夏江 - 香港中文大学

个人简介

2021-now Professor, Department of Chemistry, and School of Life Sciences (by courtesy), the Chinese University of Hong Kong, China 2015-2021 Associate Professor, the Chinese University of Hong Kong 2009-2014 Assistant Professor, the Chinese University of Hong Kong 2007-2008 Postdoc (Advisor: Linda Hsieh-Wilson) California Institute of Technology/Howard Hughes Medical Institute, USA 2002-2006 PhD. (Advisor: Prof. Chaitan Khosla) Stanford University, USA 1999-2002 M.Sc. (Advisor: Prof. Wenxia Tang) Nanjing University, China 1995-1999 B.Sc. Department for Intensive Instruction, Nanjing University, China

研究领域

In recent years, spectacular developments have been witnessed in bioorthogonal reactions of biomacromolecules and their far-reaching influence on biomedical research, ultimately recognized by the awarding of the 2022 Nobel Prize in Chemistry. Based on bioorthogonal reactions and the principle of proximity-induced reactivity, our lab is dedicated to developing site-selective protein reactions – reactions that are precise to a single amino acid residue rather than one type of amino acid [1, 2]. Most recent discoveries include precise acetylation of Lys 248 of commercially available antibodies and precise functionalization of Tyr 296 of antibodies [3, 4]. The reactions yielded new strategies in immunotherapy. The second project in our lab is to develop phase-separating small molecules for intracellular delivery of proteins or nucleic acids. We have designed molecules that form phase-separated droplets and disintegrate upon photolysis, yielding a transfection agent that delivers protein into the cytoplasm [5, 6]. In the third project, we chemically or genetically modified the surface of exosomes to give outstanding targeting vehicles for drug delivery into the otherwise impenetrable cartilage and bring new treatments to osteoarthritis and osteoporosis [7-12]. The fourth project includes the development of biomaterials based on recombinant collagen for tissue engineering. Taken together, these projects underscore the use of chemical biology and synthetic biology principles in biomedicine.

近期论文

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Yang, L.; Choi, C. H. J.*; Wang, J.*; Xia, J.*; Zhang, L.*; Ngai, T.* Zi, Y.* Huang Z.* Celebrating 60 Years of The Chinese University of Hong Kong: Research Highlights in Nanoscience and Nanotechnology ACS Nano 2023, 10.1021/acsnano.3c11732 Huang, J.; Huang, Z.; Xiong, J.; Xia, J.; Wang, Y.; Yang, L.; Liang, Y.3D bioprinted scaffolds of polysaccharide hydrogels in osteochondral and cartilage tissue engineering Des. Monomers and Polym. 2023, 26, 258-272. Pan, X.; Ye, F.; Ning, P.; Zhang, Z.; Li, X.; Zhang, B.; Wang, Q.; Chen, G.; Gao, W.; Qiu, C.; Wu, Z.; Li, J.; Zhu, L.; Xia, J.*; Gong, K.; Du, Y.* Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2 Cell Discov. 2023, 9, 118. Liu, M.†; Wu, C. †; Wang, R.; Qiu, J.; She, Z.; Qu, J.; Xia, J.* Modulating Liquid-Liquid Phase Separation of Nck Adaptor Protein against Enteropathogenic Escherichia coli Infection ACS Cent. Sci. 2023 in press Chen, H.; Wong, H.-C. F.; Qiu, J.; Li, B.; Yuan, D.; Kong, H.; Bao, Y.; Zhang, Y.; Xu, Z.; Tse, Y.-L. S.*; Xia, J.* Site-Selective Tyrosine Reaction for Antibody-Cell Conjugation and Targeted Immunotherapy Adv. Sci. 2023, 10.1002/advs.202305012 Iqbal, Z.; Xia, J.; Murtaza, G.; Shabbir, M.; Rehman, K.; Liang, Y.; Duan, L. Targeting WNT Signalling Pathways as New Therapeutic Strategies for Osteoarthritis Journal of Drug Targeting 2023, 31, 1027-1049. Xu, X.; Iqbal, Z.; Xu, L.; Wen, C.; Duan, L.; Xia, J.; Yang, N.; Zhang, Y.; Liang, Y. Brain‐derived Extracellular Vesicles: Potential Diagnostic Biomarkers for Central Nervous System Diseases Psychiatry Clin. Neurosci. 2023 Zhang, Z.; Zhao, S.; Sun, Z.; Zhai, C.; Xia, J.; Wen, C.; Zhang, Y.; Zhang, Y. Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis Cell. Mol. Biol. Lett. 2023, 28 (1), 75 Xiao, Q.; Li, Z.; Miao, Y.; Xia, J.; Wu, M. Editorial: Prodrug design and therapeutic applications Frontiers in Pharmacology 2023, 14, 1280190 Wang, R.; Bao, Y.; Xia, J.* Exploring the Binding Interaction between Phosphotyrosine Peptides and SH2 domains by Proximal Crosslinking SH2 Domains: Functional Modules and Evolving Tools in Biology, Springer US, 255-267. Bao, Y.+; Chen, H.+; Xu, Z.; Gao, J.; Jiang, L.; Xia, J.* Photo-Responsive Phase-Separating Fluorescent Molecules for Intracellular Protein Delivery Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202307045 Xu, X.; Xu, L.; Wen, C.; Xia, J.; Zhang, Y.; Liang, Y. Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform Materials Today Bio 2023, doi: 10.1016/j.mtbio.2023.100760 Xu, X.; Xu, L.; Xia, J.; Wen, C.; Liang, Y.; Zhang, Y. Harnessing Knee Joint Resident Mesenchymal Stem Cells in Cartilage Tissue Engineering Acta Biomater. 2023, 168, 372-387. Xu, L.†; Xu, X.†; Liang, Y.; Wen, C.; Ouyang, K.; Huang, J.; Xiao, Y.; Deng, X.; Xia, J.*; Duan, L.* Osteoclast-Targeted Delivery of Anti-miRNA Oligonucleotides by Red Blood Cell Extracellular Vesicles. Journal of Controlled Release 2023, 358, 259-272. Iqbal, Z.; Rehman, K.; Xia, J.; Shabbir, M.; Zaman, M.; Liang, Y.; Duan, L. Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for Precise Gene Editing. Biomater. Sci., 2023, 11, 3762-3783. Wang, B.; Zhao, D.; Li, Y.; Zhou, X.; Hui, Z.; Lei, X.; Qiu, L.; Bai, Y.; Wang, C.; Xia, J.; Xuan, Y.; Jiang, P.; Wang, J. Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds. ACS Applied Nano Materials 2023, 6, 6891-6900. Wang, X.; Zhao, D.; Li, Y.; Zhou, X.; Hui, Z.; Lei, X.; Qiu, L.; Bai, Y.; Wang, C.; Xia, J.; Xuan, Y.; Jiang, P.; Wang, J. Collagen Hydrogel with Multiple Antimicrobial Mechanisms as Anti-Bacterial Wound Dressing. International Journal of Biological Macromolecules 2023, 232, 123413. Liu, M.; Wang, Y.; Jiang, H.; Han, Y.; Xia, J.* Synthetic Multienzyme Assemblies for Natural Product Biosynthesis. ChemBioChem, 2023, 24, e202200518. Huang, J.; Liu, Q.; Xia, J.; Chen, X.; Xiong, J.; Yang, L.; Liang, Y. Modification of mesenchymal stem cells for cartilage-targeted therapy. Journal of Translational Medicine 2022, 20 (1), 515. Tuan, R. S., Zhang, Y. Z.; Chen, L.; Guo, Q.; Yung, P. S. H.; Jiang, Q.; Lai, Y.; Yu, J.; Luo, J.; Xia, J.; Xu, X.; Lei, G.; Su, J.; Luo, X.; Zou, W.; Qu, J.; Song, B.; Zhao, X.; Ouyang, H.; Li, G.; Ding, C.; Wan, C.; Chan, B. P.; Yang, L.; Xiao, G.; Shi, D.; Xu, J.; Cheung, L. W. H.; Bai, X.; Xie, H.; Xu, R.; Li, Z. A.; Chen, D.; Qin, L. Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration. Journal of Orthopaedic Translation 2022, 37, 175. Liu, Q.; Huang, J.; Xia, J.; Liang, Y.; Li, G. Tracking tools of extracellular vesicles for biomedical research. Frontiers in Bioengineering and Biotechnology 2022, 10.3389/fbioe.2022.943712 Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.*; Xia, J.* Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering. Molecular Therapy 2022 Accepted. (Review) Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.*; Xia, J.* Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J. Am. Chem. Soc. Accepted. Wang, C.; Li, Y.; Liu, L.; Liu, M.; Chen, X.; Zhou, S.; Cui, P.; Du, X.; Qiu, L.; Wang, J.*; Jiang, P.*; Xia, J.* Antimicrobial Nanozyme-Enzyme Complex Catalyzing Cascade Reaction of Glucose to Hydroxyl Radical to Combat Bacterial Infection Journal of Drug Delivery Science and Technology, 2022, accepted. Liang, Y.; Igbal, Z.; Wang, J.; Xu, L.; Xu, X.; Ouyang, K.; Zhang, H.; Lu, J.; Duan, L.; Xia, J.