Kumar, Sanjay - University of California, Berkeley - Chemical & Biomolecular Engineering

个人简介

Sanjay Kumar earned a B.S. in Chemical Engineering (1996) from the University of Minnesota, and both an M.D. (2003) and Ph.D. in Molecular Biophysics (2003) from Johns Hopkins University as a fellow of the NIH Medical Scientist Training Program. From 2003-2005, he served as an NIH research fellow at Children's Hospital Boston and Harvard Medical School. He was appointed Assistant Professor of Bioengineering at UC Berkeley in 2005 and eventually promoted to Full Professor in 2014. He has been the Associate Chair of Bioengineering since 2015 and previously directed the UC Berkeley - UCSF Master of Translational Medicine and Bioengineering PhD Programs. He is also a Faculty Scientist in the Biological Systems & Engineering Division of Lawrence Berkeley National Laboratory. Dr. Kumar and his research group have been fortunate to receive a number of honors, including the Presidential Early Career Award for Scientists and Engineers (PECASE), The NIH Director's New Innovator Award, The Arnold and Mabel Beckman Young Investigator Award, the NSF CAREER Award, the Stem Cells Young Investigator Award, and the Hellman Family Faculty Fund Award. He is an elected Fellow of the AIMBE.

研究领域

Biomaterials, Molecular and Cellular Bioengineering, Stem Cells, Cancer Biology, Translational Medicine My research team and I seek to understand and control biophysical communication between cells and their surroundings. In addition to investigating fundamental aspects of this problem, we are especially interested in understanding the role played by cellular mechanobiological signaling in tumor and stem cell biology in the central nervous system. Two important recent directions for our work have been to leverage the tools of synthetic biology to "rewire" cell-environment communication by placing mechanobiological signaling systems under the control of one or more small-molecule inducers and repressors, and to synthesize or fabricate new tissue-mimetic culture platforms for biophysical studies and molecular screening. Finally, we are very interested in developing new materials based on cellular structural networks that may have broader applications in biotechnology and soft materials science.

