Seldin, Michael F. - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

Our laboratory studies the genetics/genomics of the inheritance of complex human diseases and human population genetic substructure. Collectively, our studies ascertain and apply genotypes from hundreds of thousands of single nucleotide polymorphisms in sample sets of several thousand individuals in efforts to define various aspects of human variation that result in medically important traits. Analytic methods include the application of different algorithms to perform genome-wide association screens, define population groups, admixture mapping, conduct genetic epidemiology studies and suggest evidence for natural selection. Specific disease studies include ongoing efforts in systemic lupus erythematosus, primary biliary cirrhosis, myasthenia gravis, and rheumatoid arthritis as well as collaborative studies in the Women’s Health Initiative.

近期论文

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Tian C, Hinds DA, Shigeta R, Kittles R, Ballinger DG, and Seldin MF. A genomewide single-nucleotide–polymorphism panel with high ancestry information for African American admixture mapping. Am J Hum Genet, 2006. 79(4): 640-649. Seldin MF, Shigeta R, Villoslada P, Selmi C, Tuomilehto J, Silva G, Belmont JW, Klareskog L, Gregersen P. European population substructure: clustering of northern and southern populations. PloS Genetics, 2006. 2(9): 1339-1351(e143:1-13). Seldin MF, Tian C, Shigeta R, Scherbarth HR, Silva G, Belmont JW, Kittles R, Gamron S, Allevi A, Palatnik SA, Alvarellos A, Paira S, Caprarulo C, Guillerón C, Catoggio LJ, Prigione C, Berbotto GA, García MA, Perandones CE, Pons-Estel BA, Alarcon-Riquelme ME. Argentine population genetic structure: large variance in Amerindian contribution. Am J Phys Anthropol, 2006. 132(3): 455-462. Tian C, Hinds DA, Shigeta R, Adler SG, Lee A, Pahl MV, Silva G, Belmont JW, Hanson RL, Knowler WC, Gregersen PK, Ballinger DG, Seldin MF. A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet, 2007. 80(6): 1014-1023. Seldin MF. Admixture mapping as a tool in gene discovery. Current Opinions in Genetics and Development, 2007. 17(3): 177-181. Thorburn CM, Prokunina-Olsson L, Sterba KA, Lum RF, Seldin MF, Alarcon-Riquelme ME, Criswell LA. Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes and Immunity, 2007. 8(4): 279-287. Remmers EF, Plenge RM, Lee AT, Graham RP, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos, CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med, 2007. 357(10): 977-986. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies RL, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med, 2007. 357(12): 1199-1209.