Geacintov, Nicholas E. - New York University

个人简介

B.S. (physical and polymer chemistry), SUNY; M.S. (physical and polymer chemistry) Syracuse; Ph.D. (physical and polymer chemistry) Syracuse; Postdoctoral research at Brooklyn Polytechnic Institute

研究领域

The overall objective is to understand the mechanisms and consequences of damage in DNA, either free or wrapped around histone octamers in nucleosomes, induced by environmental contaminants and other reactive chemical species employing well defined model systems.

近期论文

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Reeves DA, Mu H, Kropachev K, Cai Y, Ding S, Kolbanovskiy A, Kolbanovskiy M, Chen Y, Krzeminski J, Amin S, Patel DJ, Broyde S, Geacintov NE. Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions. Nucleic Acids Res. 2011, 39(20): 8752-64. Liu Y, Reeves D, Kropachev K, Cai Y, Ding S, Kolbanovskiy M, Kolbanovskiy A, Bolton JL, Broyde S, Van Houten B, Geacintov NE. Probing for DNA damage with β-hairpins: Similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro. DNA Repair (Amst), 2011, 10(7):684-96. PMID: 21741328. Cai Y, Wang L, Ding S, Schwaid A, Geacintov NE, Broyde S. A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorigen stabilizes nucleosome core particle structure. Biochemistry, 2011, 23;49(46):9943-5. PMID:20964331. Cai Y, Ding S, Geacintov NE, Broyde S.Intercalative conformations of the 14R (+)- and 14S (-)-trans-anti-DB[a,l]P-N⁶-dA adducts: molecular modeling and MD simulations. Chem Res Toxicol. 2011, 24(4):522-31. PMID: 21361377. Krzeminski J, Kropachev K, Kolbanovskiy M, Reeves D, Kolbanovskiy A, Yun BH, Geacintov NE, Amin S, El-Bayoumy K. Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene. Chem Res Toxicol. 2011, 24(1):65-72. PMID: 21114286. Lee YA, Liu Z, Dedon PC, Geacintov NE, Shafirovich V. Solvent Exposure Associated with Single Abasic Sites Alters the Base Sequence Dependence of Oxidation of Guanine in DNA in GG Sequence Contexts. ChemBiochem. 2011, 12(11):1731-9. PMID:21656632. Yun BH, Geacintov NE, Shafirovich V. Generation of guanine-thymidine cross-links in DNA by peroxynitrite/ carbon dioxide. Chem Res Toxicol. 2011, 24(7):1144-52. Hendel A, Krijger PH, Diamant N, Goren Z, Langerak P, Kim J, Reissner T, Lee KY, Geacintov NE, Carell T, Myung K, Tateishi S, D'Andrea A, Jacobs H, Livneh Z. PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells. PLoS Genet. 2011 Sep; 7(9):e1002262. Rechkoblit O, Kolbanovskiy A, Malinina L, Geacintov NE, Broyde S, Patel DJ. Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4. Nature Struct Mol Biol. 2010 (3):379-88. PubMed PMID: 20154704. Dreij K, Rhrissorrakrai K, Gunsalus KC, Geacintov NE, Scicchitano DA. Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Carcinogenesis. 2010 (6):1149-57. PMID: 20382639. Shao J, Geacintov NE, Shafirovich V. Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds. J Phys Chem B. 2010, 114(19):6685-92. PMID: 20415485. Yun BH, Dedon PC, Geacintov NE, Shafirovich V. One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection. Photochem Photobiol. 2010 ;86(3):563-70. PMID: 20408978. Shao J, Geacintov NE, Shafirovich V. Oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine by oxyl radicals produced by photolysis of azo compounds. Chem Res Toxicol. 2010, 17;23(5):933-8. PMID: 20408566. Cai Y, Kropachev K, Xu R, Tang Y, Kolbanovskii M, Kolbanovskii A, Amin S, Patel DJ, Broyde S, Geacintov NE. Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion. J Mol Biol. 2010, 399(3):397-409. PMID: 20399214. Zheng H, Cai Y, Ding S, Tang Y, Kropachev K, Zhou Y, Wang L, Wang S, Geacintov NE, Zhang Y, Broyde S. Base Flipping Free Energy Profiles for Damaged and Undamaged DNA. Chem Res Toxicol. 23, 1868–1870 PMID: 21090780 Cai Y, Wang L, Ding S, Schwaid A, Geacintov NE, Broyde S. A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorogen stabilizes nucleosome core particle structure. Biochemistry 2010, 49(46):9943-5. PMID: 20964331 Cai Y, Patel DJ, Broyde S, Geacintov NE. Base sequence context effects on nucleotide excision repair. J Nucleic Acids. 2010. PMID: 20871811 Jia L, Geacintov NE, Broyde S. The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions. Nucleic Acids Res. 36(20):6571-84 (2008). PMID: 18931375. Margolin Y, Shafirovich V, Geacintov NE, DeMott MS, Dedon PC. DNA sequence context as a determinant of the equantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron produced by hydroxyl radicals and one-electron oxidants. J Biol Chem. 283(51):35569-78 (2008). PMID: 18948263. Cai Y, Patel DJ, Geacintov NE, Broyde S. Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals. J Mol Biol. 385(1): 30-44 (2009). PMID: 18948114. Kropachev K, Kolbanovskii M, Cai Y, Rodríguez F, Kolbanovskii A, Liu Y, Zhang L, Amin S, Patel D, Broyde S, Geacintov NE. The Sequence Dependence of Human Nucleotide Excision Repair Efficiencies of Benzo[a]pyrene-derived DNA Lesions: Insights into the Structural Factors that favor Dual Incisions. J Mol Biol. 386(5):1193-203 (2009). PMID: 19162041