Carraway, Kermit L. - University of California, Davis - Department of Biochemistry and Molecular Medicine

研究领域

The lab uses biochemical, cell biological, pharmacological and genetic methods to dissect the roles of growth factors, their receptors and modulator proteins in mammalian development and in tumor initiation and progression. We are particularly interested in mechanisms of receptor ubiquitination and degradation, and how these processes impact the receptor overexpression that drives the malignancy of breast and brain tumors.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., and Lai, C. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 1997. 387, 512-516. PMID 9168115 Ghiglione, C., Carraway, K.L. III, Amundadottir, L.T., Boswell, R.E., Perrimon, N. and Duffy, J.B. The transmembrane molecule Kekkon-1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell 1999. 96, 847-856. PMID 10102272 Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 2004. 24, 7748-7757. PMID 15314180 Yen, L., Cao, Z., Wu, X., Ingalla, E. R., Baron, C., Young, L. J., Gregg, J. P., Cardiff, R. D., Borowsky, A. D., Sweeney, C., and Carraway, K. L., III. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006. 66, 11279-11286. PMID 17145873 Ballif, B. A., Cao, Z., Schwartz, D., Carraway, K. L., III, and Gygi, S. P. Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome 2006. Res 5, 2372-2379. PMID 16944949 Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L. III. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol 2007. 27, 2180-2188. PMID 17210635 Miller, J.K., Shattuck, D.L., Ingalla, E.Q., Yen, L., Borowsky, A.D., Young, L.J., Cardiff, R.D., Carraway, K.L., III, and Sweeney, C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer 2008. Res. 68, 8286-8294. PMID 18922900 Workman, H.C., Sweeney, C., and Carraway, K.L., III. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer 2009a. Res. 69, 2845-2852. PMID 19293191 Workman, H.C., Miller, J.K., Ingalla, E.Q., Kaur, R.P., Yamamoto, D.I., Beckett, L.A., Young, L.J., Cardiff, R.D., Borowsky, A.D., Carraway, K.L., Sweeney, C., and Carraway, K.L., III. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast 2009b. 11, R70. PMID 19761616