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Dynamic systems biology modeling and simulation Human disease models, their dynamics and optimal control (treatment) Physiological, pharmacological and toxicological systems applications

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Joseph DiStefano III, “Pizza alla DiStefano,” (a family recipe) Sunset Magazine, 130:184, Lane Magazine Co., Menlo Park, CA., March 1963. Joseph DiStefano III, “Design for a Digitally-Rebalanced Closed-Loop Velocity Meter Providing a Discrete Output,” IEEE Transactions on Aerospace, AS-2:1059-1064, 1964. Joseph DiStefano III, “The Choice of State Variables for the Determination of the Stability of Nonlinear Systems Utilizing the Second Method of Liapunov,” IEEE Transactions on Automatic Control, AC- 9:279:280, 1964. Joseph DiStefano III, E.B. Stear & G. P. Moore, “A Model of the Thyroid Hormone Regulator and a Proposal for Its Experimental Validation,” In Proceedings of the 19th Annual Conf. on Engineering in Medicine and Biology, 8:3, 1966. Joseph DiStefano III, and E. B. Stear, “Neuroendocrine Control of Thyroid Secretion in Living Systems: a Feedback Control System Model,” Bulletin, Math. Biophysics, 30:3-26, 1968. Joseph DiStefano III, and E. B. Stear, “On Identification of Hypothalamo-Hypophysial Control and Feedback Relationships with the Thyroid Gland,” Journal of Theoretical Biology, 19:29-50, 1968. Joseph DiStefano III, “Endocrine Regulation: Models and Experimental Design for System Identification,” Proceedings, Seminar on Large Scale Systems in the Mathematical Biosciences, Dubrovnik, Yugoslavia, 1968. Joseph DiStefano III, “A Model of the Regulator of Circulating Thyroxin Unbound and Bound to Plasma Proteins and Its Response to Pregnancy, Drugs, Long Acting Thyroid Stimulator and Temperature Stress,” Math. Biosci. 4:137-152, 1969. Joseph DiStefano III, and E. B. Stear, “Modeling and Control Aspects of Thyroid Function,” Proceedings, Conference on Hormonal Control Systems in Health and Disease, Supplement 1, Math. Biosci., American Elsevier Publishing Co., New York, 1969.

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