Wang, Cunyu - University of California, Los Angeles

个人简介

Education B.D.S., Stomatology, Nanjing Medical University, 1985 D.D.S., Pediatric Dentistry, Peking University School of Dentistry, 1989 Postdoctoral, Immunology and Cytokine Biology, Forsyth Institute, 1995 Ph.D., Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 1998 Awards and Recognitions Member, Institute of Medicine of National Academies, 2011 AAAS Fellow, 2011 Distinguished Scientist Award for Basic Research in Biological Mineralization, International Association for Dental Research, 2013 No-Hee Park Endowed Professor in Dentistry, 2009 Distinguished Scientist Award for Oral Pathology and Medicine, International Association for Dental Research, 2009

研究领域

Molecular Signaling (NF-κB and Wnt) Tumor-invasive growth and Metastasis Adult mesenchymal stem cells, dental stem cells and regenerative medicine Inflammation and innate immunity

近期论文

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Ding X., Pan H., Li. J., Zhong Q., Chen X., Dry S.M., Wang C.Y., “Epigenetic activation of AP-1 promotes squamous cell carcinoma metastasis.” Science Signaling, 2013 in press. Bianco P., Cao X., Frenette P.S., Mao J.J., Robey P.G., Simmons P.J., Wang C.Y., “The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine.” Nat Med. 2013 Jan;19(1):35-42. Epub 2013 Jan 7. Ye L., Fan Z., Yu b., Chang J., Al Hezaimi K., Zhou X., Park N.H., Wang C.Y., “Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.” Cell Stem Cell. 2012 Jul 6;11(1):50-61 Zhao B., Li L., Wang L., Wang C.Y., Yu J., Guan K.L., “Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.” Genes Dev. 2012 Jan 1;26(1):54-68. Krum S.A., Chang J., Miranda-Carboni G., Wang C.Y. “Novel functions for NFκB: inhibition of bone formation.” Nat Rev Rheumatol. 2010 Oct:6(10):607-11 Song H., Mak K.K., Topol L., Yun K., Hu J., Garrett L., Chen Y., Park O., Chang J., Simpson R.M., Wang C.Y., Gao B., Jiang J., Yang Y. “Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.” Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1431-6. Fan Z., Yamaza T., Lee J.S., Yu J., Wang S., Fan G., Shi S., Wang C.Y. “BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.” Nat Cell Biol. 2009 Aug:11(8):1002-9. Chang J., Wang Z., Tang E., Fan Z., McCauley L., Franceschi R., Guan K., Krebsbach P.H., Wang C.Y. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 2009 Jun:15(6):682-9. Li J., Wang C.Y., “TBL-1TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.” Nat Cell Biol. 2008 Feb:10(2):160-9. Park B.K., Zhang H., Zeng Q., Dai J., Keller E.T., Giordano T., Gu K., Shah V., Pei L., Zarbo R.J., McCauley L., Shi S., Chen S., Wang C.Y. “NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF.” Nat Med 2007 Jan:13(1):62-9.