Gerber, Nancy - San Francisco State University - Department of Chemistry and Biochemistry

个人简介

B.S. (1988) Univ. of Florida, Physics Ph.D. (1993) Univ. of Illinois, Champaign-Urbana, Biochemistry

研究领域

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Our lab uses biochemical and biophysical techniques to determine the mechanisms involved in the regulation of heme proteins such as soluble guanylate cyclase and cytochrome P450s. Our lab is interested in the mechanisms of action of metalloproteins with particular emphasis on heme proteins. General areas of study include mechanisms of enzyme regulation, control of enzyme specificity including specificity of protein-protein interactions, and the role of conformational changes in the activation of allosteric enzymes. Techniques used include UV/Vis, Fluorescence, and CD spectroscopies, as well as standard heterologous protein expression and purification techniques and cell culture techniques. We are currently studying cytochrome P-450 enzymes that are involved in pesticide and herbicide metabolism, and the nitric oxide receptor soluble guanylyl cyclase.