null - 台湾清华大学

个人简介

Massachusetts Institute of Technology(USA)(Ph.D.) (1982) National Taiwan University(M.S.) (1977)

近期论文

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Koeller, K., Wong, C.-H. “Enzymes for chemical synthesis”, Nature (2001) 409, 232. Ritter, T.K., Wong, C.-H. “Carbohydrate-based antibiotics: a new approach to tackle the problem of antibiotic resistance”, Angew. Chem. Int. Ed. (2001) 40, 3508. Sears, P., Wong, C.-H. “Towards automated synthesis of oligosaccharides and glycoproteins”, Science (2001) 291, 2344. Wu, C.-Y., Chang, C.-F., Chen, J.S.-Y., Wong, C.-H., Lin, C.-H, “Rapid Diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective fucosidase inhibitors”, Angew. Chem. Int. Ed. (2003) 42, 4661. Zhang, Z., Gildersleeve J., Yang, Y.-Y., Xu, R., Loo, J. A., Uryu, S., Wong, C. –H., Schultz, P. G. “A new strategy for the synthesis of glycoproteins”, Science (2004) 303, 371. Bryan, M.C., Fazio, F., Lee, H.-K., Huang, C.-Y., Chang, A., Best, M.D., Calarese, D.A., Blixt, O., Paulson, J.C., Burton, D., Wilson, I.A., Wong, C.-H. “Covalent display of oligosaccharide arrays in microtiter plates”, J. Am. Chem. Soc. (2004), 126, 8640. Hsu, H.-Y., Hua, K.-F., Lin, C.-C., Lin, C.-H., Wong, C.-H. “Extract of Reishi polysaccharides induces cytokine expression via toll-like receptor 4-modulated protein kinase signaling pathways”, J. Immunol. (2004), 173, 5989. Wu, C.-Y., Jan, J.-T., Ma, H.-H., Kuo, C.-J., Juan, H.-F., Cheng, Y.-S. E., Hsu, H.-H., Huang, H.-C., Wu, D., Brik, A., Liang, F.-S., Liu, R.-S., Fang, J.-M., Chen, S.-T., Liang, P.-H., Wong, C.-H. “Small molecules targeting severe acute respiratory syndrome (SARS) human coronavirus”, Proc. Natl. Acad. Sci. U.S.A. (2004), 101, 10012. Xu, R., Hanson, S.R., Zhang, Z., Yang, Y.-Y., Schultz, P.G., Wong, C.-H. “Site-specific incorporation of the mucin-type N-acetylgalactosamine-α-O-threonine into protein in Escherichia coli”, J. Am. Chem. Soc. (2004), 126, 15654. Blixt, O., Head, S., Mondala, T., Scanlan, C., Huflejt, M.E., Alvarez, R., Bryan, M.C., Fazio, F., Calarese, D., Stevens, J., Razi, N., van Die, I., Burton, D., Wilson, I.A., Cummings, R., Bovin, N., Wong, C.-H., Paulson, J.C. “Printed covalent glycan array for ligand profiling of diverse glycan binding proteins”, Proc. Natl. Acad. Sci. U.S.A. (2004),101, 17033. Chen, J. H., Chang, Y.-W., Yao, C.-W., Chiueh, T.-S., Huang, S.-C., Chien, K.-Y., Chen, A., Chang, F.-Y., Wong, C.-H., Chen, Y.-J. “Plasma proteome of severe acute respiratory syndrome (SARS) analyzed by two-dimensional gel eletrophoresis and mass spectrometry”, Proc. Natl. Acad. Sci. U.S.A. (2004), 101, 17039. Lee, J. C.; Wu, C. Y.; Apon, J. V.; Siuzdak, G..; Wong, C. H., Reactivity-based one-pot synthesis of tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array. Angew Chem Int Ed Engl 2006, 45, 2753-7. Brik, A.; Yang, Y. Y.; Ficht, S.; Wong, C. H., Sugar-Assisted Glycopeptide Ligation. J Am Chem Soc 2006, 128, 5626-7. Fujio, M.; Wu, D.; Garcia-Navarro, R.; Ho, D.D.; Tsuji, M.; Wong, C. H., Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity. J Am Chem Soc 2006, 128, 9022-3. Sawa, M.; Hsu, T. L.; Itoh, T.; Sugiyama, M.; Hanson, S. R.; Vogt, P. K.; Wong,C. H., Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Proc Nat Acad Sci USA 2006, 103, 12371-6 Hsu, N. Y.; Yang, W. B.; Wong, C. H.; Lee, Y. C.; Lee, R. T.; Wang, Y. S.; Chen, C. H., Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. Rapid Commun Mass Spectrom 2007, 21, (13), 2137-46. Hsu, T. L.; Hanson, S. R.; Kishikawa, K.; Wang, S. K.; Sawa, M.; Wong, C. H., Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells. Proc Natl Acad Sci U S A 2007, 104, (8), 2614-2619. Chang, Y. J.; Huang, J. R.; Tsai, Y. C.; Hung, J. T.; Wu, D.; Fujio, M.; Wong, C. H.; Yu, A. L., Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids. Proc Natl Acad Sci U S A 2007, 104, (25), 10299-304. Ficht, S.; Payne, R. J.; Brik, A.; Wong, C. H., Second Generation Sugar-Assisted Ligation: An Effective New Method for the Synthesis of Cysteine-Containing Glycopeptides. Angew Chem Int Ed 2007, 46 (31): 5975-5979. Hanson, S. R.; Hsu, T. L.; Weerapana, E.; Kishikawa, K.; Simon, G. M.; Cravatt, B. F.; Wong, C. H., Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. J Am Chem Soc 2007, 129, (23), 7266-7.