Broderick, Joan - Montana State University - Department of Chemistry and Biochemistry

个人简介

1987: Distinguished Achievement Award, WSU College of Arts and Sciences, Director's Award, WSU Honors Program, S. Towne Stephenson Scholar, WSU Honors Program 1987: National Science Foundation Graduate Fellowship 1992: American Cancer Society Postdoctoral Fellowship 2002: Saltman Lecturer, Metals in Biology Gordon Research Conference

研究领域

Bioinorganic Chemistry; Mechanisms of Metalloenzyme-mediated Reactions; Mechanisms of Biological Radical Reactions; Bioremediation

近期论文

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B. R. Duffus, S. Ghose, J. W. Peters, and J. B. Broderick, "Reversible H Atom Abstraction Catalyzed by the Radical SAM Enzyme HydG" J. Am. Chem. Soc. 2014, (Just Accepted). DOI: 10.1021/ja504618y J. B. Broderick, A.S. Byer, K. S. Duschene, B. R. Duffus, J. N. Betz, E. M. Shepard, and J. W. Peters, "H-Cluster assembly during maturation of the [FeFe]-hydrogenase" J. Biol. Inorg. Chem. 2014, 19, 747-757. DOI: 10.1007/s00775-014-1168-8 S. Ghose, J K. Hilmer, B. Bothner, and J. B. Broderick, "Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange" FEBS Lett. 2014, 588, 3023-3029. DOI: 10.1016/j.febslet.2014.06.011 E. M. Shepard, F. Mus, J. N. Betz, A. S. Byer, B. R. Duffus, J. W. Peters, and J. B. Broderick, "[FeFe]-Hydrogenase Maturation" Biochemistry 2014, 53, 4090-4104. DOI: 10.1021/bi500210x S. C. Silver, D. J. Gardenghi, S. G. Naik, E. M. Shepard, B. H. Huynh, R. K. Szilagyi, and J. B. Broderick, "Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase" J. Biol. Inorg. Chem. 2014, 19, 465-483. DOI: 10.1007/s00775-014-1104-y K. A. Shisler, and J. B. Broderick, "Glycyl radical activating enzymes: Structure, mechanism, and substrate interactions" Arch. Biochem. Biophys. 2014, 546, 65-71. DOI: 10.1016/j.abb.2014.01.020 J. B. Broderick, B. R. Duffus, K. S. Duschene, and E. M. Shepard, "Radical S-Adenosylmethionine Enzymes" Chem. Rev. 2014, 114, 4229-4317. DOI: 10.1021/cr4004709 A. V. Crain and J. B. Broderick, "Pyruvate Formate-Lyase and its Activation by Pyruvate Formate-Lyase Activating Enzyme" J. Biol. Chem. 2014, 289, 5723-5729. 10.1074/jbc.M113.496877 R. C. Driesener, B. R. Duffus, E. M. Shepard, I. R. Bruzas, K. S. Duschene, N. J.-R. Coleman, A. P. G. Marrison, E. Salvadori, C. W. M. Kay, J. W. Peters, J. B. Broderick, and P. L. Roach, "Biochemical and kinetic characterization of radical AdoMet enzyme HydG" Biochemistry 2013, 52, 8696-8707. DOI: 10.1021/bi401143s A. V. Crain and J. B. Broderick, "Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP+ oxidoreductase and pyruvate fomate-lyase activating enzyme" Biochim. Biophys. Acta 2013, 1834, 2512-2519. DOI: 10.1016/j.bbapap.2013.08.014 D. W. Mulder, M. W. Ratzloff, E. M. Shepard, A. S. Byer, S. M. Noone, J. W. Peters, J. B. Broderick, and P. W. King, "EPR and FTIR Analysis of the Mechanism of H2 Activation by [FeFe]-Hydrogenase HydA1 from Chlamydomonas reinhardtii" J. Am. Chem. Soc. 2013, 135, 6921-6929. DOI: 10.1021/ja4000257 K. A. Shisler, and J. B. Broderick, "Emerging themes in radical SAM chemistry" Curr. Opin. Struct. Biol. 2012, 22, 701-710. DOI: 10.1016/j.sbi.2012.10.005 N. Joshi, E. M. Shepard, A. S. Byer, K. D. Swanson, J. B. Broderick, and J. W. Peters, "Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF" FEBS Lett. 2012, 586, 3939-3943. DOI: 10.1016/j.febslet.2012.09.028 R. U. Hutcheson and J. B. Broderick, "Radical SAM enzymes in methylation and methylthiolation" Metallomics 2012, 4, 1149-1154. DOI: 10.1039/c2mt20136d J. W. Peters and J. B. Broderick, "Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion" Annu. Rev. Biochem. 2012, 81, 429-450. DOI: 10.1146/annurev-biochem-052610-094911 B. R. Duffus, T. L. Hamilton, E. M. Shepard, E. S. Boyd, J. W. Peters, and J. B. Broderick, "Radical AdoMet enzymes in complex metal cluster biosynthesis" Biochim. Biophys. Acta 2012, 1824, 1254-1263. DOI: 10.1016/j.bbapap.2012.01.002 S.-H. Kim, C. Harzman, J. K. Davis, R. Hutcheson, J. B. Broderick, T. L. Marsh, and J. M. Tjedje, "Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction," BMC Microbiology, 2012, 12, 21. DOI: 10.1186/1471-2180-12-21 A. Dey, Y. Peng, W. E. Broderick, B. Hedman, K. O. Hodgson, J. B. Broderick, and E. I. Solomon, "S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate Formate-Lyase Activating Enzyme: Nature of Interaction between the Fe4S4 Cluster and SAM and its Role in Reactivity" J. Am. Chem. Soc. 2011, 133, 18656-18662. DOI: 10.1021/ja203780t D. W. Mulder, E. M. Shepard, J. E. Meuser, N. Joshi, P. W. King, M. C. Posewitz, J. B. Broderick, and J. W. Peters "Insights into [FeFe]-Hydrogenase Structure, Mechanism, and Maturation," Structure, 2011, 19, 1038-1052. DOI: 10.1016/j.str.2011.06.008 E. M. Shepard, E. S. Boyd, J. B. Broderick, and J. W. Peters, "Biosynthesis of complex iron-sulfur enzymes," Curr. Opin. Chem. Biol. 2011, 15, 319-327. DOI: 10.1016/j.cbpa.2011.02.012