Kennedy, Michael A. - Miami University - Department of Chemistry and Biochemistry

个人简介

Education B.S., Muskingum College (1984) Ph.D., University of South Carolina (1989) Post-Doc, University of California, San Diego Post-Doc, University of Washington

研究领域

Structural biology, structural genomics, DNA repair, NMR-based metabonomics, NMR spectroscopy, x-ray crystallography

近期论文

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Bo Wang, Sulaiman Sheriff, Ambikaipakan Balasubramaniam, Michael A. Kennedy “NMR based metabonomics study of NPY Y2 Receptor activation in SK-N-BE2, a human neuroblastoma cell line” Metabolomics, in press, 2015. Yunhuang Yang, Theresa A. Ramelot, Hsiau-Wei Lee, Rong Xiao,John K. Everett,Gaetano T. Montelione, James H. Prestegard, Michael A. Kennedy, NMR Structure Note: Solution structure of a fragment (175-257) of CV_0373 protein from Chromobacterium violaceum adopts a winged helix-turn-helix (wHTH) fold. Journal of Biomolecular NMR, in press, 2014. Yunhuang Yang, Theresa A. Ramelot, Hsiau-Wei Lee, Rong Xiao,John K. Everett,Gaetano T. Montelione, James H. Prestegard,Michael A. Kennedy, “NMR Structure Note: Solution structure of the free Zalpha domain of human DLM-1 (ZBP1/DAI), a Z-DNA binding domain” Journal of Biomolecular NMR, in press, 2014. Sherif I. Elshahawi, Theresa A. Ramelot, Jayaraman Seetharaman, Jing Chen, Shanteri Singh, Yunhuang Yang, Kari Pederson, Madan K. Kharel, Rong Xiao, Thomas B. Acton, John K. Everett, Ragothaman M. Yennamalli, Fengbin Wang, James H. Prestegard, Scott Lew, Liang Tong, Gaetano T. Montelione, Michael A. Kennedy, Craig A. Bingman, Haining Zhu, George N. Phillips Jr, andJon S. Thorson, Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19, ACS Chemical Biology, 9(10):2347-58, 2014. Zhanquan Shi, Bo Wang, Tafadzwa Chihanga, Michael A. Kennedy, Georg F. Weber “Energy Metabolism during Anchorage Independence. Induction by Osteopontin-c”, PLOS ONE, 9(8), e105675, 2014. Bo Wang, Michael A. Kennedy “Principal component analysis of protein sequence clusters”, J. Struct. Funct. Genomics, 15, 1-11, 2014. DOI Laura A. Lavery, James R. Partridge, Theresa A. Ramelot, Daniel Elnatan, Michael A. Kennedy, David A. Agard, "Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism", Molecular Cell 53(2), 330-343, 2014. DOI Zhanquan Shi, Mana Mirza, Bo Wang, Michael A. Kennedy, Georg F. Weber, “Osteopontin-a alters glucose homeostasis in anchorage independent breast cancer cells”, Cancer Letters, 344(1), 47-53, 2014. DOI Patrick Videau, Shuisong Ni, Orion S. Rivers, Blake Ushijima, Erik A. Feldmann, Loralyn M. Cozy, Michael A. Kennedy, and Sean M. Callahan, "Expanding the direct HetR regulon in Anabaena sp. strain PCC 7120", Journal of Bacteriology, 196(5), 1113-1121, 2014. DOI Theresa A. Ramelot, Yunhuang Yang, Indra D. Sahu, Hsiau-Wei Lee, Rong Xiao, Gary A. Lorigan, Gaetano T. Montelione, and Michael A. Kennedy, "NMR structure and MD simulations of the AAA protease intermembrane space domain indicates peripheral membrane localization within the hexaoligomer", FEBS Lett., 587(21), 3522-8, 2013. DOI Bo Wang, Zhanquan Shi, Georg F. Weber, and Michael A. Kennedy “Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data” Analytical and Bioanalytical Chemistry, 405(26), 8419-8429, 2013. DOI Bo Wang, Aaron M. Goodpaster and Michael A. Kennedy “Coefficient of Variation, Signal-to-Noise Ratio, and Effects of Normalization in Validation of Biomarkers from NMR-based Metabonomics Studies”, Chemometrics and Intelligent Laboratory Systems, 128, 9-16, 2013. DOI Surya VSRK Pulavarti, Yunfen He, Erik A. Feldmann, Alexander Eletsky,Thomas B. Acton, Rong Xiao, John K. Everett, Gaetano T. Montelione, Michael A. Kennedy, Thomas Szyperski "Solution NMR Structures Provide First Structural Coverage of the Large Protein Domain Family PF08369 and Complement Structural Coverage of Dark Operative Protochlorophyllide Oxidoreductase Complexes", Journal of Structural and Functional Genomics, 14, 119-126, 2013. DOI Lindsey E. Romick-Rosendale, Neil B. Patel, and Michael A. Kennedy1 “Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy”, Metabolomics, 10(1), 8-20, 2014. DOI Yunhuang Yang, Theresa A. Ramelot, Shuisong Ni, Robert M. McCarrick, Michael A. Kennedy “Applications of NMR-based PRE and EPR-based DEER spectroscopy to homodimer subunit exchange characterization and structure determination” Methods in Molecular Biology, 1091, 215-227, 2014. DOI Ardythe L. Morrow, Anne J. Lagomarcino, Kurt R. Schibler, Diana H. Taft, Zhuoteng Yu, Bo Wang, Michael Wagner, Dirk Gevers, Doyle V. Ward, Michael A. Kennedy, Curtis Huttenhower, David S. Newburg “Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants” Microbiome, 1:13, 2013. DOI Daniil V. Zaytsev, Jiufeng Fan, Xianchun Zhu, Madhumita Mukherjee, Shuisong Ni, Michael A. Kennedy, Borries Demeler, and Michael Y. Ogawa “Metal-binding properties of a self-assembled coiled coil: formation of a polynuclear Cd-thiolate cluster” J Inorganic Biochemistry, 119, 1-9, 2013.DOI Yunhuang Yang, Theresa A. Ramelot, Shuisong Ni, Robert M. McCarrick, Michael A. Kennedy “Measurement of Rate Constants for Homodimer Subunit Exchange Using Double Electron-Electron Resonance and Paramagnetic Relaxation Enhancement.” Journal Biomolecular NMR, 55(1), 47-58, 2013. DOI Theresa A. Ramelot, Paolo Rossi, Farhad Forouhar, Hsiau-Wei Lee, Yunhuang Yang, Shuisong Ni, Sarah Unser, Scott Lew, Jayararaman Seetharaman, Rong Xiao, Thomas B. Acton, John K. Everett, James H. Prestegard, John F. Hunt, Gaetano T. Montelione and Michael A. Kennedy “Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids, in open and closed conformations” Biochemistry, 51, 7239-49, 2012. DOI Erik A. Feldmann, Jayaraman Seetharaman, Theresa A. Ramelot, Scott Lew, Li Zhao, Keith Hamilton, Colleen Ciccosanti, Rong Xiao, Thomas B. Acton, John K. Everett, Liang Tong, Gaetano T. Montelione, Michael A. Kennedy “Solution NMR and X-ray crystal structure of Pspto_3016 from Pseudomonas syringae, a member of protein domain family PF04237 (DUF419) that adopts a “double wing” DNA binding motif” Journal of Structural and Functional Genomics, 13,155-162, 2012.DOI