Jue, Thomas - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

Dr. Jue applies nuclear magnetic resonance (NMR) spectroscopic/imaging techniques to study metabolic regulation in in vivo. His current research focuses on the metabolic regulation of muscle in terrestrial and marine mammals 2) the function of myoglobin (Mb) in the cell, especially with respect to fatty acid regulation 3) cellular architecture in regulating the diffusion and reactivity of biomolecules 4) sialic acid supplementation and cognitive improvement 5) the biochemical alterations in the pathogenesis of chronic traumatic encephalopathy 6) the biochemical mechanism underpinning the increased incidence of dementia with type 2 diabetes.

近期论文

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Takura, H., Ojino, M., Jue, T., Yamada, T., Furuchi, Y., Hashimoto, T., Iwase, S., and Masuda, K. Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion, Physiol. Reports, 5 (2), 1-10, 2017. e13112. doi: 10.14814/phy2.13112. Yamada, T., Takakura, H., Jue, T. Hashimoto, T. Ishizawa, R. Furuichi, Y. Kato, Y., Iwanaka, N. Masuda, K. Myoglobin and the regulation of mitochondrial respiratory chain complex IV. J. Physiol., 594, 483-495, 2016. doi: 10.1113/JP270824. Shih, L., Chung, Y., Sriram, R., and Jue, T. Interaction of myoglobin with oleic acid. Chem & Physics of Lipids, Chem Phys Lipids, 191, 115-122, 2015. doi: 10.1016/j.chemphyslip.2015.07.010. Park, J.M., Josan, S., Mayer, D., Hurd, R. E., Chung, Y., Bendahan, D., Spielman, D. M., and Jue, T., Hyperpolarized 13C NMR Observation of Lactate Kinetics in Skeletal Muscle, J Exp Biol, 18,3308-3318,2015. DOI: 10.1113/JP270824. Jue, T., Measuring Intracellular Oxygenation with the Myoglobin Signals, Encyclopedia of Magnetic Resonance, ed by John Griffiths and Paul Bottomley, John Wiley & Sons, 4, 635-642, 2015. DOI: 10.1002/9780470034590.emrstm1452. Takakura, H., Furuichi,Y.Yamada, T., Jue, T., Ojino, M., Hashimoto, T., Iwase, S., Hojo, T., Izawa, T., Masuda, K., Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle, Scientific Report, 5, 9403, 1-6, 2014. doi:10.1038/srep09403. Shih, L., Chung, Y., Sriram, R., and Jue, T., Palmitate Interaction with Physiological States of Myoglobin. Bioch BiophyActa, 1840, 656-666, 2014. DOI: 10.1016/j.bbagen.2013.10.028. Yamada, T. Yasuro, F., Hisashi, T., Hashimoto, T. Hanai, Y., Jue, T, and Masuda, K., Interaction between myoglobin and mitochondria in rat skeletal muscle, J. Appl. Physiol., 114(4):490-7, 2013. doi: 10.1152/japplphysiol.00789.2012. Sriram, R. Lagerstedt, J.O., Petrolova, J., Samardzic, H. Kreutzer, U., Xie, Hongtao, Kaysen, G. A., Desreux, J.F., Thonon, D. F., Jacques, V., Van Loan, M., Rutledge, J. C., Oda, M. N., Voss, J. C., and Jue, T. Imaging apolipoprotein AI in vivo. NMR in Biomedicine 24, 916-24, 2011. doi: 10.1002/nbm.1650. Gros, G., Wittenberg, BA, and Jue, T. Myoglobin’s old and new clothes: form molecular structure to function in living cells. J. Exp. Biol 213: 2713-2725, 2010. doi: 10.1242/jeb.043075. Tomita, A., Kreutzer, U., Adachi, S., Koshihara, SY, and Jue, T. „It’s Hollow“: the function of pores within myoglobin. J. Exp. Biol. 213: 2748-2754, 2010. doi: 10.1242/jeb.042994. Takakura, H., Masuda, K., Hashimoto, T., Iwase, S., and Jue, T. Quantificatiion of myoglobin deoxygenation and intracellular partial pressure of O2 during muscle contraction during haemoglobin-free medium perfusion, Exp. Physiol. 95, 630-640, 2010. doi: 10.1113/expphysiol.2009.050344. Xie, H., Kreutzer, U., and Jue, T. Oximetry with the NMR signals of hemoglobin Val E1 1 and Tyr C7. Eur J Appl Physiol. 107, 325-33, 2009. DOI 10.1007/s00421-009-1125-3. Sriram, R., Kreutzer, U., Shih, L., Jue, T. Interaction of fatty acid with myoglobin. FEBS Lett, 582(25-26): 3643-9, 2008. doi: 10.1016/j.febslet.2008.09.047. Ponganis, P. J., Kreutzer, U., Stockard, T. K., Lin, P. C., Sailasuta, N., Tran, T. K., Hurd, R., Jue, T. Blood flow and metabolic regulation in seal muscle during apnea. J Exp Biol, 211 (Pt 20): 3323-32, 2008. doi: 10.1242/jeb.018887. Lin, P. C., Kreutzer, U., Jue, T. Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture. Biophys J, 92(7): 2608-20, 2007. doi: 10.1529/biophysj.106.094458.