近期论文

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J. Chen and S. Kumar (2017). Biophysical Regulation of Cancer Stem/Initiating Cells: Implications for Disease Mechanisms and Translation. Current Opinion in Biomedical Engineering (in press). S. Rammensee,* M. S. Kang,* K. Georgiou, S. Kumar,** and D. V. Schaffer** (2017). Dynamics of Mechanosensitive Neural Stem Cell Differentiation. Stem Cells 35: 497-506 (PDF) [*equal contribution; **co-corresponding]. E. Kassianidou, C. A. Brand, U. S. Schwarz, and S. Kumar (2017). Geometry and network connectivity govern stress fiber mechanics. Proceedings of the National Academy of Sciences (PNAS) 114: 2622-2627 (PDF). L. Guillou,* J. B. Dahl,* J. M. Lin,* A. I. Barakat, J. Husson, S. J. Muller, and S. Kumar (2016). Measuring cell viscoelastic properties using a microfluidic extensional flow device. Biophysical Journal 111: 2039-2050 (PDF) [*equal contribution]. S. Lee and S. Kumar (2016). Actomyosin stress fiber mechanosensing in 2D and 3D. F1000 Faculty Reviews 5: 2261 (PDF). J. P. Lee, E. Kassianidou, J. I. MacDonald, M. B. Francis, and S. Kumar (2016). N-terminal Specific Conjugation of Extracellular Matrix Proteins to 2-Pyridinecarboxaldehyde Functionalized Polyacrylamide Hydrogels. Biomaterials 102: 268-276 (PDF). M. Bhagawati, M. G. Rubashkin, J. P. Lee, B. Ananthanarayanan, V. M. Weaver, and S. Kumar (2016). Site-specific modulation of charge controls the structure and stimulus-responsiveness of intrinsically disordered peptide brushes. Langmuir 32: 5990-5996 (PDF). T. Luque*, M. S. Kang*, D. V. Schaffer, and S. Kumar (2016). Microelastic mapping of the rat dentate gyrus. Royal Society Open Science 3: 150702 (PDF) [*equal contribution]. J. B. Dahl, V. Narasimhan, B. Gouvela, S. Kumar, E. S. G. Shaqfeh, and S. J. Muller (2016). Experimental observation of the asymmetric instability of intermediate-reduced-volume vesicles in extensional flow. Soft Matter 12: 3787-3796 (PDF). J. H. Hughes and S. Kumar (2016). Synthetic mechanobiology: Engineering cellular force generation and signaling. Current Opinion in Biotechnology 40: 82-89 (PDF). R. A. Gould, H. C. Yalcin, J. L. MacKay, K. Sauls, R. Norris, S. Kumar, and J. T. Butcher (2016). Cyclic mechanical loading is essential for Rac-1-mediated elongation and remodeling of the embryonic mitral valve. Current Biology 26: 27-37 (PDF). A. D. Rape, M. Zibinsky, N. Murthy, and S. Kumar (2015). A synthetic hydrogel for the high-throughput study of cell–ECM interactions. Nature Communications 6: 8129 (PDF) J. Santiago-Ortiz, D. S. Ojala, O. Westesson, J. R. Weinstein, S. Y. Wong, S. Kumar, I. Holmes, and D. V. Schaffer (2015). AAV ancestral reconstruction library enables selection of broadly infectious viral variants. Gene Therapy 22: 934-946 (PDF). A. D. Rape and S. Kumar (2015). Engineering strategies to recapitulate the tumor microenvironment. Book chapter for Cells, Forces, and the Microenvironment, CRC Press-Taylor and Francis Group, LLC (C. M. Cuerrier and A. E. Pelling, eds.) (PDF). C.-W. Chang and S. Kumar (2015). Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics. Scientific Reports 5: 13736 (PDF). E. Kassianidou and S. Kumar (2015). A biomechanical perspective on stress fiber structure and function. BBA Molecular Cell Research 1853: 3065-3074 (PDF) J. B. Dahl*, J.-M. Lin*, S. J. Muller, and S. Kumar (2015). Microfluidic strategies for understanding the mechanics of cells and cell-mimetic systems. Annual Review of Chemical and Biomolecular Engineering 6: 293-317 (PDF) [*equal contribution]. S. Y. Wong, T. A. Ulrich, L. P. Deleyrolle, J. L. MacKay, J.-M. Lin, R. T. Martuscello, M. A. Jundi, B. A. Reynolds, and S. Kumar (2015). Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tumor invasion. Cancer Research 75: 1113-1122 (PDF). M. Bhagawati and S. Kumar (2014). Biofunctionalization of hydrogels for engineering the cellular microenvironment. Book chapter for Micro- and Nanoengineering the Cell Surface, Elsevier (J .M. Karp and W. Zhao, eds.) (PDF). S. Y. Wong and S. Kumar (2014). Matrix Regulation of Tumor-Initiating Cells. Book chapter for Mechanotransduction, Elsevier. Indexed as Progress in Molecular Biology and Translational Science 126: 243-256 (PDF). N. Srinivasan, M. Bhagawati, B. Ananthanarayanan, and S. Kumar (2014). Stimuli-sensitive intrinsically disordered protein brushes. Nature Communications 5: 5145 DOI 10.1038/ncomms6145 (PDF) (F1000 Review). Y. Qiu, A. C. Brown, D. R. Myers, Y. Sakurai, R. G. Mannino, R. Tran, B. Ahn, E. T. Hardy, M. F. Kee, S. Kumar, G. Bao, T. H. Barker, and W. A. Lam (2014). Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proceedings of the National Academy of Sciences (PNAS) 111: 14430 – 14435 (PDF). S. Kumar (2014). Cellular mechanotransduction: Stiffness does matter. Nature Materials 13: 918-920 (PDF). C. C. Kang, J. M. Lin, Z. Xu, S. Kumar, and A. E. Herr (2014). Single-cell western blotting after whole-cell imaging to assess cancer chemotherapeutic response. Analytical Chemistry 86: 10429-10436 (PDF) A. D. Rape, B. Ananthanarayanan, and S. Kumar (2014). Engineering Strategies to Mimic the Glioblastoma Microenvironment. Advanced Drug Delivery Reviews 79-80: 172-183 (PDF).