Billingsley, Kelvin - San Francisco State University - Department of Chemistry and Biochemistry

个人简介

B.S. (2002) Univ. South Carolina, Chemistry Ph.D. (2008) M.I.T., Organic Chemistry Postdoc (2013) Stanford University, Medicinal Chemistry/Radiology

研究领域

The foundation of our research is the development of chemical tools and methods with applications that span from medicinal chemistry to radiological sciences. The lab takes an interdisciplinary approach, combining elements of organic synthesis, catalysis and biology, to address problems of clinical importance. We maintain a fundamental interest in designing metal-catalyzed processes to construct structural motifs embodied in molecules of biological and therapeutic significance. Using such chemical technologies, we are also developing molecular probes for hyperpolarized 13C MR and PET imaging to discover and study new questions in cancer and neurobiology.

近期论文

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Dufert, M. A.; Billingsley, K.; Buchwald, S. L. Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation. J. Am. Chem. Soc. 2013, 135, 12877-12885. Billingsley, K.; Wender, P. A. Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues. Synthesis 2013, 45, 1815-1824. Josan, S.; Hurd, R.; Billingsley, K.; Senadheera. L; Park, J.; Yen, Y.-F.; Pfefferbaum, A.; Spielman, D.; Mayer, D. Effects of Isoflurane Anesthesia on Hyperpolarized 13C Metabolic Measurements in Rat Brain. Magn. Reson. Med. 2012, doi: 10.1002/mrm.24532. Balaconis, M. K.; Billingsley, K.; Dubach, M.; Cash, K. J.; Clark, H. A. The Design and Development of Fluorescent Nano-Optodes for In Vivo Glucose Monitoring. J. Diabetes Sci. Technol. 2011, 5, 1650-1657. Billingsley, K.; Balaconis, M. K.; Dubach, J. M.; Zhang, N.; Lim, E.; Francis, K. P.; Clark, H. A. Fluorescent Nano-Optodes for Glucose Detection. Anal. Chem. 2010, 82, 3707-3013. Billingsley, K.; Buchwald, S. L. A General and Efficient Method for the Suzuki-Miyaura Coupling of 2-Pyridyl Nucleophiles. Angew. Chem. Int. Ed. 2008, 47, 4695-4698. Billingsley, K.; Buchwald, S. L. An Improved System for the Palladium-Catalyzed Borylation of Aryl Halides with Pinacol Borane. J. Org. Chem. 2008, 73, 5589-5591. Billingsley, K.; Barder, T. E.; Buchwald, S. L. Palladium-Catalyzed Borylation of Aryl Chlorides: Scope, Applications, and Computational Studies. Angew. Chem. Int. Ed. 2007, 46, 5359-5363. Billingsley, K.; Buchwald, S. L. Highly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters. J. Am. Chem. Soc. 2007, 129, 3358-3366. Billingsley, K.; Anderson, K. W.; Buchwald, S. L. A Highly Active Catalyst for Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Compounds. Angew. Chem. Int. Ed. 2006, 45, 3484-3488. Brizius, G.; Billingsley, K.; Smith, M. D.; Bunz, U. H. F. Conformational and Electronic Engineering of Twisted Diphenylacetylenes. Org. Lett. 2003, 5, 3951-3954.