* Cell-Derived Extracellular Vesicles for CRISPR/Cas9 Delivery: Engineering Strategies for Cargo Packaging and Loading Biomaterials Science, 2022, 10, 4095 – 4106. Shinge, S. A. U.; Xiao, Y.; Xia, J.; Liang, Y.; Duan, L. New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery Extracellular Vesicles and Circulating Nucleic Acids 2022, 3, 150-162. Wei, Q.; Wang, Y.; Liu, Z.; Liu, M.; Cao, S.; Jiang, H.; Xia, J.* Multienzyme Assembly on Caveolar Membranes In Cellulo ACS Catalysis 2022, 12, 8372-8379. Lei, X.; Li, M.; Wang, C.; Cui, P.; Qiu, L.; Zhou, S.; Jiang, P.; Li, H.; Zhao, D.; Ni, X.; Wang, J.; Xia, J.* Degradable Microneedle Patches Loaded with Antibacterial Gelatin Nanoparticles to Treat Staphylococcal Infection-Induced Chronic Wounds International Journal of Biological Macromolecules, 2022, 217, 55-65. Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.* Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment Theranostics, 2022, 12, 4866-4878. Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.* Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote Angew. Chem. Int. Ed. 2022, e202203909. Huang, J.; Liu, F.; Su, H.; Xiong, J.; Yang, L.; Xia, J.; Liang, Y.* Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering Gels 2022, 8, 138. Huang, J.; Lei, L.; Huang, Z.; Rong, Z.; Li, H.; Xie, Y.; Duan, L.; Xiong, J.; Wang, D.; Zhu, S.; Liang, Y.*; Wang, J.*; Xia, J.* Gelatin – Recombinant Type III Collagen Hydrogel to Promote Wound Healing Int. J. Bioprinting 2022, 8, 517. Wang, X.; Qiu, L.; Wang, C.; Gao, Z.; Zhou, S.; Cui, P.; Jiang, P.; Hu, H.; Ni, X.*; Du, X.; Wang, J.*; Xia, J.* “Nanodot–doped peptide hydrogel for antibacterial phototherapy and wound healing” Biomater. Sci accepted Xu, L.; Liang, Y.; Xu, X.; Xia, J.; Wen, C.; Zhang, P.; Duan, L.* “Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems” Bioengineered 2021, doi.org/10.1080/21655979.2021.1982320. Huang, J.; Zhang, J.; Xiong, J.; Sun, S.; Xia, J.*; Yang, L.*; Liang, Y.* “Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing” Stem Cells International 2021, doi.org/10.1155/2021/1285087. So, W. H#.; Bao, Y.#; Chen, X.; Xia, J.* “On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides” Org. Lett. 2021, 23, 8277–8281. （# equal contribution) Bao, Y.; Qiu, J.; Xia, J.* “Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction” Methods in Molecular Biology 2021 in press. Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.*; Xia, J.* “Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing” ChemBioChem 2021, doi.org/10.1002/cbic.202100359. Chen, X.; Liu, M.; Zhang, P.; Xu, M.; Yuan, W.; Bian, L.; Liu, Y. Xia, J.*; Leung, S. S. Y.* “Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii” ACS Infectious Diseases, revised. Wang, R.; Liu, M.; Wang, H.; Xia, J.; Li, H.* “GB Tags: Small Covalent Peptide Tags Based on Protein Fragment Reconstitution” Bioconjugate Chem. 2021, 32, 1926-1934. Ho, M. K. Y.; Zhang, P.; Chen, X.; Xia, J.*; Leung, S. S. Y.* “Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies” Critical Reviews in Microbiology, 2021, 1-24. Liu, L.; Wang, C.; Li, Y.; Qiu, L.; Zhou, S.; Cui, P.; Jiang, P.; Ni, X.; Liu, R.; Du, X.; Wang, J.*; Xia, J.* “Manganese Dioxide Nanozyme for Reactive Oxygen Therapy of Bacterial Infection and Wound Healing” Biomater. Sci. 2021, 9, 5965 – 5976. Feng, L.; Wang, P.; Feng, Y.; Zhang, J.; Chen, Q.; Xie, Y.; Luo, J.; Xia, J.; Yao, S.; Sun, H. “A reversible microarray immobilization strategy based on thiol-quinone reaction” Chin. Chem. Lett. 2021 doi.org/10.1016/j.cclet.2021.06.056 Zhang, W.; Wu, Y.; Liu, L.; Xiao, X.; Cong, Z.; Shao, N.; Qiao, Z.; Chen, K.; Liu, S.; Zhang, H.; Ji, Z.; Shao, X.; Dai, Y.; He, H.; Xia, J.; Fei, J.; Liu, R. “Membrane-Targeting Mechanism of Host Defense Peptides Inspiring the Design of Polypeptide-Conjugated Gold Nanoparticles Exhibiting Effective Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus” J. Mater. Chem. B 2021, 5092-5101. Wei, Q.; Xia, J.