Segal, David - University of California, Davis - College of Biological Sciences

研究领域

Genome and Epigenome Editing for the Study and Treatment of Disease

近期论文

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Bailus, B.J., Pyles, B., McAlister, M.M., O’Geen, H., Lockwood, S.H., Adams, A.A., Trang Nguyen J.T., Berman R.F., and Segal, D.J. (2016) Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 24:548-555. Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A., Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Wheelock V, Segal DJ, and Nolta, JA. Allele-specific reduction of the mutant huntingtin allele using transcription activator-like effectors in human Huntington’s disease fibroblasts. Cell Transplant. 25:677-686. Tak, Y.G., Hung, Y., Yao, L., Grimmer, M.R., Do, A., Bhakta, M.S., O'Geen, H., Segal, D.J., Farnham, P.J. (2016) Effects on the transcriptome upon deletion of distal elements are not correlated with the size of H3K27Ac peaks in human cells. Nucleic Acids Res. pii: gkv1530. O’Geen, H., Yu, A.S., and Segal, D.J. How specific is CRISPR/Cas9 really? (2015) Current Opinions in Chemical Biology. 29:72–78. O'Geen, H., Henry, I.M., Bhakta, M.S., Meckler, J.F., Segal, D.J. (2015) A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. Nucleic Acids Res. 43:3389-3404. Bailus, B.J., Segal, D.J. (2014) The Prospect of Molecular Therapy for Angelman Syndrome and Other Autism Spectrum Disorders. BMC Neurosci, 15:76. Lockwood, S.H., Guan, A., Yu, A.S., Zhang, C., Zykovich, A., Korf, I., Rannala, B., Segal, D.J. (2014) The Functional Significance of Common Polymorphisms in Zinc Finger Transcription Factors. G3, pii: g3.114.012195. Barrilleaux, B., Burow, D., Lockwood, S., Yu, A., Segal, D.J., Knoepfler, P. (2014) Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 9:e101151. Johnson, L.M., Du, J., Hale, C.J., Bischof, S, Feng, S., Chodavarapu, R.K., Zhong, X., Marson, G., Pellegrini, M., Segal, D.J., Patel, D.J., Jacobsen, S.E. (2014) SRA/SET domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature, 507:124-128. Bailus, B.J., Segal, D.J. (2014) The Prospect of Molecular Therapy for Angelman Syndrome and Other Autism Spectrum Disorders. BMC Neurosci, 15:76. Lockwood, S.H., Guan, A., Yu, A.S., Zhang, C., Zykovich, A., Korf, I., Rannala, B., Segal, D.J. (2014) The Functional Significance of Common Polymorphisms in Zinc Finger Transcription Factors. G3, pii: g3.114.012195. Segal, D.J. and Meckler, J.F., (2013) Genome Engineering at the Dawn of the Golden Age, Annu. Rev. Genomics Hum. Genet, 14:135–158. Meckler, J.F., Bhakta, M.S., Kim, M-S., Ovadia, R., Habrian, C.H., Zykovich, A., Yu, A., Lockwood, S.H., Morbitzer, R., Elsäesser, J., Lahaye, T., Segal, D.J., and Baldwin, E.P. (2013) Quantitative Analysis of TALE-DNA Interactions Suggests Polarity Effects, Nucleic Acids Res, 41:4118-4128. Bhakta, M.S., Henry, I.M., Ousterout, D.G., Theva Das, K., Lockwood, S.H., Meckler, J.F., Wallen, M.C., Zykovich, As, Yu, Y., Leo, H., Xu, L., Gersbach, C.A. and Segal, D.J. (2013) Highly Active Zinc-Finger Nucleases by Extended Modular Assembly, Genome Research, 23:530-538. Owens, J.B., Mauro, D., Stoytchev, I., Bhakta, M.S., Kim, M.-S., Segal, D.J. and Moisyadi, S. (2013) Transcription activator like effector (TALE) directed piggyBac transposition in human cells. Nucleic Acids Res, 41:9197-9207. Meier, J.L., Yu, A., Korf, I., Segal, D.J. and Dervan, P.B. (2012) Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing, J Am Chem Soc. 134:17814-17822. Zykovich, A., Korf, I. and Segal, D.J. (2009) Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Res. 37:e151. Kim, M.-S., Stybayeva, G., Lee, J.Y., Revzin, A., and Segal, D.J. (2011) A zinc finger protein array for the visual detection of pathogen-specific DNA sequences. Nucleic Acids Res. 39:e29. Shimizu, Y., Şöllü, C., Meckler, J. M., Adriaenssens, A., Zykovich, A., Cathomen, T., and Segal, D.J. (2011) Adding Fingers To An Engineered Zinc Finger Nuclease Can Reduce Activity. Biochemistry, 50:5033-5041 Mackay, J.P., Font, J., and Segal, D.J. (2011) The prospects for designer single-stranded RNA-binding proteins. Nature Struct Mol Biol, 18:256-261 Furman, J. L., Badran, A. H., Ajulo, O., Porter, J. R., Stains, C. I., Segal, D. J., and Ghosh, I. (2010) Toward a General Approach for RNA-Templated Hierarchical Assembly of Split-Proteins, J Am Chem Soc. 132:11692-11701. Szczepek, M., Brondani, V., Büchel, J., Serrano, L., Segal, D.J. and Cathomen, T. (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc finger nucleases. Nat. Biotechnol., 25:786-793. Alwin, S., Gere, M. B., Guhl, E., Effertz, K., Barbas, C. F., 3rd, Segal, D. J., Weitzman, M. D., and Cathomen, T. (2005). Custom Zinc-Finger Nucleases for Use in Human Cells. Mol Ther. Carroll, D., Morton, J.J., Beumer, K.J. & Segal, D.J. (2006) Construction and Testing of Zinc Finger Nucleases. Nat. Protocols, 1:1329-1341.