Carlo, Dino Di - University of California, Los Angeles

个人简介

Education B.S., University of California, Berkeley, 2002 Ph.D., University of California, Berkeley and San Francisco, 2006 Postdoctoral Training with Professor Mehmet Toner, Harvard Medical School, Massachusetts General Hospital, Center for Engineering in Medicine, 2006-2008 Awards and Recognitions Presidential Early Career Award for Scientists and Engineers (PECASE), 2016 Elected Fellow of the American Institute of Medical and Biological Engineering (AIMBE), 2016 Materials Research Society Outstanding Young Investigator Award, 2016 Pioneers of Miniaturization Prize, 2015 Elected Fellow of the Royal Society of Chemistry (FRSC), 2015 Analytical Chemistry Young Innovator Award, 2014 NSF CAREER Award, 2012 ONR Young Investigator Award, 2012 Packard Fellow, 2011 DARPA Young Faculty Award, 2011 NIH Director’s New Innovator Award, 2010 Coulter Translational Research Award, 2010 Postdoctoral Fellowship, American Cancer Society, 2007 – 2009 Best Poster Award (for work on large scale single cell analysis in microfluidics), Micro Total Analysis Systems Conference, Boston, 2005 Whitaker Foundation Graduate Fellowship, 2002 – 2006 MESA Fellow, Sandia National Laboratories, 2002 – 2003 Bioengineering Department Citation (one award given annually), 2001

研究领域

We are exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. Current research is focused on: (i) Quantitative cell biology and mechanics of cancer metastasis. Microfluidic methods to control the surface chemistry, mechanical, and soluble environment are well suited to address questions associated with cell migration and movement. We are particularly interested in the process of cancer metastasis and intravasation. (ii) Nonlinear microfluidics. Nonlinear fluid dynamic effects are usually not considered in microfluidic systems but may provide simple methods to manipulate and sort rare populations of cells at high-throughputs. We are studying the physical basis of inertial migration of particles and engineering novel portable and robust diagnostic and analysis systems using this phenomenon for applications in the developed and developing world. (iii) Microfluidic directed cellular evolution. Microfluidic technologies may offer advantages in creating new useful selection criteria for cellular evolution. Besides gaining an understanding of dominant molecular pathways in controlling these behaviors, the resultant evolved cell populations and genetic modifications may be useful for therapeutic applications.

近期论文

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Biophysical isolation and identification of circulating tumor cells. Che J, Yu V, Garon EB, Goldman JW, Di Carlo D. Lab Chip. 2017 Apr 11;17(8):1452-1461. doi: 10.1039/c7lc00038c. PMID: 28352869 Highly Stable and Sensitive Nucleic Acid Amplification and Cell-Phone-Based Readout. Kong JE, Wei Q, Tseng D, Zhang J, Pan E, Lewinski M, Garner OB, Ozcan A, Di Carlo D. ACS Nano. 2017 Mar 28;11(3):2934-2943. doi: 10.1021/acsnano.6b08274. Epub 2017 Mar 2. Modulating motility of intracellular vesicles in cortical neurons with nanomagnetic forces on-chip. Kunze A, Murray CT, Godzich C, Lin J, Owsley K, Tay A, Di Carlo D. Lab Chip. 2017 Feb 28;17(5):842-854. doi: 10.1039/c6lc01349j. PMID: 28164203