Muller, Susan J. - University of California, Berkeley - Chemical & Biomolecular Engineering

个人简介

Professor; Faculty Scientist, Lawrence Berkeley National Laboratory. Ph.D., Massachusetts Institute of Technology

研究领域

Rheology and fluid mechanics of complex fluids Flow of Biological Fluids in Micro-Fluidic Devices: Microfabrication processes enable the design and manufacture of systems on the microscale. Such microsystems are capable of processing and analyzing biochemical samples and offer multiple advantages compared to conventional systems and protocols. Scaling down the system and increasing the number of samples processed per chip would result in heightened efficiency and reduced cost. The realization of these benefits, however, requires understanding fundamental physical principles on this scale. Genetic Engineering of Protein Polymers: The goal of this research is the development of a simple but widely applicable method for making novel protein polymers and evaluating their structure-property relationships. A series of DNA "monomers," encoding 12-20 amino acids, were designed to construct amphipathic multi-block copolymers consisting of a hydrophilic and a hydrophobic amino acid. Depending on the choice of DNA monomers and the relative mole fractions used in constructing the gene, the average composition, amino acid segment length, and disorder of the sequence can be varied. These parameters have proven to be important design variables in controlling polymer mechanical properties, thermal transitions, chain conformations, and interactions with surfaces and solvents. Finite Element Modeling of Bubbles in Yield Stress Fluids and Taylor-Couette Instabilities

近期论文

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Flow of viscoelastic fluids around a sharp microfluidic bend: Role of wormlike micellar structure, M.Y. Hwang, H. Mohammadigoushki, S.J. Muller, Physical Review Fluids, 2 (2017), 043303. Optimization and application of dry film photoresist for rapid fabrication of high-aspect-ratio microfluidic devices, F. Khalkhal, K.H. Chaney, S.J. Muller, Microfluidics and Nanofluidics, 20 (2016), 153. Measuring cell viscoelastic properties using a microfluidic extensional flow device, L. Guillou, J.B. Dahl, J.-M. G. Lin, A.I. Barakat, J. Husson, S.J. Muller, and S. Kumar, Biophysical Journal, 111 (2016); 2039-2050. Sedimentation of a sphere in wormlike micellar fluids, H. Mohammadigoushki and S.J. Muller, Journal of Rheology, 60 (2016), 587; DOI: 10.1122/1.4948800. Experimental observation of the asymmetric instability of intermediate-reduced-volume vesicles in extensional flow, J.B. Dahl, V. Narsimhan, B. Gouveia, S. Kumar, E.S.G. Shaqfeh, and S.J. Muller, Soft Matter, (2016); DOI: 10.1039/C5SM03004H. Settling of a sphere in wormlike micellar fluids, H. Mohammadigoushki and S.J. Muller, Proceedings of the XVIIth International Congress on Rheology, Kyoto, Japan, August 2016. Optimizing a microfluidic device to produce double emulsions, R. Hidema, F. Khalkhal, and S.J. Muller, Proceedings of the XVIIth International Congress on Rheology, Kyoto, Japan, August 2016. A flow visualization and superposition rheology study of shear-banding wormlike micelle solutions, H. Mohammadigoushki and S.J. Muller, Soft Matter, (2015); DOI: 10.1039/c5sm02266e. Microfluidic strategies for understanding the mechanics of cells and cell-mimetic systems, J.B.Dahl, J.-M. G. Lin, S.J. Muller, and S. Kumar, Annual Review of Chemical and Biomolecular Engineering, 6 (2015), 293-317. Flow of DNA solutions in a microfluidic gradual contraction, S. Gulati, S. Muller, and D. Liepmann, Biomicrofludics, 9 (2015), 054102. Quantifying elastic vortex growth of DNA solutions in planar micro-bends, S. Gulati, S.J. Muller, and D. Liepmann, Proceedings of the ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels, ICNMM2014-21428, (2014). Effects of moderate elasticity on the stability of co- and counter-rotating Taylor-Couette flows, C.S. Dutcher and S.J. Muller, Journal of Rheology, 57 (2013), 791-812. Polymer-monovalent salt-induced DNA compaction studied via single-molecule microfluidic trapping, W. Xu and S.J. Muller, Lab on a Chip, 12 (2012), 647-651. Effects of weak elasticity on the stability of high Reynolds number co- and counter-rotating Taylor-Couette flows, C.S. Dutcher and S.J. Muller, Journal of Rheology, 55 (2011), 1271-1295. Labeling DNA for Single-Molecule Experiments: Methods of Labeling Internal Specific Sequences on Double-Stranded DNA, H. Zohar and S.J. Muller, Nanoscale, 3 (2011), 3027-3039. Exploring both sequence detection and site-specific restriction endonuclease cleavage kinetics via single-molecule microfluidic trapping, W. Xu and S.J. Muller, Lab on a Chip, 11 (2011) 435-442. Peptide Nucleic Acids as Tools for Single-Molecule Sequence Detection and Manipulation, H. Zohar, C. Hetherington, C. Bustamante, S. Muller, Nano Letters, 10 (2010) 4697-4701. Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma, S. Sidhu, S. Yuan, A. Innes, S. Kerr, P. Woodruff, L. Hou, M. Solon, S. Muller, J. Fahy, Proc. Natl. Acad. Sci. USA, 107 (2010) 14170-14175. Single-molecule sequence detection via microfluidic planar extensional flow at a stagnation point, R. Dylla-Spears, J.E. Townsend, L. Jen-Jacobson, L.L. Sohn, and S.J. Muller, Lab on a Chip, 10 (2010) 1543-1549. Generation of Monodisperse Silk Microspheres Prepared with Microfluidics, D.N. Breslauer, S.J. Muller and L.P. Lee, Biomacromolecules, 11 (2010) 643-647. Elastic secondary flows in sharp 90 degree micro-bends: a comparison of PEO and DNA solutions, S. Gulati, C.S. Dutcher, D. Liepmann, and S.J. Muller, J. Rheol., 54 (2010) 375-392. The Effects of Drag Reducing Polymers on Flow Stability: Insights from the Taylor-Couette Problem, C.S. Dutcher and S.J. Muller, Korea-Australia Rheology Journal, 21 (2009) 213-223. Fluorescent marker for direct detection of specific dsDNA sequences, R. Dylla-Spears, J. E. Townsend, L. L. Sohn, L. Jen-Jacobson, and S. J. Muller, Analytical Chemistry, 81 (2009) 10049-10054. Spatio-temporal mode dynamics and higher order transitions in high aspect ratio Newtonian Taylor-Couette flows, C.S. Dutcher and S.J. Muller, J. Fluid Mechanics, 641 (2009) 85-113. Simulation of Flow in the Silk Gland, D.N. Breslauer, L.P. Lee, and S.J. Muller, Biomacromolecules, 10 (2009) 49-57.