个人简介

Bob Flowers was born in Easton, Pennsylvania in 1964. He received his B.S. in chemistry from East Stroudsburg University of Pennsylvania in 1986. After taking timeoff from school, he was admitted to Lehigh University in 1987 and received his Ph.D. inchemistry in 1991 working with John Larsen on single electron transfer reactions in coal. After graduating from Lehigh, he moved to Duke University as a postdoctoral researchassociate with Professor Ned Arnett where he worked on several projects

研究领域

Lanthanide chemistry, single electron transfer, catalysis, and protein refolding.

The research in the Flowers group focuses on the mechanistic analysis of various metal-mediated reactions that go through single-electron transfer. The mechanistic studies employ a variety of techniques to investigate reaction kinetics, a few of which include stopped-flow spectrophotometry, reactIR, and NMR spectroscopy. This physical organic approach provides new information about new and old organometallic reactions utilized in chemical synthesis.

近期论文

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Shen M, Tu Y, Xie G, Niu Q, Mao H, Xie T, Flowers RA, Lv X, Wang X. 2015. Allylsamarium Bromide-Mediated Cascade Cyclization of Homoallylic Esters. Synthesis of 2-(2-Hydroxyalkyl)cyclopropanols and 2-(2-Hydroxyethyl)bicyclo[2.1.1]hexan-1-ols. J. Org. Chem.. 80(1):9. Chciuk TV, Boland BP, Flowers, II RA. 2015. Mechanistic study of the samarium diiodide—N,N-dimethyl-2-aminoethanol reducing system. Tetrahedron Letters. Gansauer A, von Laufenberg D, Kube C, Dahmen T, Michelmann A, Behlendorf M, Sure R, Seddiqzai M, Grimme S, Sadasivam DV et al.. 2015. Mechanistic Study of the Titanocene(III)-Catalyzed Radical Arylation of Epoxides. Chemistry - A European Journal. 21(1):9. Devery, III JJ, Douglas JJ, Nguyen JD, Cole KP, Flowers, II RA, Stephenson CRJ. 2014. Ligand functionalization as a deactivation pathway in a fac-Ir(ppy)3-mediated radical addition. Chemical Science. 2015(1):537-541. Chciuk TV, Hilmersson G, Flowers, II RA. 2014. Solvent-Dependent Substrate Reduction by {Sm[N(SiMe3)2]2(THF)2}. An Alternative Approach for Accelerating the Rate of Substrate Reduction by Sm(II). Journal of Organic Chemistry. 79(20):9443. Gansauer A, Flowers, II RA, Sadasivam D, Kube C, Daasbjerg K, Sure R, Grimme S, Fianu G. 2014. Substituent Effects and Supramolecular Interactions of Titanocene(III) Chloride: Implications for Catalysis in Single Electron Steps. Journal of the American Chemical Society. 136(4):1671. Casey BM, Sadasivam DV, Flowers, II RA. 2013. Mechanistic studies on the CAN-​mediated intramolecular cyclization of δ-​aryl-​β-​dicarbonyl compounds. Beilstein Journal of Organic Chemistry. 9:8. Sadasivam DV, Choquette KA, Flowers, II RA. 2013. Preparation and Use of Samarium Diiodide (SmI2) in Organic Synthesis: The Mechanistic Role of HMPA and Ni(II) Salts in the Samarium Barbier Reaction. Journal of Visual Chemistry. Szostak M, Spain M, Choquette KA, Flowers RA, Procter DJ. 2013. Substrate-​Directable Electron Transfer Reactions. Dramatic Rate Enhancement in the Chemoselective Reduction of Cyclic Esters Using SmI2-​H2O: Mechanism, Scope, and Synthetic Utility. Journal of the American Chemical Society. 135(42):3. Patel NR. 2013. Uncovering the Mechanism of the Ag(I)​/Persulfate-​Catalyzed Cross-​Coupling Reaction of Arylboronic Acids and Heteroarenes. Journal of the American Chemical Society. 135(12):4675. Haddad GL. 2012. Back-​Scattering Interferometry: An Ultrasensitive Method for the Unperturbed Detection of Acetylcholinesterase-​Inhibitor Interactions. Angewandte Chemie, International Edition. 51(44):4. Pesciotta E., D.J. B., Flowers, II R.A.. 2011. Backscattering Interferometry: A Versatile Platform for the Study of Free-Solution vs. Surface Immobilized Hybridization. Chemistry - A European Journal. 6 Pesciotta E., D.J. B., Flowers, II R.A.. 2011. Backscattering Interferometry: an alternative approach for the study of hydrgen bonding interactions in organic solvents. Organic Letters. 13 Choquette K.A, Sadasivam D.V., Flowers, II R.A.. 2011. Catalytic Ni(II) in Reactions of SmI2: Sm(II)- or Ni(0)-Based Chemistry? Journal of the American Chemical Society. 133 Maisano T., Sadasivam D.V., Flowers, II R.A.. 2011. A convenient pathway to Sm(II)-mediated chemistry in acetonitrile. Organic & Biomolecular Chemistry. 9 Young S.C., Fabio K.M., Huange M.-T., Saxena J., Harman M.P., Guillon C.D., Heck D.E., Flowers, II R.A., Heindel N.D., Laskin J.D.. 2011. Investigation of Anticholinergic and Non-steroidal Anti-inflammatory Prodrugs which Reduce Chemically-induced Skin Inflammation. Journal of Applied Toxicology. 292 Casey B.M., Flowers, II R.A.. 2011. On the Nature of Oxidative Coupling of Lithium Enolates. Journal of the American Chemical Society. 133 Teprovich, Jr. J.A., Sadasivam D.V., Procter D.J., Flowers, II R.A.. 2010. Dynamic Ligand Exhange in Reactions of Samarium Diiodide. Org. Lett.. 12 Singh R., Flowers, II R.A.. 2010. Efficient protein renaturation using tunable hemifluorinated anionic surfactants as additives. Chem. Commun.. 46 Devery, III J.J., Conrad J.C., MacMillan D.W.C., Flowers, II R.A.. 2010. Mechanistic Complexity in Organo-SOMO Activation. Angew. Chem., Int. Ed.. 49