Kowalczykowski, Stephen - University of California, Davis

研究领域

Biochemical mechanisms of DNA recombination and single-molecule visualization of protein-DNA interactions

近期论文

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Kowalczykowski, S.C. (2015). An overview of the molecular mechanisms of recombinational DNA repair. Cold Spring Harb. Perspect. Biol., 7. 10.1101/cshperspect.a016410 Rad, B., Forget, A.L., Baskin, R.J., and Kowalczykowski, S.C. (2015). Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive DNA unwinding. Proc. Natl. Acad. Sci. U. S. A. dx.doi.org/10.1073/pnas.1518028112 Bell, J.C., Liu, B., and Kowalczykowski, S.C. (2015). Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function. eLife, 4. Wang, A.T., Kim, T., Wagner, J.E., Conti, B.A., Lach, F.P., Huang, A.L., Molina, H., Sanborn, E.M., Zierhut, H., Cornes, B.K., Abhyankar, A., Sougnez, C., Gabriel, S. B., Auerbach, A. D., Kowalczykowski, S. C., and Smogorzewska, A. (2105). A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous recombination. Mol. Cell, 59, 478-490 Morimatsu, K., and Kowalczykowski, S.C. (2014). RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 111, E5133-5142 Liu, B., Baskin, R.J., and Kowalczykowski, S.C. (2013). DNA Unwinding heterogeneity by RecBCD results from static molecules able to equilibrate. Nature, 500, 482–485 Paeschke, K., Bochman, M.L., Garcia, P.D., Cejka, P., Friedman, K.L., Kowalczykowski, S.C., and Zakian, V.A. (2013). Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature, 497, 458-62 Forget, A.L., Dombrowski, C.C., Amitani, I., and Kowalczykowski, S.C. (2013). Exploring protein-DNA interactions in 3D using in situ construction, manipulation, and visualization of individual DNA-dumbbells with optical traps, microfluidics, and fluorescence microscopy. Nature Protoc., 8, 525-538 Bell, J.C., Plank, J.L., Dombrowski, C.C., and Kowalczykowski, S.C. (2012). Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA. Nature, 491, 274-278. Cejka, P., Plank, J.L., Dombrowski, C.C., and Kowalczykowski, S.C. (2012). Decatenation of DNA by the S. cerevisiae Sgs1–Top3–Rmi1 and RPA complex: A mechanism for disentangling chromosomes. Mol. Cell, 47, 886-896. Forget, A.L. and Kowalczykowski, S.C. (2012). Single-molecule imaging of DNA pairing by RecA reveals a 3-dimensional homology search. Nature, 482, 423–427. Nimonkar, A.V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J.L., Wyman, C., Modrich, P., and Kowalczykowski, S.C. (2011). BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA-break repair. Genes & Dev., 25 350-362. Cejka, P., Cannavo, E., Polaczek, P., Masuda-Sasa, T., Pokharel, S., Campbell, J.L., and Kowalczykowski, S.C. (2010). DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature, 467, 112-116 Jensen, R.B., Carreira, A., and Kowalczykowski, S.C. (2010). Purified human BRCA2 stimulates RAD51-mediated recombination. Nature, 467, 678-683