Bodine, Sue - University of California, Davis - College of Biological Sciences

研究领域

Molecular and cellular mechanisms that regulate skeletal muscle growth and the maintenance of skeletal muscle mass and function. Integration of in vivo biology/pharmacology, mouse genetics, cell biology/biochemistry and molecular biology techniques to identify signaling pathways responsible for muscle atrophy that occurs during inactivity, various diseases processes and aging. Neuomuscular physiology and neurodegenerative diseases. Integrative physiology: interrelationships between muscle and other systems such as adipose tissue in the regulation of metabolism, glucose regulation and various diseases. Neuromuscular physiology, integrative muscle biology, regulation of muscle size, mechanisms responsible for muscle atrophy following disuse, disease, and aging.

近期论文

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Hwee DT, Bodine SC. (2009) Age-related deficit in load-induced skeletal muscle growth. J Gerontol A Biol Sci Med Sci. 64(6):618-28. Sitnick, M., Bodine, S.C. and Rutledge, J.C. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J. Physiology London 587: 5753-5765, 2009. Baehr, L.M., Furlow, J.D., and Bodine, S.C. Muscle Sparing in Muscle Ring Finger-1 Null Mice: Response to Synthetic Glucocorticoid. Journal of Physiology (Lond). 589: 4759-4776, 2011. Bodine, S.C. and Baar, K. Analysis of Muscle Hypertrophy in Models of Skeletal Muscle Overload. Methods Molecular Biology 798: 213-229, 2012. Files, D.C. D’Alessio, FR, Johnston, LF, Kesari, P, Aggarwal, NR, Garibaldi, BT, Mock, JR, Simmers JL, Degorordo A, Murdoch, J, Willis MS, Patterson C, Tanskersley, CG, Messi, ML, Liu, C, Delbano, O, Furlow, JD, Bodine, SC, Cohn, RD, King, LS, and Crow, MT. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting. Am J Respir Crit Care Med 185: 825-834, 2012 (Epub 2012 Feb 3]. Watson, ML, Baehr, LM, Reichardt, HM, Tuckermann, JP, Bodine, SC and Furlow JD. Muscle Specific Deletion of the Glucocorticoid receptor Prevents Synthetic Glucocorticoid Induced Skeletal Muscle Atrophy. Amer. J. Physiol: Endo Metab, 302: E1210-1220, 2012. Bodine, S.C. Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy. Invited Commentary/ Mini Review: Experimental Neurology, 248: 129-135, 2013. Bodine, S.C. Disuse-Induced Muscle Wasting. Invited Review: International J. Biochem Cell Biol. 2013 Hwee, DT, Baehr, LM, Philp, A., Baar, K and Bodine, SC. Maintenance of Muscle Mass and Load-Induced Growth in Muscle Ring Finger 1 Null Mice with Aging. Aging Cell. 2013 Aug 14. doi: 10.1111/acel.12150. [Epub ahead of print] Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC. (2008) The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab.295(4):E785-97. Kline, W.O., Panaro, F.J., Yang, H., and Bodine, S.C. (2007) Rapamycin inhibits the growth and muscle sparing effects of clenbuterol. J. Appl. Physiol. 102: 740-741. Baar, K., Nader, G. and Bodine, S.C. (2006) Resistance exercise, muscle loading/unloading and the control of muscle mass. Essays in Biochemistry. 38:1950-1957. Bodine, S.C. (2006) mTOR signaling and molecular adaptations to resistance exercise. Med Sci Sports Exerc. 38:1950-1957. Reynolds, T.H., Bodine, S.C., and Lawrence, J.C. (2002) Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin, amino acids, and skeletal muscle loading. J. Biol. Chem. 277: 17657-17662. Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keogh, T.W., Farrar, R.P., Bodine, S.C., and Anderson, N.L. (2002) Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy. Proteomics 2: 543-550. Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K.-L., Nunez, L., Clarke, B., Poueymirou, W., Panaro, F., Na, E., Dharmarajan, K., Pan, Z-Q., Valenzuela, D.M., .DeChiara, T.M., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294:1704-1708. Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J.C., Glass, D.J., and, Yancopoulos, G.D. (2001) The AKT/mTOR pathway is a critical regulator of skeletal muscle hypertrophy, and can prevent muscle atrophy in vivo. Nature Cell Biology 3: 1014-1019. Rommel, C., Bodine, S.C., Clarke, B.A., Rossman, R., Nunez, L., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways. Nature Cell Biology 3: 1009-1013.