Deng, Wenbin - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

The Deng Lab is interested in studying neural development and disease. We investigate how stem cells differentiate and give rise to neurons and glia, and then the grey matter and white matter and connected regions, and how variations in basic programs of development underlie nervous system disorders. We use mouse and human model systems, genetic fate mapping strategies, cellular and behavioral phenotyping, and high throughput library or omics techniques. Current projects focus on the regulation of neural stem cell identity and differentiation using human induced pluripotent stem cells (hiPSC) differentiated into neurons and glia and their interconnected networks in vitro, genetic and epigenetic regulation of neural development and disease in hiPSC models or using mouse models, and stem cell responses to environmental perturbations, including hypoxia-ischemia, oxidative stress, and inflammation. We then use these models and technology platforms to identify therapeutic targets and intervention strategies.

近期论文

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Jiang P, Chen C, Liu X, Pleasure DE, Liu Y, Deng W. (2016) Human iPSC-derived immature astroglia promote oligodendrogenesis by increasing TIMP-1 secretion. Cell Reports, 15 (6): 1303-1315. doi: 10.1016/j.celrep.2016.04.011. PMID: 27134175. Daugherty DJ, Chechneva OV, Mayrhofer F, Deng W. (2016) The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci. Reports, 2016 Mar 1;6:22556. doi: 10.1038/srep22556. PMID: 26925573. http://www.nature.com/articles/srep22556. Zhang M, Biswas S, Deng W*, Yu H*. (2016) The crystal structure of monovalent streptavidin. Sci. Reports, 2016 Dec 1; 6:35915. DOI: 10.1038/srep35915. http://www.nature.com/articles/srep35915. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. (2016) Same-single-cell analysis of pacemaker-specific markers in human induced pluripotent stem cell-derived cardiomyocyte subtypes classified by electrophysiology. Stem Cells. 2016 Jul 19. doi: 10.1002/stem.2466. PMID: 27434649. Chechneva OV, Deng W. (2016) Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation. Neural Regen Res 11(7):1056-1057. PMID: 27630677. Jiang P, Deng W. (2016) Regenerating white matter using human iPSC-derived immature astroglia. Neurogenesis (Austin). 2016 Sep 8; 3(1):e1224453. doi: 10.1080/23262133.2016.1224453. eCollection 2016. PMID: 27652287. Tian Z, Guo F, Biswas S*, Deng W*. (2016) Rationale and methodology of reprogramming for generation of induced pluripotent stem cells and induced neural progenitor cells. Int. J. Mol. Sci. 17 (4), 594; doi:10.3390/ijms17040594. *Co-correspondence authors. Zhang M, Biswas S, Qin X, Gong W, Deng W*, Yu H*. (2016) Does Notch play a tumor suppressor role across diverse carcinomas? Cancer Med. 2016 Aug; 5(8): 2048-2060. doi: 10.1002/cam4.731. PMID: 27228302. *Co-correspondence authors. Liu X, Shen Y, Pleasure DE, Deng W. (2016) The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci, 17 (2), DOI 10.1186/s12868-015-0237-4. Zhai L, Wang L, Teng F, Zhou L, Zhang W, Xiao J, Liu Y, Deng W. (2016) Argonaute and argonaute-bound small RNAs in stem cells. Int. J. Mol. Sci. 17 (2): 208. doi: 10.3390/ijms17020208 Chen C, Chan A, Wen H, Chung SH,Deng W*, Jiang P*. (2015) Stem and progenitor cell-derived astroglia therapies for neurological diseases. Trends Mol Med, 21 (11): 715-729.*Co-correspondence authors. Li S, Xue H, Wu J, Rao MS, Kim D, Deng W, Liu Y. (2015) Human iPSC NEUROG2 dual reporter knockin lines generated by the CRISPR/Cas9 system. Stem Cells Dev, 24 (24): 2925-2942. doi:10.1089/scd.2015.0131. PMID: 26414932. Chung SH, Biswas S, Selvaraj V, Liu X-B, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W. (2015) The p38α mitogen activated protein kinase is a key regulator of myelination and remyelination in the CNS. Cell Death & Dis, (2015) 6, e1748. doi:10.1038/cddis.2015.119. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure DE. (2015) The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci, 35 (9):3756-3763. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. (2015) The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci, 35 (12): 5007-5022. Xiao J, Yang R, Yang L, Fan X, Liu W, Deng W. (2015) Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and Th17 cells and inducing apoptosis of effector T cells. Sci. Reports, 5, 9022; DOI:10.1038/srep09022 (2015). Chechneva OV, Deng W. (2015) Empowering sonic hedgehog to rescue brain cells after ischemic stroke.Neural Regen Res, 10 (3): 360-362. doi: 10.4103/1673-5374.153677. PMID: 25878576 [PubMed]. Qin X, Xu H, Gong W, Deng W. (2015) The tumor cytosol miRNAs, fluid miRNAs and exosome miRNAs in cancer. Front. Oncol. 4: 357. doi: 10.3389/fonc.2014.00357 (2015). PMID: 25601903 [PubMed]. Xiao J, Yang R, Biswas S, Qin X, Zhang M, Deng W. (2015) Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. Int. J. Mol. Sci. 16: 9283-9302; doi:10.3390/ijms16059283. Liu Y, Deng W. (2015) Reverse engineering human neurodegenerative disease using pluripotent stem cell technology. Brain Res 941. Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W. (2014) A smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death & Dis, (2014) 5, e1481. doi:10.1038/cddis.2014.446 (2014). Lo U, Selvaraj V, Plane JM, Chechneva OV, Otsu, K, Deng W. (2014) p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci. Reports, 4: 7405; DOI:10.1038/srep07405 (2014). Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. (2014) Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells. Nature Communications . 5:4430 doi: 10.1038/ncomms5430 (2014). Jiang P, Chen C, Wang R, Chechneva OV, Chung S, Rao M, Pleasure DE, Liu Y, Zhang Q, Deng W. (2013) hESC-derived Olig2+ progenitors generate a subtype of astrocytes with protective effects against ischemic brain injury. Nature Communications, 4: 2196 doi: 10.1038/ncomms3196 (2013). Daugherty DJ, Selvaraj S, Chechneva OV, Liu X, Pleasure DE, Deng W. (2013) A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med, 5 (6): 891-903.