Schaffer, David V. - University of California, Berkeley

个人简介

Professor. B.S. Stanford University (1993); Ph.D. Massachusetts Institute of Technology (1998). Distinguished Lindsey Lectureship, Texas A&M (2012); Eagleson Award, American Biological Safety Association (2012); Fellow, American Institute for Medical and Biological Engineers (2010); Robert W. Vaughan Lectureship, California Institute of Technology (2008); American Chemical Society BIOT Division Young Investigator Award (2006); Van Ness Award Lecturer, Rennselaer Polytechnic Institute (2006); Departmental Citation for Excellence in Teaching (2003); Technology Review Magazine "Top 100 Innovator Under 35" (2002); American Institute of Chemical Engineers (NorCal) Excellence in Teaching Award (2002); Family Faculty Award (2001);National Science Foundation CAREER Award (2001); Office of Naval Research Young Investigator (2001); The Biomedical Engineering Society Rita Shaffer Young Investigator Award (2000); U.C. Berkeley Wills Neuroscience Institute Member (1999); Regents' Junior Faculty Award (1999).

研究领域

Biomedical Engineering We have developed a research program that employs molecular and cellular engineering approaches to attempt to investigate biomedical problems. In particular, our lab is interested in the related areas of gene therapy and stem cell biology, with applications to therapies for diseases of the nervous system.

