Xu, Lifeng - University of California, Davis - College of Biological Sciences

研究领域

Telomeres are the protective nucleoprotein structures at the ends of linear eukaryotic chromosomes. Telomere dysfunction contributes to cancer progression and aging. Our laboratory employs molecular and cytological approaches to study telomere maintenance in human normal cells and cancer cells.

近期论文

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Nera, B., Huang, H.S., Lai, T., Xu, L. Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nature Communications DOI: 10.1038/ncomms10132 (2015) Frank, A.K., Tran, D.C., Qu, R.W., Stohr, B.A., Segal, D.J., Xu, L. The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLOS Genetics 11(7): e1005410 (2015) Bhakta, M.S., Henry, I.M., Ousterout, D.G., Das, K.T., Lockwood, S.H., Meckler, J.F., Wallen, M.C., Zykovich, A., Yu, Y., Leo, H., Xu, L., Gersbach, C.A., Segal, D.J. Highly active zinc-finger nucleases by extended modular assembly. Genome Res. 23(3):530-8 (2013) Xu, L., Li, S., Stohr, B.A. The role of telomere biology in cancer. Annu Rev Pathol. 8:49-78 (2013) Stohr, B.A., Xu, L., Blackburn, E.H. The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion. Mol. Cell 39: 307-314 (2010). Wang, X., Kam, Z., Carlton, P.M., Xu, L., Sedat, J.W., Blackburn, E.H. Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy. Epigenetics Chromatin. 1(1):4. (2008) Xu, L and Blackburn, E.H. Human cancer cells harbor t-stumps, a distinct class of extremely short telomeres. Mol. Cell 28: 315-327 (2007) Xu, L and Blackburn, E.H. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J. Cell Biol. 167: 819-830 (2004) Ly, H.*, Xu, L.*, Rivera, M.A., Parslow, T.G., Blackburn, E.H. A role for a novel ‘transpseudoknot’ RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev. 17:1078-1083 (2003) Kim, M., Xu, L., Blackburn, E.H. Catalytically active human telomerase mutants with allele-specific biological properties. Exp. Cell Res. 288:277-287 (2003) Comolli, L.R., Smirnov, I., Xu, L., Blackburn, E.H., James, T.L. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad. Sci. USA. 99: 16998-17003 (2002) Tao, W., Pennica, D., Xu, L., Kalejta, R.F., Levine A.J. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 15: 1796-1807 (2001) Xu, L., Corcoran, R.B., Welsh, J.W., Pennica, D., Levine A.J. WISP-1 is a Wnt-1 and ß-catenin responsive oncogene. Genes Dev. 14: 585-595 (2000)