Nomura, Daniel K. - University of California, Berkeley

个人简介

B.A. University of California, Berkeley (2003) in Molecular and Cell Biology Ph.D. University of California, Berkeley (2008) in Molecular Toxicology Postdoctoral Fellow at The Scripps Research Institute (2011) in Chemical Biology American Cancer Society Postdoctoral Fellow (2009-2010) NIH Pathway to Independence Postdoctoral Fellow (2010-2011) Assistant Professor, University of California, Berkeley (2011-2015) Searle Scholar (2012) Eicosanoid Research Foundation Young Investigator Award (2013) DOD Breakthroughs Award (2014) ACS Research Scholar Award (2014) Associate Professor, University of California, Berkeley (2015-2019) Director, Novartis-Berkeley Center for Proteomics and Chemistry Technologies (2017-current) Co-Founder, Chair of the Scientific Advisory Board for Frontier Medicines (2018-current) Mark Foundation for Cancer Research ASPIRE award (2019) Professor, University of California, Berkeley (2019-current)

研究领域

Chemoproteomics-Enabled Covalent Ligand Discovery against the Undruggable Proteome Expanding the Scope of Targeted Protein Degradation using Chemoproteomic Platforms Discovering New Induced Proximity-Based Therapeutic Modalities

近期论文

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Covalent degrader of the oncogenic transcription factor b-catenin Gowans FA*, Forte N*, Hatcher J, Huang OW, Wang Y, Altamirano Poblano BE, Wertz IE, Nomura DK JACS, 2024, https://doi.org/10.1021/jacs.4c05174. DCAF16-based covalent handle for the rational design of monovalent degraders Lim M*, Do Cong T*, Orr LM, Toriki ES, Kile AC, Lee E, Nomura DK ACS Central Science, 2024, doi: https://doi.org/10.1021/acscentsci.4c00286. Ophiobolin A covalently targets complex IV leading to mitochondrial metabolic collapse in cancer cells. Gowans FA, Thach DQ, Wang Y, Altamirano Poblano BE, Dovala D, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK* ACS Chemical Biology, doi: 10.1021/acschembio.4c00064. PMID 38739449. FATP5 is indispensable for the growth of intrahepatic cholangiocarcinoma Shihadih D, Wang X, Zushin P-JH, Khodakivskyi P, Park HM, Tso E, Shiblak J, Misic A, Louie SM, Ward C, Hellerstein M, Nomura DK, Goun E, Urigo F, Calvisi DF, Chen X, Stahl A Molecular Cancer Research, 2024, doi:10.1158/1541-7786.MCR-23-0389. PMID 38358323 Exploiting the Cullin E3 ligase adaptor protein SKP1 for targeted protein degradation Hong SH*, Divakaran A*, Osa A, Huang OW, Wertz IE, Nomura DK ACS Chemical Biology, 2024, http://doi.org/10.1021/acschembio.3c00642. PMID 37904950. Targeted protein degradation through recruitment of the CUL4 complex adaptor protein DDB1 Meyers M, Cismoski S, Panidapu A, Chie-Leon B, Nomura DK ACS Chemical Biology, 2024, doi: 10.1021/acschembio.3c00487. PMID 38192078 Covalent 14-3-3 molecular glues and heterobifunctional molecules against nuclear transcription factors and regulators Shao Q, Duong TN, Park I, Nomura DK BioRxiv, 2023, doi: https://doi.org/10.1101/2023.11.06.565850. A cellular platform for production of C4 monomers Davis MA, Yu VY, Fu B, Wen M, Koleski EJ, Silverman J, Berdan CA, Nomura DK, Chang MCY Chemical Science, 2023, 14, 11718-11726. PMID 37920356 Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism Pham VN, Bruemmer KJ, Toh JDW, Ge EJ, Tenney L, Ward CC, Fingler FA, Millington CL, Garcia-Prieto CA, Pulos-Holmes MC, Ingolia NT, Pontel LB, Esteller M, Patel KJ, Nomura DK, Chang CJ Science, 2023, 382, doi: 10.1126/science.abp9201. Mercapto-pyrmidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N RSC Advances, 2023, 13, 17667-17677. PMID 37312993 Covalent targeting of glutamate cysteine ligase to inhibit glutathione synthesis Zhang L, Tang M, Tao X, Shao Q, Thomas V, Shimizu S, Kasano M, Ishikawa Y, Inukai T, Nomura DK Chembiochem, 2023, doi: 10.1002/cbic.202300371. PMID 37756477 N-acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics Koo T-Y, Lai H, Nomura DK, Chung CY-K. Nature Communications, 2023, https://doi.org/10.1038/s41467-023-39268-w. A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication Han H, Gracia AV, Roise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N. RSC Advances, 2023, 13, 10636-10641. PMID 37025664 Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging Benjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, Chung M, Arjona M, Nutter CW, Tan JH, Krishnan AK, Dulay H, Louie SM, de Morree A, Nomura DK, Rando TA Cell Metabolism, 2023, 35, 472-486. PMID 36854304 Rational Chemical Design of Molecular Glue Degraders Toriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song J-G, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK ACS Central Science, 2023, 9, 915-926. (* co-first authorship) Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-kB King EA, Cho Y, Hsu, NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK Cell Chemical Biology, 2023, 30, 394-402. PMID 36898369 Targeted Protein Degradation through E2 Recruitment Forte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK ACS Chemical Biology, 2023, https://doi.org/10.1021/acschembio.3c00040. PMID 36940189 Ligandability of E3 Ligases for Targeted Protein Degradation Applications Belcher B, Ward CC, Nomura DK Biochemistry, 2023, 62, 588-600. PMID 34473924 Advances in covalent drug discovery Boike L*, Henning