近期论文

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Tervo, D.G.R., B-Y. Hwang, S. Viswanathan, T. Gaj, M. Lavzin, K.D. Ritola, S. Lindo, S. Michael, E.P. Kuleshova, D. Ojala, C-C. Huang, C.R. Gerfen, J. Schiller, J.T. Dudman, A.W. Hantman, L.L. Looger, D.V. Schaffer (co-corresponding author), and A.Y. Karpova (2016) “A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.” Neuron , 92:372-382 (PMID 27720486). View PDF Chen, S. Y.S. Na, M.E. Todhunger, S. Hsiao, A.W. Bremer, O.J. Scheideler, P.R. Bomdica, M.M. Haharbiz, Z.J. Gartner, D.V. Schaffer (2016) “Interrogating Stem Cell Fate Decisions with High-throughput Arrays of Cellular Communities.” Nature Communications. Jan 12; 7:10309 (PMID 26754526). View PDF Bugaj, L.J., D. P. Spelke, C.K. Mesuda, M. Varedi, R.S. Kane, and D.V. Schaffer (2015) “Regulation of Endogenous Transmembrane Receptors Through Optogenetic Cry2 Clustering.” Nature Communications, 6:6898 (PMID 25902152). View PDF Kotterman, M.A. and D.V. Schaffer (2014) “Engineering Adeno-Associated Viruses for Clinical Gene Therapy.” Nature Reviews Genetics, 15:445-451 (PMID 24840552). View PDF Hughes, A.J., D.P. Spelke, Z. Xu, C-C. Kang, D.V. Schaffer (co-corresponding author), and A.E. Herr (2014) “Single-cell Western Blotting.” Nature Methods, 11(7):749-55 (PMID 24880876). View PDF Shapiro, M., P. Goodwill, A. Neogy, M. Yin, F. Foster, D.V. Schaffer, and S. Conolly (2014) “Biogenic Gas Nanostructures as Ultrasonic Molecular Reporters.” Nature Nanotechnology, 9(4):311-6 (PMID: 24633522). View PDF Shapiro, M.G., R.M. Ramirez, L.J. Sperling, G. Sun, A. Pines, D.V. Schaffer, and V.S. Bajaj (2014) “Genetically Encoded Reporters for Hyperpolarized Xenon.” Nature Chemistry, 6:629-634 (PMID 24950334). View PDF Lei, Y. and D.V. Schaffer (2013) “A Fully Defined and Scalable 3D Culture System for Human Pluripotent Stem Cell Expansion and Differentiation.” Proceedings of the National Academy of Sciences USA, 110:E5039-5048 (PMID 24248365). View PDF Conway, A., T. Vazin, D.P. Spelke, N.A. Rode, K.E. Healy, R.S. Kane, and D.V. Schaffer (2013) “Multivalent Ligands to Control Stem Cell Behaviour in Vitro and in Vivo.” Nature Nanotechnology, 8:831-838 (PMID 24141540). View PDF Downing, T.L., J. Soto, C. Morez, T. Houssin, A. Fritz, F. Yuan, J. Chu, S. Patel, D.V. Schaffer, and S. Li (2013) “Biophysical Regulation of Epigenetic State and Cell Reprogramming.” Nature Materials, 12:1154-1162 (PMID 24141451). View PDF Dalkara, D., L.C. Byrne, R.R. Klimczak, M. Visel, L. Yin, W.H. Merigan, J.G. Flannery, and D.V. Schaffer (2013) "In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer-Retinal Gene Delivery from the Vitreous." Science Translational Medicine, 5:189ra76 (PMID 23761039). View PDF Bugaj, L.J, A.T Choksi, C.K. Mesuda, R.S. Kane, and D.V. Schaffer (2013) "Optogenetic Protein Clustering and Signaling Activation in Mammalian Cells." Nature Methods, 10:249-252. View PDF Ashton, R.S., A. Conway, C. Pangarkar, J. Bergen, K-I. Lim, P. Shah, M. Bissell, and D.V. Schaffer (2012) "Astrocytes Regulate Adult Hippocampal Neurogenesis Through Ephrin-B Signaling." Nature Neuroscience,15:1399-1406 (PMID: 22983209). View PDF Dickinson, B.C., J. Peltier, D. Stone, D.V. Schaffer (co-corresponding author), and C.J Chang (2011) "Nox2 Redox Signaling Maintains Essential Cell Populations in the Brain." Nature Chemical Biology, 7:106-112 (PMID 21186346). View PDF Lim, K-I., R.R. Klimczak, J.H. Yu, and D.V. Schaffer (2010) "Specific Insertions of Zinc Finger Domains into Gag-Pol Yields Engineered Retroviral Vectors with Selective Integration Properties." Proceedings of the National Academy of Sciences USA, 107:12475-12480 (PMID 20616052). View PDF Excoffon, K.J., J.T. Koerber, D.D. Dickey, M. Murtha, S. Keshavjee, B.K. Kaspar, J. Zabner, and D.V. Schaffer (2009) "Directed Evolution of Adeno-Associated Virus to an Infectious Respiratory Virus." Proceedings of the National Academy of Sciences USA, 106:3865-3870 (PMID 19237554). View PDF Koerber, J.T., N. Maheshri, B.K. Kaspar, and D.V. Schaffer (2006) "Construction of Diverse Adeno-Associated Viral Libraries for Directed Evolution of Enhanced Gene Delivery Vehicles." Nature Protocols, 1:701-706. View PDF Maheshri, N., J.T. Koerber, B. Kaspar, and D.V. Schaffer (2006) "Directed Evolution of Adeno-Associated Virus Yields Enhanced Gene Delivery Vectors." Nature Biotechnology, 24:198-204. View PDF Weinberger, L.S., J.C. Burnett, J.E. Toettcher, A.P. Arkin, and D.V. Schaffer (2005) "Stochastic Gene Expression in a Lentiviral Feedback Loop: HIV-1 Tat Expression Drives Phenotypic Diversity." Cell, 122:169-182. View PDF Maheshri, N. and D.V. Schaffer (2003) "Computational and Experimental Analysis of DNA Shuffling." Proceedings of the National Academy of Sciences USA, 100:3071-3076. View PDF Lai, K, B.K. Kaspar, F.H. Gage, and D.V. Schaffer (2003) "Sonic Hedgehog Regulates Adult Neural Progenitor Proliferation in Vitro and in Vivo." Nature Neuroscience, 6(1):21-27. View PDF