Olson, David E. - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

We investigate how small molecules regulate learning and memory by employing a multi-disciplinary approach involving organic synthesis, molecular neurobiology, and behavioral neuropharmacology. The ability to acquire, store, and retrieve information is a critical function of the human brain. As a result, impaired cognition characterizes nearly every brain disorder from Alzheimer’s disease and addiction, to schizophrenia, autism, and post-traumatic stress disorder. Our research not only provides insight into the fundamental mechanisms of learning and memory, but also suggests novel therapeutic strategies for treating these debilitating neurodegenerative and neuropsychiatric disorders.

近期论文

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Zhu, J. S.; Larach, J. M.; Tombari, R. J.; Gingrich, P. W.; Bode, S. R.; Tuck, J. R.; Warren, H. T.; Son, J.-H.; Duim, W. C.; Fettinger, J. C.; Haddadin, M. J.; Tantillo, D. J.; Kurth, M. J.; Olson, D. E. "A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion." Org. Lett. 2019, ASAP. Tombari, R. J.; Saunders, C. M.; Wu, C.-Y.; Dunlap, L. E.; Tantillo, D. J.; Olson, D. E. "Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR." ACS Chem. Biol. 2019, ASAP. Cameron, L. P.; Benson, C. J.; DeFelice, B. C.; Fiehn, O.; Olson, D. E. "Chronic, Intermittent Microdoses of the Psychedelic N,N‐Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents." ACS Chem. Neurosci., 2019, 10, 3261−3270. Kearney, S. E.; et al. "Canvass: A Crowd-Sourced Natural-Product Screening Library for Exploring Biological Space." ACS Cent. Sci., 2018, 4, 1727–1741. Olson, D. E. "Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics" J. of Exp. Neurosci. 2018, 12, 1–4. https://doi.org/10.1177/1179069518800508. Cameron, L. P.; Olson, D. E. "Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT)" ACS Chem. Neurosci. 2018, ASAP. Dunlap, L. E.; Andrews, A. A.; Olson, D. E. "Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine" ACS Chem. Neurosci. 2018, ASAP. Ly, C.; Greb, A. C.; Cameron, L. P.; Wong, J. M.; Barragan, E. V.; Wilson, P. C.; Burbach, K. F.; Soltanzadeh Zarandi, S.; Sood, A.; Paddy, M. R.; Duim, W. C.; Dennis, M. Y.; McAllister, A. K.; Ori-McKenney, K. M.; Gray, J. A.; Olson, D. E. "Psychedelics Promote Structural and Functional Neural Plasticity" Cell Reports 2018, 23, 3170–3182. Su, J. Y.; Olson, D. E.; Ting, S. I.; Du Bois, J. "Synthetic Studies Toward Pactamycin Highlighting Oxidative C–H and Alkene Amination Technologies" J. Org. Chem. 2018, 83, 7121–7134. Cameron, L. P.; Benson, C. J.; Dunlap, L. E.; Olson, D. E. "Effects of N,N-dimethyltryptamine (DMT) on rat behaviors relevant to anxiety and depression" ACS Chem. Neurosci. 2018, 9, 1582–1590. Olson, D. E.; Sleiman, S. F.; Bourassa, M. W.; Wagner, F. F.; Gale, J. P.; Zhang, Y.-L.; Ratan, R. R.; Holson, E. B. “Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress by Forming Catalase Mimetic Complexes with Intracellular Iron” Cell Chem. Biol. (formerly Chem. Biol.) 2015, 22, 439-445. Sleiman, S. F.; Olson, D. E.; Bourassa, M. W.; Karuppagounder, S. S.; Zhang, Y.-L.; Gale, J.; Wagner, F. F.; Basso, M.; Coppola, G.; Pinto, J. T.; Holson, E. B.; Ratan, R. R. “Hydroxamic Acid-based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition” J. Neurosci. 2014, 34, 14328-14337. Olson, D. E.; Su, J. Y.; Roberts, D. A.; Du Bois, J. “Vicinal Diamination of Alkenes under Rh-Catalysis” J. Am. Chem. Soc. 2014, 136, 13506-13509.