个人简介

1999 B.A. Structural Biochemistry - Université Paul Sabatier (Toulouse, France) 2000 M.S. Biology & Biotechnology - INSA (Toulouse, France) 2006 Ph.D. Chemistry & Biochemistry - University of Delaware 2011 Postdoctoral Associate - Yale University

研究领域

Biochemistry, membrane protein biophysics and drug delivery

The research conducted in our group is in the field of membrane biophysics and is organized around 2 areas: (1) Developing novel strategies to specifically target and deliver small therapeutic molecules and peptides to cancer cells and (ii) understanding how membrane receptors communicate signals across cell membranes. More specifically, we are interesting on the role of the transmembrane and juxtamembrane domains in this process. As such, our work is applied, fundamental, highly interdisciplinary, and draws upon areas such as peptide and protein chemistry, biophysics, molecular and structural biology, and biochemistry. For example, ongoing projects are aimed at targeting and delivering potent cytotoxics and antimicrobial peptides to cancer cells using the pH(Low) Insertion Peptide, and at identifying the structural requirements for the dimerization of an understudied, but essential family of membrane receptors, the receptor protein-tyrosine phosphatases (RPTPs).

近期论文

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Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VTK, Engelman DM and Engelward B. (2013) Peptide targeting and imaging of damaged lung tissue un influenza-infected mouse. Future Microbiology 8, 257-269 Thévenin D and Lazarova T. (2011) Book Chapter: Measuring transmembrane helix interactions by Förster resonance energy transfer. Methods in Molecular Biology (Eds.Vaidehi N and Klein-Seetharaman J). Matthews EE, Thévenin D*, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, and Engelman, DM. (2011) Transmembrane helix dimerization and rotation in signaling by thethrombopoietin receptor. FASEB Journal Thévenin D, An M and Engelman, DM. (2009) pHLIP-mediated translocation of membraneimpermeable molecules into cells. Chemistry & Biology 16(7) 754-62. Thévenin D, Lazarova T (2008) Stable interactions between transmembrane domains of the adenosine A2A receptor. Protein Science 17, 1188-1199 Thévenin D, Lazarova T, Roberts M and Robinson CR (2005) Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Science 14(8) 2177-2186 Thévenin D, Lazarova T, Roberts M and Robinson CR (2005) Identifying interactions between transmembrane helices from the adenosine A2A receptor. Biochemistry 44, 16239-16245.