Ori-Mckenney, Kassandra - University of California, Davis

研究领域

MNB/DYRK1a Kinase How does the Down Syndrome critical kinase, MNB/DYRK1a, regulate the microtubule cytoskeleton directly or indirectly during neuronal development and maintenance? How is MNB/DYRK1a regulated both temporally and spatially within a cell? Neuronal Cytoarchitecture How is the cytoskeleton organized and regulated in order to produce a distinct neuronal morphology? Tubulin Phosphorylation How does phosphorylation of tubulin affects its ability to polymerize into microtubules?

近期论文

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Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AR, Jan YN. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron, 90, 551-63 (2016). Ori-McKenney KM, Jan LY, Jan YN. Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron, 76, 921-30 (2012). Harms M, Ori-McKenney KM, Scoto M, Tuck E, Bell S, Ma D, Masi S, Allred P, Al-Lozi, M, Reilly M, Miller L, Jani-Acsadi A, Shy M, Pestronk A, Muntoni F, Vallee RB, Baloh R. Mutations in the tail domain of cytoplasmic dynein (DYNC1H1) cause motor neuron disease in humans. Neurology, 78, 1-7 (2012). Ori-McKenney KM*, Xu, J*, Gross SP, Vallee RB. A neurodegenerative mutation reveals novel features of cytoplasmic dynein motor regulation. Nature Cell Biology, 12, 1228-34 (2010). (*Co-first authors)