* “Self-assembled Multienzyme Nanostructures for Biocatalysis in Cellulo” Methods in Molecular Biology 2021, in press. (Book chapter) Liu, M.; Chen, X.; Xia, J.* “Multienzyme Catalysis in Phase-Separated Protein Condensates” Methods in Molecular Biology 2021, in press. (Book chapter) Chen, X.; Liu, M.; Zhang, P.; Leung, S. S. Y.*; Xia, J.* “Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumannii” ACS Infect. Dis. 2021, 7, 2192–2204. Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* “Antimicrobial peptides towards clinical application: delivery and formulation” Adv. Drug Deliv. Rev. 2021, 175, 113818. Li, Q.; Zeng, C.; Liu, H.; Yung, K. W. Y.; Chen, C.; Xie, Q.; Zhang, Y.; Wah, S. W. C.; Mak, B. S. W.; Xia, J.; Xiong, S.; Ngo, J. C. K. “Novel protein–protein interaction inhibitor of SRPKs alters the splicing isoforms of VEGF and inhibits angiogenesis” iScience 2021, 24, 102423. Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic gold nanoparticles for skin infection” ACS Appl. Bio Mater. 2021, 4, 3124–3132. Qiu, L.; Wang, C.; Lei, X.; Du, X.; Guo, Q.; Zhou, S.; Cui, P.; Hong, T.; Jiang, P.; Wang, J.*; Li, Y.*; Xia, J.* “Gelatinase-responsive release of antibacterial photodynamic peptide against Staphylococcus aureus” Biomater. Sci. 2021, 9, 3433-3444. Huang, J.; Huang, Z.; Liang, Y.; Yuan, W.; Bian, L.; Duan, L.; Rong, Z.; Xiong, J.*; Wang, D.*; Xia, J.* “3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair” Biomater. Sci. 2021, 9, 2620. Liang Yujie, Xia, J.* “Non-surgical osteoarthritis therapy, intra-articular drug delivery toward clinical applications” J. Drug Targeting 2021, 1-16. Liang, Y.; Duan, L.; Lu, J.; Xia, J.* “Engineering exosomes for targeted drug delivery” Theranostics 2021, 11, 3183-3195. Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated delivery of gene vectors for gene therapy” Nanoscale 2021, 13, 1387 – 1397. (Featured on back cover). Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis” Curr. Med. Chem. 2021, 28, 6458-6483. Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Biomaterials 2021, 269, 120539. Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic peptides for staphylococcal skin infection” Biomater. Sci. 2020, 8, 6695-6702. Wei, Q.; He, S.; Qu, J.; Xia, J.* “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo” Bioconjug. Chem. 2020, 31, 2413–2420. Xiao, X.; Zhang, S.; Chen, S.; Qian, Y.; Xie, J.; Cong, Z.; Zhang, D.; Zou, J.; Zhang, W.; Ji, Z.; Cui, R.; Qiao, Z.; Jiang, W.; Dai, Y.; Wang, Y.; Shao, X.; Sun, Y.; Xia, J.; Fei, J.; Liu, R. “An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance” Biomater. Sci. 2020, 8, 6883-6889. Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria” Int. J. Pharmaceutics 2020, 589, 119833 Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* “Mesenchymal Stem Cell − Derived Exosomes for Treatment of Autism Spectrum Disorder” ACS Appl. Bio Mater. 2020,3, 6384−6393. Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy” ACS Appl. Mater. Interfaces 2020, 12, 36938–36947. Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”Anal. Chem. 2020, 92, 9322–9329. Zhao, P.; Yin, C.; Zhang, Y.; Chen, X.; Yang, B.; Xia, J.; Bian, L. “Mussel Cuticle-Mimetic Ultra-Tough, Self-Healing Elastomers with Double-Locked Nanodomains Exhibit Fast Stimuli-Responsive Shape Transformation” J. Mater. Chem. A 2020, 8, 12463-12471. Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* “Phase-separated multienzyme biosynthesis” Biomacromolecules 2020, 21, 2391-2399. Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism” Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. Lai, S. N.; Zhou, X.; Ouyang, X.; Zhou, H.; Liang, Y.; Xia, J.; Zheng, B. “Artificial Cells Capable of Long-Lived Protein Synthesis by Using Aptamer Grafted Polymer Hydrogel” ACS Synth. Biol. 2020, 9, 76–83.