Baird, Teaster - San Francisco State University - Department of Chemistry and Biochemistry

研究领域

We are a biochemistry lab in the Chemistry and Biochemistry Department at San Francisco State University. Our research interests are in protein structure-function relationships, particularly substrate specificity, catalysis and inhibition in serine proteases. I have little doubt that you've heard of the serine protease trypsin. It's in every biochemistry text book, it's used in mass spectroscopy studies and it's been studied for over 50 years. Well, in the Baird Lab, we use trypsin as a model system because its scaffold is representative of a number of other serine proteases making our results potentially applicable to more than 100 other enzymes. Because there is so much already known about it, it an excellent system for protein engineering experiments in this family of enzymes and it is relatively easy to mutagenize, express, purify and characterize.

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Batt, A.R., St. Germain, C.P., Gokey, T., Guliaev, A.B., Baird, T. Jr., Engineering trypsin for inhibitor resistance. Protein Science (2015) DOI: 10.002/pro. 2732 Tansey, J.T., Baird, T. Jr., Cox, M. M., Fox, K.M., Knight, J., Sears, D., Bell, E. Foundational concepts and underlying theories for majors in Biochemistry and Molecular Biology Biochem. Mol. Biol. Educ. (2013) 41, 287-296 Baird, T. T., Jr., and Craik, C. S. Trypsin Handbook of Proteolytic Enzymes, 3rd ed. (2013) 2594-2600 Baird, T. T., Jr., Trypsin, Brenner's Encyclopedia of Genetics, 2nd edition (2013) pp. 216-219 Gokey, T., Baird, T.T., Jr., and Guliaev, A.B. Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants J. Mol. Model (2012) 18, 4941-4954 Baird, T.T., Jr., Wright, W. D., and Craik, C. S. Conversion of Trypsin to a Functional Threonine Protease, Prot. Sci., (2006) 15, 1229-1238. Halfon, S., Baird, T.T., Jr., and Craik, C. S. Trypsin Handbook of Proteolytic Enzymes, 2nd ed. (2004) 1483-1488 Baird, T.T., Jr. and Craik, C. S. Trypsin. Encyclopedia of Genetics, Academic Press, London (2001) 2071-2075. Baird, T. T., Jr., Wang, B., Lodder, M., Hecht, S. M., and Craik, C. S. Generation of Active Trypsin with Chemical Cleavage, Tetrahedron Letters (2000) 56(48), 9477-9485 Wang, B., Lodder, M., Baird, T. T., Jr., Brown, K. C., Craik, C. S., and Hecht, S. M. Chemically Mediated Site-Specific Cleavage of Proteins, J. Am. Chem. Soc. (2000) 122, 7402-7403 Doyon, J. B., Hansen, E. A. M., Kim, C.-Y., Chang, J. S., Christianson, D. W., Madder, R. D., Voet, J. G., Baird,T. T., Jr., Fierke, C. A. and Jain, A. Linear Free Energy Relationships Implicate Three Modes of Binding for Fluoroaromatic Inhibitors to a Mutant of Carbonic Anhydrase II, Organic Lett. (2000) 2, 1189-1192. Alber, B. E., Colangelo, C. M., Dong, J., Stålhabdske, C. M. V., Baird, T. T., Tu, C., Fierke, C. A., Silverman, D. N., Scott, R. A. and Ferry, J. G. Kinetic and Spectroscopic Characterization of the Gamma Carbonic Anhydrase from the Methanoarchaeon Methanosarcina thermophila, Biochemistry (1999) 38, pp. 13119-28 Baird, T. T., Jr., Waheed, A., Sly, W. S., and Fierke, C. A. Catalysis and Inhibition of Human Carbonic Anhydrase IV, Biochemistry, (1997) 36 pp. 2669-2678 Ippolito, J.A., Baird, T.T., Jr., McGee, S. A., Christianson, D. W., and Fierke, C. A. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity, Proc. Natl. Acad. Sci. USA, (1995), 92 pp. 5017-5021. Wild, C., Dubay, J. W., Greenwell, T., Baird, T., Jr., Oas, T. G., McDanal, C., Hunter, E., and Matthews, T. Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex. Proc. Natl. Acad. Sci. USA, (1994), 91 pp. 12676-12680 Miller, T. M., Kwock, E. W., Baird, T. Jr., and Hale, A. Properties and Photodefinition of Poly(aromatic diacetylenes). MATERIALS, (1994) 6 pp. 1569-1574 Kwock, E. W., Baird, T., Jr., and Miller, T. M. Synthesis and Characterization of Soluble, High Molecular Weight Poly(aromatic diacetylenes), Macromolecules, (1993), 26 pp. 2935-2940