Tang Chuanhao, Xu Li, Zhang Zhen, Li Xiaoyan, Hu Haixu, Cheng Si, Zhou Wei, Huang Mengfei, Fong Anna, Liu Bing, Tseng Hsian-Rong, Gao Hongjun, Liu Yi, Fang Xiaohong Enhanced and Differential Capture of Circulating Tumor Cells from Lung Cancer Patients by Microfluidic Assays Using Aptamer Cocktail. Small (Weinheim an der Bergstrasse, Germany). 2016; 12(8): 1072-81. Liu Yang, Du Juanjuan, Choi Jin-Sil, Chen Kuan-Ju, Hou Shuang, Yan Ming, Lin Wei-Yu, Chen Kevin Sean, Ro Tracy, Lipshutz Gerald S, Wu Lily, Shi Linqi, Lu Yunfeng, Tseng Hsian-Rong, Wang Hao A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors. Angewandte Chemie (International ed. in English). 2016; 55(1): 169-73. Hou Shuang, Choi Jin-Sil, Garcia Mitch Andre, Xing Yan, Chen Kuan-Ju, Chen Yi-Ming, Jiang Ziyue K, Ro Tracy, Wu Lily, Stout David B, Tomlinson James S, Wang Hao, Chen Kai, Tseng Hsian-Rong, Lin Wei-Yu Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry. ACS nano. 2016; 10(1): 1417-24. Jiang Runze, Lu Yi-Tsung, Ho Hao, Li Bo, Chen Jie-Fu, Lin Millicent, Li Fuqiang, Wu Kui, Wu Hanjie, Lichterman Jake, Wan Haolei, Lu Chia-Lun, OuYang William, Ni Ming, Wang Linlin, Li Guibo, Lee Tom, Zhang Xiuqing, Yang Jonathan, Rettig Matthew, Chung Leland W K, Yang Huanming, Li Ker-Chau, Hou Yong, Tseng Hsian-Rong, Hou Shuang, Xu Xun, Wang Jun, Posadas Edwin M A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer. Oncotarget. 2015; 6(42): 44781-93. Rim You Seung, Bae Sang-Hoon, Chen Huajun, Yang Jonathan L, Kim Jaemyung, Andrews Anne M, Weiss Paul S, Yang Yang, Tseng Hsian-Rong Printable Ultrathin Metal Oxide Semiconductor-Based Conformal Biosensors. ACS nano. 2015; 9(12): 12174-81. Chen Jie-Fu, Ho Hao, Lichterman Jake, Lu Yi-Tsung, Zhang Yang, Garcia Mitch A, Chen Shang-Fu, Liang An-Jou, Hodara Elisabeth, Zhau Haiyen E, Hou Shuang, Ahmed Rafi S, Luthringer Daniel J, Huang Jiaoti, Li Ker-Chau, Chung Leland W K, Ke Zunfu, Tseng Hsian-Rong, Posadas Edwin M Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases. Cancer. 2015; 121(18): 3240-51. Hou Shuang, Choi Jin-sil, Chen Kuan-Ju, Zhang Yang, Peng Jinliang, Garcia Mitch A, Yu Jue-Hua, Thakore-Shah Kaushali, Ro Tracy, Chen Jie-Fu, Peyda Parham, Fan Guoping, Pyle April D, Wang Hao, Tseng Hsian-Rong Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells. Small (Weinheim an der Bergstrasse, Germany). 2015; 11(21): 2499-504.