个人简介

Ph.D. (1982), Stanford University, U.S.A. B.S. in Chemistry (1976), National Taiwan University

研究领域

Bionano Sciences & Technology, Gene Therapy, Organic Synthesis and Reactions, Silicon Chemistry, as well as Polymer Science

1. Development of new drugs for anti-cancer,anti-virus,and anti-bacteria; 2. Synthesis of biologically active compounds and natural products; 3. Development of new synthetic methods and strategies; 4. Synthesis of novel nano-biomaterials and nano-polymerts; 5. Development of organosilicon reagents and new silicon reactions for "Green Chemistry;" 6. Establishment of the concept and utilization of "counterattack reagents;" and 7. Development of novel DNA-and RNA-cleaving agents.

近期论文

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1.Hwu, J.-R.; Singha, R.; Hong, S.-C.; Chang, Y.-H.; Das, A.-R.; Vliegen, I.; De Clercq, E.; Neyts, J. “Synthesis of New Benzimidazole-Coumarin Conjugates as Anti-Hepatitis C Virus Agents,” Antiviral Res. 2008, 77, 157–162. 2.Hwu, J. R.; Lin, Y. S.; Josephrajan, T.; Hsu, M.-H.; Cheng, F.-Y.; Yeh, C.-S.; Su, W.-C.; Shieh, D.-B. “Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles,” J. Am. Chem. Soc. 2009, 131, 66–68. 3.Hwu, J. R.; Huang, J.-T.; Tsai, F.-Y., Tsay, S.-C.; Hsu, M. H.; Hwang, K. C.; Horng, J.-C.; Ho, J.-a. A. Lin C.-C. “Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides as well as Their Application to DNA Cleavage,” Cover Article; Chem.--Eur. J. 2009, 15, 8742–8750. 4.Tsai, T.-L.; Shieh, D.-B.; Yeh, C.-S.; Tzeng, Y.-H.; Hete, K.; Chuang, K.-S.; Hwu, J. R.; Su, W.-C. “The Down Regulation of Target Genes by Photo Activated DNA Nanoscissors,” Biomaterials 2010, 31, 6545–6554. 5.Hwu, J. R.; Lin, S.-Y.; Tsay, S.-C.; De Clercq, E.; Leyssen, P.; Neyts, J. “Coumarin–Purine Ribofuranoside Conjugates as New Agents Against Hepatitis C Virus,” J. Med. Chem. 2011, 54, 2114–2126. 6.Hwu, J. R.; Chang Hsu, Y. "Stereospecific Benzyne-Induced Olefination from -Amino Alcohols and Its Application to the Total Synthesis of (–)-1-Deoxy-D-fructose," Chem.--Eur. J. 2011, 17, 4727–4731. 7.Chang Hsu, Y.; Hwu, J. R. “Deoxygenative Olefination Reaction as the Key Step in the Syntheses of Deoxy and Iminosugars,” Chem.--Eur. J. 2012, 18, 7686–7690. 8.Hwu, J. R.; Swain, S. P. “Silicon-Induced Phenanthrene Formation from Benzynes and Allenylsilanes,” selected as Highlights in Current Synthetic Organic Chemistry by SYNFACTS, Thieme; Chem.--Eur. J. 2013, 19, 6556–6560. 9.Hwu, J. R.; Kapoor, M.; Li, R.-Y.; Lin, Y.-C.; Horng, J.-C.; Tsay, S.-C. “Synthesis of Nucleobase Functionalized Carbon Nanotubes and Their Hybridization with Single-stranded DNA,” Cover Article; Chem. -- Asian J. 2014, 9, 3408–3412.