Heyer, Wolf-Dietrich - University of California, Davis

研究领域

Mechanism and regulation of recombinational DNA repair

近期论文

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McVey, M., Khodaverdian, V.Y., Meyer, D., Cerqueira, P.G., and Heyer W.-D. (2016) Eukaryotic DNA polymerases in homologous recombination. Annu. Rev. Genet. In Press. Ganai, R.A., Zhang, X., Heyer, W.-D., and Johansson, E. (2016) Strand displacement synthesis by yeast DNA polymerase ε, Nucleic Acids Res. 2016 Jun 20. pii: gkw556. [Epub ahead of print]. Spies, J., Waizenegger, A., Barton, O., Sürder, M., Wright, W.D., Heyer, W.-D., and Löbrich, M. (2016) Nek1 phosphorylates Rad54 in G2 phase to promote homologous recombination and prevent replication fork instability. Mol. Cell 62, 903-917. Janke, R., Kong, J., Braberg, H., Cantin, G., Yates III, J., Krogan, NJ, and Heyer, W.-D. (2016) Nonsense-mediated decay regulates key components of homologous recombination. Nucleic Acids Res. 44, 5218-5230. Crawley, J.N., Heyer, W.-D., and LaSalle, J.M. (2016) Autism and cancer share risk genes, pathways, and drug-targets. Trends in Genetics 32,139-146. Jenkins, S.S., Mukherjee, S., and Heyer, W.-D. (2016) DNA repair by homologous recombination. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 1, Waltham, MA: Academic Press, pp. 456-467. Kowalczykowski, S.C., Hunter, N., and Heyer, W.-D. (2015) DNA Recombination. Perspectives in Biology, Cold Spring Harbor Press. Meyer, D., Fu, B.X.H., and Heyer, W.-D. (2015) DNA Polymerases delta and lambda cooperate in repairing double-strand breaks by Microhomology Mediated End-joining in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 112, 6907-6916. Heyer W.-D. (2015) Regulation of Recombination and Genome Maintenance. doi:10.1101/cshperspect.a016501 In: DNA Recombination. Perspectives in Biology, Cold Spring Harbor Press. Eds. Kowalczykowski, S.C., Hunter, N., and Heyer, W.-D. Mason, J.M., Dusad, K., Wright, W.D., Grubb, J., Budke, B., Heyer, W.-D., Connell, P.P. Weichselbaum, R.R., and Bishop, D.K. (2015) RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Res. 43, 3180-3196. Fasching, CL., Cejka, P., Kowalczykowski, S.C., and Heyer W.-D. (2015) Top3-Rmi1 dissolve Rad51-mediated D-loops by a topoisomerase-based mechanism. Mol. Cell 57, 595-606. Mukherjee, S., Wright, W.D., Ehmsen, K.T., and Heyer, W.-D. (2014) The Mus81-Mms4 structure-selective endonuclease undergoes nicked junction-induced conformational changes to bend its DNA substrates for cleavage. Nucleic Acids Res. 42, 6511-6522. Wright, W.D. and Heyer, W.-D. (2014) Rad54 is a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D-loop Formation in Homologous Recombination. Mol. Cell 53, 420-432. Sneeden, J.L., Grossi, S.M., Tappin, I., Hurwitz G. and Heyer W.-D. (2013) Reconstitution of recombination-associated DNA synthesis with human proteins. Nucleic Acids Res. 41, 4913-4925. Zinovyev, A., Kuperstein, I., Barillot, E., and Heyer, W.-D. (2013) Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps. PLoS Computat. Biol. 9(4):e1003016. Zhang, X.-P., Janke, R., Kingsley, J., Luo, J., Fasching, C.L., Ehmsen, K.T., and Heyer, W.-D. (2013) A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity. PLoS ONE 8(12): e82184. Munoz-Galvan, S., Tous, C., Gonzalez-Blanco, M., Schwartz, E.K., Ehmsen, K.T., West, S.C., Heyer, W.-D., and Aguilera, A. (2012) Differential roles of Mus81-Mms4, Yen1, and Slx4 in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol. Cell. Biol. 32, 1592-1603. Schwartz, E., Wright, W., Ehmsen, K.T., Evans, D., Stahlberg, H., and Heyer, W.-D. (2012) Mus81-Eme1 functions as single hetero-dimeric endonuclease. Mol. Cell. Biol. 32, 3065-3080. Liu, J. and Heyer, W.-D. (2011) Who’s who in human recombination: BRCA2 and RAD52. Proc. Natl. Acad. Sci. USA 108, 441-442. Liu, J., Renault, L., Veaute, X., Fabre, F., Stahlberg, H., and Heyer, W.-D. (2011) Rad51 paralogs Rad55-Rad57 balance the anti-recombinase function of Srs2 in Rad51 filament formation. Nature 479, 245-248. Liu, J., Doty, T., Gibson, B., and Heyer, W.-D. (2010) Human BRCA2 promotes filament formation RPA-covered ssDNA. Nature Structural & Molecular Biology 17, 1260-1262. Heyer, W.-D., Ehmsen, K.T., and Li, J. (2010) Regulation of homologous recombination in eukaryotes. Annu. Rev. Genetics. 44, 113-139. Li, X., Stith, C.M., Burgers, P.M., and Heyer, W.-D. (2009) PCNA is required for initiating recombination-associated DNA synthesis by DNA polymerase δ. Mol. Cell 36, 704-713.