Cernak, Timothy - University of Michigan - Department of Medicinal Chemistry

个人简介

Awards Merck Green Chemistry Award Merck Rahway Innovation Award Terry D. Wilson Lectureship, University of Idaho Ocean Nutrition Canada Prize Robert Zamboni Award

研究领域

The Cernak Lab studies the interface of chemical synthesis and computer science. The functional and biological properties of a small molecule are encoded within structure, so synthetic strategies that access diverse structures are paramount to the invention of novel functional molecules such as biological probes, materials or pharmaceuticals. We use algorithms, robotics and big data to invent new chemical reactions, synthetic routes to natural products, and small molecule probes to answer questions in basic biology. Our lab employs informatics in reaction discovery, total synthesis, cell imaging and medicinal chemistry studies. Researchers in the group learn high-throughput experimentation, basic coding, and modern synthetic techniques. By studying the relationship of chemical synthesis to functional properties, we pursue the opportunity to positively impact human health.

近期论文

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Mycah R. Uehling, Ryan P. King, Shane W. Krska, Tim Cernak*, Stephen L. Buchwald*. "Pharmaceutical Diversification via Palladium Oxidative Addition Complexes", Science, 2019, 363, 405—408. Nathan J. Gesmundo, Bérengère Sauvagnat, Patrick Curran, Matthew P. Richards, Christine L. Andrews, Peter J. Dandliker, Tim Cernak*. “Nanoscale Synthesis and Affinity Ranking”, Nature, 2018, 557, 228—232. Tim Cernak*, et al. “Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors”, The Journal of Medicinal Chemistry, 2017, 60(9), 3594—3605. Featured Article. Alexander Buitrago Santanilla, Erik L. Regalado, Tony Pereira, Kevin Bateman, Louis-Charles Campeau, Simon Berritt, Yong Liu, Michael Shevlin, Zhi-Cai Shi, Jonathan Schneeweis, Christopher J. Welch, Roy Helmy, Petr Vachal, Ian Davies, Tim Cernak* and Spencer Dreher*. “Nanomolar-Scale High-Throughput Chemistry for the Synthesis of Complex Molecules”, Science, 2015, 347(6217), 49—53. Heike Schönherr and Tim Cernak*. “Profound Methyl Effects in Drug Discovery and a Call for New C-H Methylation Reactions”, Angewandte Chemie International Edition in English, 2013, 52(47), 12256—12267.