Rodriguez, Raymond - University of California, Davis

研究领域

Nutritional genomics is the study of diet-gene interactions on a whole genome scale with the goal of developing innovative solutions to disease prevention, diagnosis, and treatment. There are a few already known well-characterized examples of diet-gene interactions affecting human health: e.g., lactose intolerance, phenylketonuria, galatosemia, gluten-sensitive enteropathy, and familial hypercholesterolemia. In these classic examples, disease-specific genetic polymorphisms are identified, their population distributions are known, and clinical dietary guidelines are developed for disease prevention and treatment. In addition to these disease conditions, many common chronic diseases: e.g., obesity, diabetes, cardiovascular disease, breast cancer, and prostate cancer, are also associated with diet as a risk or course-modifying factor. However, the genetic background of these polygenic diseases is more complex and the mechanistic explanations of the diet-gene interactions could become possible only with the recent advances in post-genomic ( omic ) technologies. The chemopreventive properties of a soy-based polypeptide is being investigated using microarray analysis of human cells and small animal models. This peptide has been shown to remodel chromatin structure and to up-regulate genes related to tumor suppression, apoptosis, cell cycle control and DNA repair.

近期论文

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Albeck, J.G., Taha, A.Y., Ori-McKenney, K.M., Recanzone, G.H., Stradleigh, T.W., Hernandez, B.C., Nord, A.S., Tang, F-Y, Chiang, E-P, Rodriguez. R.L., and Cruz-Orengo, L. 2016. Impact of Diet-derived Signaling Molecules on Human Cognition: Exploring the Food-Brain Axis. Nature Science of Food. Submitted. Kalimuthu Karuppanan, Sifti Duhra-Gill, Muchena J. Kailemia, My L. Phu, Carlito Lebrilla, Abhaya M. Dandekar, Raymond L. Rodriguez, Somen Nandi, Karen McDonald. 2016. Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. Intl. J. Molec. Sci. In Press. Corbin, J.M., Hashimoto, B.I., Karuppanan, K., Kyser, Z. R., Wu, L., Roberts, B.A., Noe, A.R., Rodriguez, R.L., McDonald, K.A., and Nandi, S. (2016) Semicontinuous bioreactor production of recombinant butyrylcholinesterase in transgenic rice cell suspension cultures. Frontiers in Plant Science. In Press. Alkanaimsh, S., Karuppanan, K., Guerrero, A., Tu, A., Hashimoto, B., Hwang, M-S, Phu, M., Arzola, L., Lebrilla, C., M. Dandekar, A., Falk, B.W., Nandi, N., Rodriguez, R.L., and McDonald, K. (2016) Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana. Frontiers in Plant Science,16:7:743. Nandi, S., Thota, S., Nag, A., Divyasukhananda, S., Goswami, P., Aravindakshan, A., Rodriguez, R.L., and Mukherjee, B. (2016). Computing for Rural Empowerment: Enabled by Last-Mile Telecommunications. IEEE Communications Magazine 54(6): 102-109. DOI: 10.1109/MCOM.2016.7498095 Chiang, E-P, Tsai, Y., Kuo, Y-H, Pai, M-H, Chiu, H-L, Rodriguez, RL, Tang, F-Y. 2014. Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways. PLOS One, DOI:10.1371 Dawson, K., Zhao, L., Adkins, Y., Vemuri, M., Rodriguez, R.L., Gregg, J.P., Kelley, D. S. and Hwang, D.H. 2012. DHA supplementation suppresses LDL receptor and oxidized LDL receptor gene expression in blood cells from hypertriglyceridemic men. J. Nutritional Biochem. 23:616–621 Langridge, W., Odumosu, O., Nandi, S., Rodriguez, R.L., DeLeon, M. and Cordero-MacIntyre, Z. 2012. Mucosal Vaccination against Enteric Pathogens in the Developing World. British Journal of Medicine and Medical Research. 2:260-291. Nutritional Genomics: Impact of Dietary Regulation of Gene Function on Human Disease. Bidlack, W. and R. L. Rodriguez, Taylor and Francis/CRC Press, December 2011. Jun, H-J, Kim, S., Dawson, K., Choi, D-W, Kim, J-S, Rodriguez, R. L. and Lee, S-J. 2011. Effects of Acute Oral Administration of Vitamin C on the Mouse Liver Transcriptome. J. Med. Food. 14:1-14. Galvez, A.F., Huang, L., Magbanua, M.M.J. Dawson, K., Nandi, S. and R. L. Rodriguez. 2011. Diet-influenced Chromatin Modification and Expression of Chemopreventive Genes by the Soy Peptide, Lunasin, in Nutritional Genomics: Dietary Regulation of Gene Function on Human Disease. Bidlack, W. and R. L. Rodriguez, eds. Taylor and Francis/CRC. Galvez, A.F., Huang, L., Magbanua, M.M.J. Dawson, K. R. L. Rodriguez. 2011. Differential Expression of Thrombospondin (THBS1) in Turmorigenic and Nontumorigenic Prostate Epithelial Cells in Response to a Chromatin-Binding Soy Peptide. Nutrition and Cancer. 63(4):623-636. Jun, H-J, Chung, M-J, Dawson, K. Rodriguez, R.L., Houng, S-J, Cho, S-Y, Jeun, J., Kim, J-Y, Kim, K-H, Park, K. W., Kim, C.-T. and Lee, S-J. 2010. Nutrigenomic Analysis of Hypolipidemic Effects of Agastache rugosa Essential Oils in HepG2 Cells and C57BL/6 Mice. Food Sci. Biotechnol. 19(1):219-227. Park, K-H and Lee, S-J. 2010. Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes. Eur. Food Res. Technol. DOI 10.1007/s00217-010-1251-5. Nelson, E.C., Rodriguez, R.L., Dawson, K. Galvez, A. and Evans, C. 2008. The interaction of genetic polymorphisms with lifestyle factors: implications for Dietary Prevention. Nutrition and Cancer 60:301-312. Choi, Y-M, Jun, H-J, Dawson, K., Rodriguez, R.L., Roh, M-R, Jun, J., Choi, C-H, Choi, Shim, J-H, Lee, C-H, Lee, S-J, Dawson, K., Rodriguez, R.L., Hawkes, W.C. and Malyj, W. 2006. Biocomputation and the analysis of complex data sets in nutritional genomics, in Nutrigenomics: Discovering the Path to Personalized Nutrition, John Wiley & Sons, New Jersey, pp. 375-401. Kaput, J. and Rodriguez, R.L. 2006. Nutrigenomics: Discovering the Path to Personalized Nutrition, John Wiley & Sons, New Jersey.