NJ*, Nomura DK Nature Reviews Drug Discovery, 2022, 21, 881-898. PMID 36008483 Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization Henning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK Discovery of potent pyrazoline-based covalent SARS-CoV-2 main protease inhibitors Moon P*, Zammt CM*, Shao Q*, Dovala D*, Boike L*, Henning NJ*, Knapp M*, Spradlin JN*, Ward CC*, Wolleb H*, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD#, Nomura DK# Chembiochem, 2023, https://doi.org/10.1002/cbic.202300116. (*co-first authors; #co-corresponding authors) Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3 Belcher BP, Machicao PA, Tong B, Ho E, Friedli J, So B, Bui H, Isobe Y, Maimone TJ#, Nomura DK# Chembiochem, 2023, doi: 10.1002/cbic.202300111. PMID 36964942 (#co-corresponding authors). (#co-corresponding authors) Ligandability of E3 Ligases for Targeted Protein Degradation Applications Belcher B, Ward CC, Nomura DK Biochemistry, 2023, 62, 588-600. PMID 34473924 Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim C-Y, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R Science, 2022, 377, 1290-1298. PMID 36007018 Advances in covalent drug discovery Boike L*, Henning NJ*, Nomura DK Nature Reviews Drug Discovery, 2022, 21, 881-898. PMID 36008483 (*co-first authors) Tyrosinase-Mediated Synthesis of Nanobody-Cell Conjugates Maza JC, Garcia-Almedina DM, Boike LE, Hamlish NX, Nomura DK, Francis MB ACS Central Science, 2022, 8, 955-962. PMID 35912347 Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling Benjamin DI, Both P, Benjamin JS, Nutter CW, Tan JH, Kang J, Machado LA, Klein JDD, de Morree A, Kim S, Liu L, Dulay H, Feraboli L, Louie SM, Nomura DK, Rando TA Cell Metabolism 2022, 34, 1-17. PMID 35584694 Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design Page ACS, Scholz SO, Keenan KN, Spradlin JN, Belcher BP, Brittain SM, Tallarico JA, McKenna JM, Schirle M, Nomura DK*, Toste FD*2022, Chemical Science 13, 3851-3856. PMID 35432890 Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization Henning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK Nature Chemical Biology, 2022, 18, 412-421. PMID 35210618 Discovery of a covalent FEM1B recruiter for targeted protein degradation applications Henning NJ*, Manford AG*, Spradlin JN, Brittain SM, Zhang E, McKenna JM, Tallarico JA, Schirle M, Rape M#, Nomura DK# Discovery of a covalent FEM1B recruiter for targeted protein degradation applications. JACS, 2022, 144, 701-708. PMID 34994556 Reimagining Druggability using Chemoproteomic Platforms Spradlin JN, Zhang E, Nomura DK Accounts of Chemical Research, 2021, 54, 1801-1813. PMID 33733731 Chemoproteomics-enabled ligand discovery of covalent RNF114-based degraders that mimic natural product function Luo M*, Spradlin JN*, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#.Cell Chemical Biology, 2021, 28, 559-566. PMID 33513350 Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC Boike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.Cell Chemical Biology, 2021, 28, 4-13. PMID 32966806 Advances and opportunities in targeted protein degradation Nomura DK, Dey M Cell Chemical Biology 15, 887-888. PMID 34270936 De novo design of SARS-CoV-2 Main Protease Inhibitors Trauner D, Fischer C, Nynke V, Peitsinis Z, Ruhmann P, Yang C, Spradlin J, Dovala D, Nomura D, Zhang Y 2021, Synlett, 33, 458-463. PMID 35282568 CYP27A1 dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism Cho H, Shen Q, Zhang LH, Okumura M, Kawakami A, Ambrose J, Sigoillot F, Miller HR, Gleim S, Cobos-Correa A, Wang Y, Piechon P, Roma G, Eggiman F, Moore C, Aspesi Jr. P, Mapa FA, Burks H, Ross NT, Krastel P, Hild M, Maimone TJ, Fisher DE, Nomura DK, Tallarico JT, Canham SM, Jenkins JL, Forrester WC Cell Chemical Biology, 2021, 28, 1407-1419. PMID 33794192 Mitohormesis reprograms macrophage metabolism to enforce tolerance Timblin GA, Tharp KM, Ford B, Winchenster JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, ten Hoeve J, Nomura DK, Stahl A, Saijo K Nature Metabolism, 2021, 3, 618-635. PMID 34031590 Oncogene regulated release of extracellular vesicles Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohn RA, Avsaroglu B, L’Etoile ND, Perera RM, Nomura DK, Goga A Developmental Cell, 2021, 56, 1989-2006. PMID 34118203 Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2 Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze Gahmen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. ACS Infectious Diseases, 2021, 7, 2337-2351. PMID 34129317 Adhesion-mediated mechanosignaling forces mitohormesis Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saiko K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. Cell Metabolism, 2021, 33, 1322-1341. PMID 34019840 4beta-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor. Moldavski O, Zushin P-JH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey SF, Nomura DK, Stahl A, Weiss EJ, Zoncu R Journal of Lipid Research, 2021, 62, 100051. PMID 33631213 Lipidome-based targeting of STAT3-driven breast cancer cells using poly-L-glutamic acid-coated layer-by-layer nanoparticles Tosic I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Grossman EA, Pal S, Richardson D, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA.Molecular Cancer Therapeutics, 2021, 20, 726-738. PMID 33536189