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研究领域

Neuroendocrine regulation of feeding behavior, body weight and glucose control Mechanisms linking psychological stress and metabolic disease Nuclear receptors

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Ulrich-Lai YM, Ryan KK (2014) Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications. Cell Metabolism, 19(6): 910-925. Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns, R, Wilson-Perez HE, Sandoval DA, Kohli R, Backhed F, Seeley RJ (2014) FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature, 509: 183-188. Ryan KK, Mul JD, Clemmensen C, Egan AE, Begg DP, Halcomb K, Seeley RJ, Herman JP, Ulrich-Lai YM (2014) Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress. Psychoneuroendocrinology, 42:98-105. Clemmensen C, Smajilovic S, Smith EP, Woods SC, Bräuner-Osborne H, Seeley RJ, D’Alessio DA, Ryan KK (2013) Oral L-arginine elicits GLP-1 secretion to improve glucose tolerance in male mice. Endocrinology. 154(11): 3978-3983. Ryan KK, Seeley RJ (2013) Food as a hormone. Science. 339: 918-919. Ryan KK, Grayson BE, Jones KR, Schneider AL, Woods SC, Seeley RJ, Herman JP, Ulrich-Lai YM (2012) Physiologic responses to acute psychological stress are reduced by the PPARγ agonist Rosiglitazone. Endocrinology. 153(3): 1279-1287. Ryan KK, Woods SC, Seeley RJ (2012) Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metabolism. 15(2): 137-149. Ryan KK, Li B, Grayson BE, Matter EK, Woods SC, Seeley RJ (2011) A role for central nervous system PPARγ in the regulation of energy balance. Nature Medicine. 17(5): 623-626.

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