Seidlits, Stephanie - University of California, Los Angeles

个人简介

Education B.S., Rice University, 2004 M.S., University of Texas, Austin, 2006 Ph.D., University of Texas, Austin, 2010 Postdoctoral Fellow, Northwestern University, 2010-2014. Awards & Recognitions National Science Foundation CAREER award, 2017 NIH NRSA F32 Fellowship for Post-Doctoral Training, 2012-2014 Best Poster Award (A large-scale, real-time array to assess dynamic changes in intracellular signaling in response to biomaterial-mediated mechanical and adhesive stimuli) in Design of Cell-Instructive Materials Symposium at Materials Research Society Meeting, San Fransisco, CA, 2013 Institute for BioNanotechnology in Medicine-Baxter Early Career Award, Northwestern University, 2010-2012 Rice University Outstanding Bioengineering Undergraduate Alumna, 2011 Completion of Graduate Portfolio in Cellular and Molecular Imaging for Diagnostics and Therapeutics, University of Texas, Austin, 2010 Cockrell School of Engineering THRUST 2000 Fellowship Award, University of Texas, Austin, 2006-2010 P.E.O. (Philanthropic Education Organization) International Graduate Scholar Award, 2007-2008 NSF IGERT Fellowship in Cellular and Molecular Imaging for Diagnostics and Therapeutics, University of Texas, Austin, 2004-2006

研究领域

Focused at the interface of engineering, neuroscience and medicine, our research seeks to develop clinical therapies for central nervous system (CNS) injury and disorders, including spinal cord injury, traumatic brain injury and glioma formation. Using biomaterial microenvironments and advanced imaging tools, we aim to identify differences between the extracellular environment of diseased and healthy or developing and adult CNS tissues and exploit these mechanistic discoveries to develop novel therapies that target the local environment. Engineered microenvironments enable ex vivo investigation of key physiological players within conditions that approximate those in vivo so that physiologically relevant data can be obtained in a simplified context. Ultimately, this approach enables the development of new therapeutic strategies based on controlled manipulation of these players. The long-term goal of this research is to translate biomaterial microenvironments to in vivo regenerative therapies using hydrogels, gene and protein delivery and cell replacement as building blocks.

近期论文

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C.M. Walthers, S.K. Seidlits. (2015) Gene delivery strategies for spinal cord repair. Biomarkers Insights, Suppl 1: 11-29. A.M. Thomas*, S.K. Seidlits*, (co-first authors*), A.G. Goodman, T.V. Kukushliev, D.M. Hassani, B.J. Cummings, A.J. Anderson, L.D. Shea. (2014) Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integrative Biology 6(7):694-705 S.K. Seidlits, K.A. Hlavaty, L.D. Shea. (2014) “DNA delivery for regeneration” in Biomaterials and Regenerative Medicine, ed. P.X. Ma. Cambridge University Press, Cambridge, MA. S.K. Seidlits, R.M. Gower, J.A. Shepard, L.D. Shea. (2013) Hydrogels for lentiviral gene delivery. Expert Opinion on Drug Delivery, 10(4):499-509. A.M. Thomas, M.B. Kubilius, S.J. Holland, S.K. Seidlits, R.M. Boehler, A. J. Anderson, B.J. Cummings, L.D. Shea. (2013) Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury. Biomaterials 34(9):2213-2220. Z.Z. Khaing, B.D. Milman, J.E. Vanscoy, S.K. Seidlits, R.J. Grill, C.E. Schmidt. (2011) High MW hyaluronic acid limits astrocyte proliferation and scar formation after SCI. J. Neural Eng. 8(4):046033. S.K. Seidlits, C.T. Drinnan, R.R. Petersen, J.B. Shear, L.J. Suggs, C.E. Schmidt. (2011) Fibronectin-hyaluronic acid composites for three-dimensional endothelial cell culture. Acta Biomaterialia 7(6):2401-2409. Y. Yang, S.K. Seidlits, M.M. Adams, Lynch VM, C.E. Schmidt, E.V. Ansyln, J.B. Shear. (2010) A highly selective low-background fluorescent imaging agent for nitric oxide. J. Am. Chem. Soc. 132(38):13114-13116. S.K. Seidlits*, Z.Z. Khaing*, (co-first authors*) R.R. Petersen, J.D. Nickels, J.E. Vanscoy, J.B. Shear†, C.E. Schmidt† (co-corresponding authors†). (2010) The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation. Biomaterials 31:3930-3940. S.K. Seidlits, C.E. Schmidt*, J.B. Shear* (co-corresponding authors*). (2009) High-resolution patterning of hydrogels in three dimensions using direct-write photofabrication for cell guidance. Adv. Funct. Mater. 19:3543-3551.