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研究领域

DNA replication and repair: mapping and characterizing replication-induced fragile sites.

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Barlow, J. H. and Nussenzweig, A. replication initiation and genome instability: a crossroads for DNA and RNA synthesis. Cell Mol Life Sci. 71(23): 4545-59. 2014. Barlow, J.H.*, Faryabi, R. B.*, Callen, E., Wong, N., Malhowski, A., Chen, H.T., Gutierrez-Cruz, G., Sun, H., McKinnon, P., Wright, G., Casellas, R., Robbiani, D.F., Staudt, L., Fernandez-Capetillo, O., and Nussenzweig, A. A novel class of early replicating fragile sites that contribute to genome instability in B cell lymphomas. Cell.152: 620-632, 2013. Bothmer, A., Robbiani, D.F., Di Virgilio, M., Bunting, S.F., Klein, I.A., Feldhahn, N.A., Barlow, J.H., Chen, H., Bosque, D., Callen, E., Nussenzweig, A., and Nussenzweig, M.C. Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1. Molecular Cell. 42(3):319-329, 2011. Barlow, J.H. and Rothstein, R. Timing is everything: cell cycle control of Rad52. Cell Division. 5:7, 2010. Barlow, J.H. and Rothstein, R. The B-type cyclins and Mec1 kinase activity regulate Rad52 recruitment in S phase. EMBO Journal. 28(8):1121-30, 2009. Barlow, J.H., Lisby, M. and Rothstein, R. Differential regulation of the cellular response to DNA double-strand breaks in G1. Molecular Cell. 30:73-85, 2008. Lisby, M., Barlow, J.H., Burgess, R.C., and Rothstein, R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell. 118:699-713, 2004.

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