研究领域
R-loop biology in mammals
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Lim Y.W., Sanz L., Xu X., Hartono S.R., and Chédin F. (2015). DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. eLife. In press
Yang Y.Z., McBride K., Hensley K., Yue L., Chédin F., and Bedford M.T. (2014). Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R-loop accumulation. Molecular Cell. 53(3):484-497.
Loomis E.W., Sanz L.A., Chédin F., and Hagerman P.J. (2014). Transcription-associated R-loop formation across the human FMR1 CGG-repeat region. PLoS Genetics. 10(4):e1004294
Powell W. T., Coulson R., Crary F. K., Wong S., Gonzales M. L., Adams S., Yasui D.H., Chédin F., and LaSalle J. M. (2013). Topotecan stabilizes R-loops to inhibit transcription in the Prader-Willi/Angelman imprinted locus. Proceedings of the National Academy of Sciences USA; 110(34):13938-13943
Ginno P. A., Lim Y.W., Lott P., Korf I., and Chédin* F. (2013). GC skew at the 5’ and 3’ Ends of Human Genes Links R-loop Formation to Epigenetic Regulation and Transcription Termination. (2013). Genome Research. 23(10):1590-1600
Gordon C.A., Hartono S.R., and Chédin* F. (2013) Inactive DNMT3B splice variants modulate de novo DNA methylation. PLoS One 2013 Jul 19;8(7):e69486.
Ginno P. A., Lott P., Christensen H. C., Korf I., and Chédin* F. (2012) R-loop formation is a distinctive characteristic of unmethylated human CpG islands. Molecular Cell, 45(6):814-825.
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