Lin, Su-Ju - University of California, Davis - College of Biological Sciences

研究领域

Regulation of NAD+ homeostasis and cellular life span

近期论文

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S. -J. Lin, P. Defossez and L. Guarente. (2000) Life span extension by calorie restriction in S. cerevisiae requires SIR2 and NAD. Science 289:2126-8. S. -J. Lin, M. Kaeberlein, A. A. Andalis, L. A. Sturtz, P.-A. Defossez, V. C. Culotta, G. R. Fink and L. Guarente (2002) Calorie restriction extends life span by shifting carbon toward respiration. Nature 418:344-348. S. -J. Lin and L. Guarente (2003) NAD, a metabolic regulator of transcription, longevity and diseases. Current Opinion in Cell Biology 15:241-246. S. -J. Lin, E. Ford, M. Haigis, G. Liszt and L. Guarente (2004) Calorie restriction extends life span by lowering the NADH levels. Genes and Development 18:12-16. D. Lamming, M. Latorre, O. Medvedik, S. N. Wong, F. A. Tsang, C. Wang, S.-J. Lin* and D. A. Sinclair* (2005) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science 309:1861-64 L. Bordone, M. C. Motta, F. Picard, A. Robinson, U. S. Jhala, J. Apfeld, T. McDonagh, M. Lemieux, M. McBurney, E. J. Easlon, S.-J. Lin, and L. Guarente (2005) Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ?-cells. PLoS Biol 4(2):e31. S. -J. Lin (2006) Molecular Mechanisms of Longevity regulation and calorie restriction. In Nutritional Genomics (Editors: J. Kaput and R. L Rodriguez), pp207-219. John Wiley and Sons, Inc., Hoboken, New Jersey. S. -J. Lin and L. Guarente (2006) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2, e33 D. A. Sinclair, S. -J. Lin and L. Guarente (2006) Life-span extension in yeast. Science 312, 195-197. E. Easlon, F. Tsang, I. Dilova, C. Wang, S-P Lu, C. Skinner and S-J Lin. (2007) The Dihydrolipoamide Acetyltransferase Is A Novel Metabolic Longevity Factor And Is Required For Calorie Restriction Mediated Life Span Extension. J. Biol.Chem. 282:6161-71 I. Dilova, E. Easlon and S.-J. Lin (2007) Calorie Restriction and the Nutrient Sensing Signaling Pathways. Cell Mol Life Sci, 64:752-767. S. -J. Lin and D. Sinclair (2008) Molecular mechanism of aging - insights from yeast. In The Molecular Biology of Aging (Editors: L. Guarente, L. Partridge, and D.Wallace), pp483-516. Cold Spring Harbor Laboratory Press E. Easlon, F. Tsang, C. Skinner, C. Wang and S-J Lin (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction mediated life span extension in yeast. Genes and Development 22:931-944 D. Chen, J. Bruno, E. Easlon, S.-J. Lin, F. Alt and L. Guarente (2008) Tissue-specific Regulation of SIRT1 by Calorie Restriction. Genes and Development 22:1753-7 J. L. Sporty, Md. M. Kabir, K. W. Turteltaub, T. Ognibene, S.-J. Lin, and G. Bench. (2008) Single sample extraction protocol for quantification of NAD and NADH redox states in Saccharomyces cerevisiae. Journal of Separation Science 31:3202-3211 D. Chen, A. D. Steele, G. Hutter, J. Bruno, A. Govindarajan, E. Easlon, S.-J. Lin, A. Aguzzi, S. Lindquist and L. Guarente (2008) Calorie Restriction and SIRT1 Depletion Delay the Onset of Prion Disease. Experimental Gerontology 43:1086-1093 J. Sporty, S. J. Lin, M. Kato, T. Ognibene, B. Stewart, K. Turteltaub, and G. Bench (2009) Quantitation of NAD(+) biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Yeast. (PMID: 19399913) S. P. Lu, M. Kato, and S. J. Lin (2009) Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae. J Biol Chem 284:17110-9. (PMID: 19416965) C. Wang, C. Skinner, E. Easlon and S. -J. Lin (2009) Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increasing Stress Response. Genetics 183:1373-84. (PMID:19805817) S.-P. Lu and S.-J. Lin (2010) Regulation of Yeast Sirtuins by NAD+ Metabolism and Calorie Restriction. Biochim Biophys Acta 1804:1567-1575 (PMC2886167) C. Skinner and S. J. Lin (2010) Effects of calorie restriction on life span of microorganisms. Appl Microbiol Biotechnol. 88: 817-28. (PMC2944023) B. Li, C. Skinner, P. Castello, M. Kato, E. Easlon, L. Xie, T. Li, S. P. Lu, C. Wang, F. Tsang, R. Poyton and S.-J. Lin (2011) Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. Journal of Aging Research 2011:673185. (PMC3092605) Lu S. P. and S. -J. Lin (2011) Phosphate responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae. J. Biol Chem. 286:14271-81. (PMC3077628). C. Skinner and S. -J. Lin (2012) Calorie Restriction, Mitochondria and Longevity in Saccharomyces cerevisiae. In Mitochondrial Signaling in Health and Disease (Oxidative Stress and Disease), pp301-320 (Editors: Sten Orrenius, Lester Packer and Enrique Cadenas) S. -J. Lin and N. Austriaco (2013) Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicans. FEMS Yeast Res. doi: 10.1111/1567-1364.12113.