Edgerton, V. Reggie - University of California, Los Angeles

个人简介

Dr. Edgerton received his Ph.D. in Exercise Physiology from Michigan State University, Masters from University of Iowa and BS from East Carolina University. He is currently the Director of the Neuromuscular Research Laboratory and a Distinguished Professor of the Departments of Integrative Biology and Physiology, Neurobiology and Neurosurgery. He has been teaching and conducting research at UCLA for over 40 years. His research is focused on how the neural networks in the lumbar spinal cord of mammals, including humans, regain control of standing, stepping and voluntary control of fine movements after paralysis, and how can these motor functions be modified by chronically imposing activity-dependent interventions after spinal cord injury.

研究领域

Dr. Edgerton’s laboratory focuses on two main research questions: 1. How do the neural networks in the lumbar spinal cord of mammals, including humans, regain control of standing, stepping and voluntary control of fine movements after paralysis? 2. How can these motor functions be modified by imposing activity-dependent interventions after spinal cord injury? These studies have shown that the mammalian spinal cord, without any input from the brain, can learn, forget, and relearn specific complex motor tasks such as standing and stepping. We now have three effective ways to neuromodulate the spinal cord to improve and regain function: 1. Stimulation of the spinal circuitry using electrical current: Invasive and Non-Invasive 2. Administration of pharmacological agents 3. Repetitive training of motor tasks.

近期论文

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Kim, Jung A., Roland R. Roy, Hui Zhong, William A. Alaynick, Emi Embler, Claire Jang, Gabriel Gomez, Takuma Sonoda, Ronald M. Evans, and V. Reggie Edgerton. “Pparδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection.” Muscle & nerve (2015). Sayenko, Dimitry G., Darryn A. Atkinson, Christine J. Dy, Katelyn M. Gurley, Valerie L. Smith, Claudia A. Angeli, Susan J. Harkema, V. Reggie Edgerton, and Yury P. Gerasimenko. “Spinal segment-specific transcutaneous stimulation differentially shapes activation pattern among motor pools in humans.” Journal of Applied Physiology (2015): jap-01128. Alam, Monzurul, Guillermo Garcia-Alias, Prithvi K. Shah, Yury Gerasimenko, Hui Zhong, Roland R. Roy, and V. Reggie Edgerton. “Evaluation of optimal electrode configurations for epidural spinal cord stimulation in cervical spinal cord injured rats.” Journal of neuroscience methods 247 (2015): 50-57. Duru, Paul O., Niranjala JK Tillakaratne, Jung A. Kim, Hui Zhong, Stacey M. Stauber, Trinh T. Pham, Mei S. Xiao, V. Reggie Edgerton, and Roland R. Roy. “Spinal neuronal activation during locomotor‐like activity enabled by epidural stimulation and 5‐hydroxytryptamine agonists in spinal rats.” Journal of neuroscience research (2015). García-Alías, Guillermo, Kevin Truong, Prithvi K. Shah, Roland R. Roy, and V. Reggie Edgerton. “Plasticity of subcortical pathways promote recovery of skilled hand function in rats after corticospinal and rubrospinal tract injuries.”Experimental neurology 266 (2015): 112-119. Lavrov, Igor, Pavel E. Musienko, Victor A. Selionov, Sharon Zdunowski, Roland R. Roy, V. Reggie Edgerton, and Yury Gerasimenko. “Activation of spinal locomotor circuits in the decerebrated cat by spinal epidural and/or intraspinal electrical stimulation.” Brain research 1600 (2015): 84-92.