Sweeney, Colleen - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

Receptor tyrosine kinases in breast tumor progression and therapeutic resistance Tumor suppressors & oncogenes in breast cancer Mouse models of breast cancer

近期论文

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Hatakeyma, J., Wald, J.H, Rafidi, H., Cuevas, A., Sweeney, C. and Carraway, K.L. III. The ER structural protein Rtn4a stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3. 2016 Science Signaling, Jun 28;9(434):ra65. *Cover of journal* Rungrojsakul, M., Katekunlaphan, T., Saiai, A., Ampasavate, C., Okonogi, S, Sweeney, C. and Anuchapreeda, S. Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. 2016. BMC Complementary and Alternative Medicine, May 18;16(1):130. Rowson-Hodel, A.R., Berg, A.L., Wald, J.H, Hatakeyama, J., VanderVorst, K., Curiel, D.A., Leon, L.J., Sweeney, C. and Carraway, K.L. III. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. 2016 Cancer Letters, May 28;375(1):62-72. Amir, S., Simion, C., Umeh, M., Krig, S., Moss, T., Carraway, K.L. III and Sweeney, C. Regulation of the T-box transcription factor TBX3 by the tumor suppressor microRNA-206 in breast cancer. 2016 British Journal of Cancer, May 10;114(10):1125-34. Yokdang, N., Hatakeyama, J., Wald, J.H., Simion, C., Tellez, J.D., Chang, D.Z., Swamynathan, M.M., Chen, M., Murphy. W.J., Carraway, K.L. III and Sweeney, C. LRIG1 opposes epithelial to mesenchymal transition and inhibits invasion of basal-like breast cancer cells. 2016 Oncogene, Jun 2;35(22):2932-47. Morrison, M.M., Williams, M.M., Vaught, D.B., Hicks, D., Lim, J., McKernan, C., Aurisicchio, L., Cennaro, G., Simion, C., Sweeney, C. and Cook, R.S. Decreased Lrig1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 up-regulation and increased growth. 2016 Oncogene, Mar 3;35(9):1206. Bekki, K., Vogel, H., Li, W., Ito, T., Sweeney, C., Haarmann-Stemman, T., Matsumura, F., Vogel, C. The Aryl Hydrocarbon receptor (AhR) mediates resistance to apoptosis in breast cancer cells. 2015 Pesticide Biochemistry and Physiology, 2015 May;120:5-13. Candas, D., Lu, C.L., Fan, M., Chuang, F.Y.S., Sweeney, C., Borowsky, A.D., and Li, J.J. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. 2014 Cancer Research, Dec 15;74(24):7498-509. *Top Story, Mammary Cell News, Nov. 13th 2014.* Simion, C. Prieto, M. Sweeney, C. “The LRIG family – enigmatic regulators of growth factor receptor signaling”, 2014 Endocrine Related Cancer, Dec; 21(6):R431-R443. *Invited peer-reviewed review* Frietze, S., Geen, H., Simion, C., Littlepage, L.E., Sweeney, C., Farnham, P.J. and Krig, S.R. Analysis of ZNF217 chromatin occupancy reveals an association with ER-positive breast cancer. 2014 BMC Genomics, Jun 24;15:520. Printsev, I. Yen, L, Sweeney, C. and Carraway, K.L. III. Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination. 2014 J.Biol.Chem March 21; 289(12):8570-8. Rafidi, H.R., Mercado, F.M., Astudillo, M., Fry, W.H., Carraway, K.L. III and Sweeney, C. Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action towards ErbB receptor tyrosine kinases is opposed by Leucine-rich repeat and immunoglobulin domain-containing protein-3 (Lrig3). 2013 J. Biol. Chem. July 26, 288(30): 21593-605. Littlepage, L.E., Adler, A.S., Kouros-Mehr, H., Huang, G., Chou, J., Krig, S.R., Griffith, O.L., Korkola, J.E., Qu, K., Lawson, D.A., Xue, Q., Sternlicht, M.D., Dijkgraaf, G.J.P., Yaswen, P., Rugo, H.S., Sweeney, C., Collins, C.C., Gray, J.W., Chang, H.Y., Werb, Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. 2012 Cancer Discovery, Jul;2(7):638-51. Krig, S.R., Frietze, S., Simion, C, Miller, J.K., Fry, W.H., Rafidi, H., Kotelawala, L., Qi, L., Griffith, O., Gray, J.W., Carraway, K.L. III and Sweeney C. Lrig1 is an estrogen regulated growth suppressor and correlates with longer relapse-free survival in ERa-positive breast cancer. 2011 Molecular Cancer Research, 9(10):1406-17. *Highlighted by Connexon Creative Mammary Cell News, August 11 2011* Vogel, C., Li, W., Wu, D., Miller, J.K., Sweeney, C., Lazennec, G., Fujisawa, Y., and Matsumura, F. Interaction of Aryl hydrocarbon receptor and NF-B subunit RelB in breast cancer is associated with Interleukin-8 overexpression. 2011 Archives of Biochemistry and Biophysics, 512(1):78-86. Fry WH, Simion C, Sweeney C., Carraway KL III. Quantity Control of the ErbB3 Receptor Tyrosine Kinase at the Endoplasmic Reticulum. 2011 Molecular and Cellular Biology, 31(14):3009-18. Semsri, S., Krig, S.R., Kotelawala, L., Sweeney, C.*, and Anuchapreeda, S*. Inhibitory mechanism of pure curcumin on Wilm’s tumor 1 (WT1) gene expression through the PKCa signaling pathway. 2011 Febs Letters, 585(14):2235-42. * co-Corresponding authors Krig, S.R., Miller, J.K., Frietze, S., Beckett, L.A., Neve, R., Farnham, P.J., Yaswen, P. and Sweeney, C. ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. 2010 Oncogene, Oct 7;29(40):5500-10. *Highlighted by Connexon Creative Mammary Cell News, July 29 2010* Ingalla, E.Q., Miller, J.K., Wald, J.H., Workman, H.C., Kaur, R.P, Yen, L., Fry, W.H., Borowsky, A.D., Young, L.J.T., Sweeney, C., and Carraway, K.L. III. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. 2010. J. Biol. Chem, Sep 10;285(37):28691-7. Silva, A., Fry, W.H.D., Sweeney, C. and Trainor, B.C. Effects of photoperiod and experience on aggressive behavior in female California mice. 2010 Behavioral Brain Research, 208(2):528-34.