McKenney, Richard J. - University of California, Davis

研究领域

Motor proteins and the cytoskeleton My lab is interested in the fascinating world of molecular movement. We study how cells internally organize using molecular motor proteins. In particular, we focus on the microtubule cytoskeleton and the motor proteins that use this filament system for transport (kinesins and dyneins). We are interested in allosteric regulation of motor protein movement, how motor activity is balanced and coordinated, and how dysfunction in motor activity leads to human diseases such as cancer and neurodegeneration. The lab combines advanced molecular biology, biochemistry and single-molecule TIRF microscopy to address these problems.

近期论文

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Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron, 90, 1-13 (2016). McKenney, RJ, Huynh, W, Vale, RD, Sirajuddin, M. (2016). Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility. The EMBO J. Mar 11. Epub ahead of print. Faculty of 1000: Rated “Good” http://f1000.com/prime/726213598 Perspective Article: Allan, V. J. (2016). A tale of two α-tubulin tails The EMBO Journal. DOI 10.15252/embj.201694325 McKenney, RJ, Huynh, W, Tanenbaum, ME, Bhabha, G, and Vale, RD (2014). Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. Jul 18;345(6194): 337-41. PMID: 25035494. Yi, JY, Ori-McKenney, KM, McKenney, RJ, Vershinin, M, Gross, SP, & Vallee, RB (2011). High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. Journal of Cell Biology, 195(2), 193–201. PMID: 22006948. Kunwar, A., Tripathy, SK, Xu, J, Mattson, MK, Anand, P, Sigua, R, Vershinin, M, McKenney, RJ, Yu CC, & Gross, SP (2011). Mechanical stochastic tug-of- war models cannot explain bidirectional lipid-droplet transport. PNAS, 108(47), 18960-18965. PMID: 22084076. McKenney, RJ*, Vershinin, M*, Kunwar, A, Vallee, RB, & Gross, SP (2010). LIS1 and NudE induce a persistent dynein force-producing state. Cell, 141(2), 304–314. PMID: 20403325 (*equal contribution). Faculty of 1000: Rated “Very Good” http://f1000.com/prime/3110957 Stehman, SA, Chen, Y, McKenney, RJ, & Vallee, RB (2007). NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. Journal of Cell Biology, 178(4), 583–594. PMID: 17682047. Suzuki, SO, McKenney, RJ, Mawatari, S-Y, Mizuguchi, M, Mikami, A, Iwaki, T, Goldman, JE, Canoll, P, & Vallee RB. (2007). Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathologica, 113(5), 591– 599. PMID: 17221205. Bahassi, EM, Myer, DL, McKenney, RJ, Hennigan, RF, & Stambrook, PJ (2006). Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutation research, 596(1-2), 166–176. PMID: 16481012.