个人简介
Education
2004 Post Doctoral Fellow; Swiss Federal Institute of Technology Lausanne, Ecublens, Switzerland
2004 Ph.D., Northwestern University, Evanston, IL.
1999 B.S., University of California Berkeley, CA.
Awards
American Society of Gene Therapy Young Investigator Award, 2009
NSF CAREER award “Hydrogels for Matrix-Tethered Gene Delivery”, 2008
NRSA Postdoctoral Fellow, 2004
Dissertation Henderson Fellowship, Northwestern University, 2003
National Institutes of Health Predoctoral Biotechnology Training Grant, 2001
研究领域
Biomaterials
Non-viral Gene Delivery
近期论文
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Sideris E, Griffin DR, Ding Y, Li S, Weaver WM, Di Carlo D, Hsiai T, Segura T. Particle Hydrogels Based on Hyaluronic Acid Building Blocks ACS Biomat Sci. Eng. 2016 Sept 7; 2(11):2034-2041.
Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Carmichael ST, Segura T. Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach. Data Brief. 2016 Nov 24;10:202-209.
Li J, Zhang L, Liu Y, Wen J, Wu D, Xu D, Segura T, Jin J, Lu Y, Wang H. An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules. Chem Commun (Camb). 2016 Nov 15;52(93):13608-13611.
Moshayedi P, Nih LR, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Biomaterials. 2016 Oct;105:145-55.
Zhu X, Gojgini S, Chen TH, Teng F, Fei P, Dong S, Segura T, Ho CM. Three dimensional tubular structure self-assembled by vascular mesenchymal cells at stiffness interfaces of hydrogels. Biomed Pharmacother. 2016 Oct;83:1203-1211.
Darling NJ, Hung YS, Sharma S, Segura T. Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels. Biomaterials. 2016 Sep;101:199-206.
Nih LR, Carmichael ST, Segura T. Hydrogels for brain repair after stroke: an emerging treatment option. Curr Opin Biotechnol. 2016 Aug;40:155-63.
Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A. Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nat Commun. 2016 Aug 1;7:12348.
Stavrakis AI, Zhu S, Hegde V, Loftin AH, Ashbaugh AG, Niska JA, Miller LS, Segura T, Bernthal NM. In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating. J Bone Joint Surg Am. 2016 Jul 20;98(14):1183-9.
Zhu S, Segura T. Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis. Ann Biomed Eng. 2016 Jun;44(6):1983-92.
Lesher-Perez SC, Segura T, Moraes C. Getting there is half the battle: recent advances in delivering therapeutics. Integr Biol (Camb). 2016 Jan;8(1):8-11.