Lewis, Jamal - University of California, Davis - Department of Biomedical Engineering

个人简介

Ph.D., Biomedical Engineering, University of Florida, 2012 M.S., Biomedical Engineering, North Carolina State University, 2007 B.S., Chemical Engineering, Florida A&M University, 2004

研究领域

Biomedical engineers, now armed with a deeper understanding of immunobiology, have taken aim at modulating host immune responses to desired outcomes for improved diagnostic and therapeutic applications. Moreover, there is now a focus on developing biomaterial systems that harness the innate host immune responses to elicit beneficial and functional effects for biomedical applications. Research efforts in the Immuno-modulatory Biomaterials Lab are focused on engineering novel, biomaterial systems to harness and manipulate the innate functionality of phagocytic immune cells (particularly dendritic cell) in a precise spatial and temporal manner, ultimately for therapeutic applications in immune-related conditions (e.g. type 1 diabetes, rheumatoid arthritis and transplant rejection). Research aims also include the elucidation of biomaterial-immune cell interactions, which could be instructive for innovative biomedical device design. Currently, research efforts in the Lewis lab are centered on: Investigation and translation of a particulate platform system for autoimmune disease therapy Development of biologically-inspired polymers for immune modulation Understanding controlled non-lytic exocytosis in phagocytic cells Uncovering the role of dendritic cells in the foreign body response to materials

近期论文

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J Sumerel, J Lewis, A Doraiswamy, L F Deravi, D W Wright, R J Narayan. Piezoelectric ink jet processing of materials for biological and medical applications. Biotechnology Journal. August 2006. Vol. 1. 976-987 J S Lewis, S D Gittard, R J Narayan, C J Berry, R L Brigmon, R Ramamurti, R N Singh. Assessment of Microbial Biofilm Growth on Nanocrystalline Diamond Coatings Using a CDC Biofilm Reactor. J. Manuf. Sci. Eng. June 2010 132, 030919. Jamal S. Lewis, Patrick C. Crooks, Toral Zaveri, Benjamin G. Keselowsky. Microparticle surfacemodification approaches for efficient dendritic cell-targeting drug delivery for auto-immune vaccine applications. Biomaterials. June 2012. Vol. 33; 7221 – 7232 Abhinav P. Acharya, Jamal S. Lewis, Benjamin G. Keselowsky. High-throughput Parallel Particle Production for Combinatorial Encapsulation of Hydrophobic Molecules. Biomaterials. April 2013. Vol. 34; 3422 – 3430 Jamal S. Lewis, Natalia V. Dolgova, Thomas J. Chancellor, Abhinav A. Acharya, Jerome V. Karpiak, Tanmay P. Lele, Benjamin G. Keselowsky. Dendritic cell activation is influenced by cyclic mechanical strain when cultured on adhesive substrates. Biomaterials. August 2013. Vol. 34; 9063 – 9070 Jamal S. Lewis, Krishnendu Roy, Benjamin G. Keselowsky. Materials that harness and modulate the immune system. MRS Bulletin. January 2014. Vol. 39; 25 – 34. Jamal S. Lewis, Chris Roche, Ying Zhang, Benjamin G. Keselowsky. Microsphere technology offers combinatorial and local drug delivery to dendritic cells for enhancement of suppressive function. J. Mater. Chem. B. 2:2562-2574. (DOI: 10.1039/C3TB21460E). January 2014. Toral Zaveri, Jamal S. Lewis, Natalia Dolgova, Michael Clare-Salzler, Benjamin G. Keselowsky. Integrin-Directed Modulation of Macrophage Response to Biomaterials. Biomaterials. January 2014. Vol. 35; 3504 – 3515. Lewis, J.S, Dolgova, N.V., Zhang, Y., Xia, C.Q., Wasserfall, C.H., Atkinson, M.A., Clare-Salzler, M.J., Keselowsky, B.G. (In press, 2015) A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice. Clinical Immunology. (doi:10.1016/j.clim.2015.03.023) Young Mee Yoon, Jamal S. Lewis, Matthew R. Carstens, Martha Campbell-Thompson, Clive H. Wasserfall, Mark A. Atkinson, Benjamin G. Keselowsky. A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice. Scientific Reports. August 2015. Vol. 5; #13155 (doi:10.1038/srep13155). Abhinav P Acharya, Matthew Carstens, Jamal S. Lewis, Natalia Dolgova, Chang Qing Xia, Michael Clare-Salzler, Benjamin G. Keselowsky. A cell-based microarray to investigate the combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation. In review – Journal of Materials Chemistry B.