Zhou, Yubin - Texas A&M University - Department of Industrial and Systems Engineering

个人简介

Education Bachelor of Medicine (M.D. Equivalent), Zhejiang University School of Medicine, 2003 M.S. Chemistry, Georgia State University, 2007 Ph.D. Biochemistry, Georgia State University, 2008 Clinical/Postdoctoral Training Clinical Internship, the Second Affiliated Hospital, Zhejiang University, 2000-2003 Research Fellow, Immune Disease Institute, Harvard Medical School 2008-2010 Instructor, La Jolla Institute for Allergy and Immunology, 2010-2012

研究领域

The Zhou Lab is exploring the frontiers of calcium signaling, optogenetics, immunoengineering and molecular therapy research by combining biophysics, immunology, chemical biology, drug screening, computational biology and mouse genetics. We are focused on elucidating the role of calcium channels and DNA modifications in health and diseases and designing better treatment and prevention strategies for cardiovascular disorders, autoimmune diseases and cancer. Ongoing research activities include: i) discovering novel ion channels that govern intracellular calcium homeostasis and T cell activities; ii) devising innovative optical actuators for remote control of cell signaling, (epi)genome editing and immunomodulation; and iii) designing better treatment and prevention strategies for immunoinflammatory diseases and tumors.

近期论文

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He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Siwko S, Huang Y, Wang Y, and Zhou Y. Engineering of a bona fide light-operated calcium channel. Nature Communications. 2020 (accepted) Wang T, He L, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y. Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style. Advanced Science. (IF: 16) 2020,2002148. (accepted) *Featured as a Cover article. Ma G, He L, Liu S, Xie J, Huang Z, Jing J, Lee, YT, Wang R, Luo H, Han W, Huang Y and Zhou Y. Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications. 2020,11(1):1039. (PMID: 32098964) *Highlighted in Commentary by Cell Calcium: “Natural photoswitches exposes STIM1 activation steps” Yang X, Ma G, Zheng S, Qin X, Li X, Du L, Wang Y, Zhou Y#, and Li M#. Optical control of CRAC channel using photoswitchable azopyrazoles. Journal of the American Chemical Society. 2020,142(20):9460-9470. (PMID: 32330031) *Featured by JACS as a Cover article. Li, J, Zhao S, Lee M, Yin Y, Li J, Zhou Y, Ballester LY, Esquenazi Y, Dashwood RH, Davies PJA, Parsons DW, Li XN, Huang Y, and Sun D. Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma Science Advances. 2020,6(42):eabb5427. (PMID: 33067228) *Highlighted in “Vital Record”. Zhang Z, Jing J, Ye Y, Chen Z, Jing Y, Li S, Hong W, Ruan H, Liu Y, Hu Q, Huang Y, Li W, Lin C, Diao L, Zhou Y#, and Han L#. Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors. Genome Medicine. 2020 (accepted) Guo L, Li J, Zeng H, Guzman A, Li T, Lee M, Zhou Y, Stefan C, Goodell MA, Stephan C, Davies PJA, Dawson M, Sun D, and Huang Y.A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi resistant leukemia cells. Nature Communications. 2020,11(1):740. (PMID: 32029739) Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Mo W, Xu R, Wang F, Chang J, Zhou Y, Sun D, Martin JF, and Huang Y. Tet inactivation disrupts YY1 binding and long-range chromatin interactions to cause developmental defects in embryonic heart. Nature Communications. 2019,10(1):4297. (PMID: 31541101) Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang HY, and Wang RF. Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development. The Journal of Clinical Investigation. 2019,129(12):5261-77. (PMID: 31503548). Tang J, Robichaux M, Wu KL, Pei J, Nguyen NT, Zhou Y, Wensel TG, and Xiao H. Single-atom fluorescence switch: a general approach towards visible light-activated dyes for biological imaging. Journal of the American Chemical Society. 2019,141(37):14699-706. (PMID: 31450884) Liu Z, Li H, He L, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y. Discovery of small molecule inhibitors of the HSP90-Calcineurin-NFAT pathway against glioblastoma. Cell Chemical Biology. 2019,26(3):352-65. (PMID: 30639261) *Highlighted as Cover Story; Featured in Vital Record and The Battalion. Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz R, Zhou Y, Zhao M, Chow R, Chuong CM. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications. 2018, 9(1):5377. (PMID: 30560870) Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, and Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLOS Biology. 2018,16(11):e3000051. (PMID: 30408026) *Highlighted as Editor’s Picks in cancer cell signaling; Featured in “Vital Record”. Zheng S, Ma G, He L, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko RM, Gill DL, Dong H, Zhou Y#, and Wang Y#. Identification of molecular determinants that govern distinct STIM2 activation dynamics. PLOS Biology. 2018,16(11):e2006898. (PMID: 30444880; #: senior authors) Sang L, Hu H, Liu G, Tian T, Ma G, Lu Y, Liu Z, Pan R, Li R, Piao H, Marks JR, Yang L, Yan Q, Wang W, Shao J, Zhou Y, Zhou T, and Liu A. LncRNA CamK-A regulates Ca2+-signaling-mediated tumor microenvironment remodeling. Molecular Cell. 2018,71(1):71-83. (PMID: 30220516) Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Dong WG, Zhou Y#, Wei-Guo Dong#, and Huang Y#. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2018 (PMID: 30390073; #: senior authors) Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komvies EA, Hogan PG. Calcium sensing by the STIM1 ER-luminal domain. Nature Communications. 2018,9(1):4536. (PMID: 30382093) Ma G, Zhang Q, He L, Nguyen NT, Liu S, Gong Z, Huang Y and Zhou Y. Genetically encoded tags for real time dissection of protein assembly in living cells. Chemical Science. 2018, 9(25):5551-9. (PMID:30061986). *Highlighted in theme collection of 2018 Chemical Science Hot Articles and Chem Sci Pick of the week by Royal Society of Chemistry. Feature by Clinical Lab Products, Front Line Genomics, and Futurity. Ma G, Liu J, Ke Y, Liu X, Li M, Wang F, Han G, Huang Y, Wang Y and Zhou Y. Optogenetic control of voltage gated calcium channels. Angewandte Chemie. 2018 (PMID: 29569306). *Highlighted as Cover story; Feature by BioOptics World and Photonics Media. Nguyen NT, He L, Martinze-Moczygemba M, Huang Y and Zhou Y. Rewiring calcium signaling for precise transcriptional reprogramming. ACS Synthetic Biology. 2018,7(3):814-21. (PMID: 29489336). *Feature by The Battalion; Photonics Media; BioOptics World and Futurity.