Voss, John - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

My research interests are in observing molecular switching in proteins, as well as protein folding and assembly. This work is carried out in large part through the use electron paramagnetic resonance (EPR — a.k.a. ESR) spectroscopy of site-directed spin labels. We use this approach to address problems in several biological systems, including those related to cardiovascular and neurodegenerative diseases.

近期论文

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Ly S, Altman R, Petrlova J, Lin Y, Hilt S, Huser T, Laurence TA, and Voss JC. Binding of apolipoprotein E inhibits the oligomer growth of amyloid beta in solution as determined by fluorescence cross correlation spectroscopy. J Biol Chem. 2013; in press. Acar S, Carlson DB, Budamagunta MS, Yarov-Yarovoy V, Correia JJ, Niñonuevo MR, Jia W, Tao L, Leary JA, Voss JC, Evans JE, Scholey JM., The bipolar assembly domain of the mitotic motor kinesin-5, Nat Commun. 2013 Jan 8;4:1343. doi: 10.1038/ncomms2348. den Hartigh LJ, Altman R, Hutchinson R, Petrlova J, Budamagunta MS, Tetali SD, Lagerstedt JO, Voss JC, Rutledge JC., Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation., PLoS One. 2012;7(11):e50513. doi: 10.1371/journal.pone.0050513. Epub 2012 Nov 28. Hess JF, Budamagunta MS, Aziz A, FitzGerald PG, Voss JC., Electron paramagnetic resonance analysis of the vimentin tail domain reveals points of order in a largely disordered region and conformational adaptation upon filament assembly., Protein Sci. 2013 Jan;22(1):47-55. doi: 10.1002/pro.2182. Li Y, Budamagunta MS, Luo J, Xiao W, Voss JC, Lam KS., Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins., ACS Nano. 2012 Nov 27;6(11):9485-95. doi: 10.1021/nn302317j. Epub 2012 Oct 30. Aziz A, Hess JF, Budamagunta MS, Voss JC, Kuzin AP, Huang YJ, Xiao R, Montelione GT, FitzGerald PG, Hunt JF., The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography., J Biol Chem. 2012 Aug 17;287(34):28349-61. doi: 10.1074/jbc.M111.334011. Epub 2012 Jun 26. Petrlova J, Kálai T, Maezawa I, Altman R, Harishchandra G, Hong HS, Bricarello DA, Parikh AN, Lorigan GA, Jin LW, Hideg K, Voss JC., The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide., PLoS One. 2012;7(4):e35443. doi: 10.1371/journal.pone.0035443. Epub 2012 Apr 30. Lagerstedt JO, Budamagunta MS, Liu GS, DeValle NC, Voss JC, Oda MN., The "beta-clasp" model of apolipoprotein A-I--a lipid-free solution structure determined by electron paramagnetic resonance spectroscopy., Biochim Biophys Acta. 2012 Mar;1821(3):448-55. doi: 10.1016/j.bbalip.2011.12.010. Epub 2012 Jan 8. Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW., Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons., J Biol Chem. 2012 Feb 17;287(8):5253-66. doi: 10.1074/jbc.M111.276162. Epub 2011 Dec 12. Ly S, Petrlova J, Huser T, Fore S, Gao T, Voss J, Laurence TA., Stoichiometry of Reconst High-Density Lipoproteins in the Hydrated State Determined by Photon Antibunching., Biophys J, 2011; 101: 970-975. Kálai T, Petrlova J, Balog M, Aung HH, Voss JC, Hideg K., Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds., Eur J Med Chem. 2011 Apr;46(4):1348-55. doi: 10.1016/j.ejmech.2011.01.059. Epub 2011 Feb 3. Petrlova J, Hong HS, Bricarello DA, Harishchandra G, Lorigan GA, Jin LW, Voss JC., A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution., Proteins. 2011 Feb;79(2):402-16. doi: 10.1002/prot.22891. Lagerstedt JO, Cavigiolio G, Budamagunta MS, Pagani I, Voss JC, Oda MN., Structure of apolipoprotein A-I N terminus on nascent high density lipoproteins., J Biol Chem. 2011 Jan 28;286(4):2966-75. doi: 10.1074/jbc.M110.163097. Epub 2010 Nov 3. Nygaard EB, Lagerstedt JO, Bjerre G, Shi B, Budamagunta M, Poulsen KA, Meinild S, Rigor RR, Voss JC, Cala PM, Pedersen SF., Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1., J Biol Chem. 2011 Jan 7;286(1):634-48. doi: 10.1074/jbc.M110.159202. Epub 2010 Oct 25. Tetali SD, Budamagunta MS, Simion C, den Hartigh LJ, Kálai T, Hideg K, Hatters DM, Weisgraber KH, Voss JC, Rutledge JC., VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation., J Lipid Res. 2010 Jun;51(6):1273-83. doi: 10.1194/jlr.M000406. Epub 2009 Dec 3. Hatters DM, Voss JC, Budamagunta MS, Newhouse YN, Weisgraber KH., Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy., J Mol Biol. 2009 Feb 13;386(1):261-71. doi: 10.1016/j.jmb.2008.12.040. Epub 2008 Dec 24.