个人简介

1990–present Professor, Carnegie Mellon University 1978–1990 Professor, University of Minnesota 1979–1981 Acting Director, Gray Freshwater Biological Institute, University of Minnesota 1974–1978 Associate Professor of Biochemistry, University of Minnesota 1972–1974 Assistant Professor of Physics/Biochemistry, University of Illinois 1969–1972 Research Assistant Professor, University of Illinois 1967–1969 Postdoctoral Fellow, University of Illinois 1967 PhD, Technical University Darmstadt, Germany

研究领域

Bioinorganic/Biophysical

High-valent iron complexes We apply Mössbauer and EPR spectroscopy to study systems of biological relevance. We are particularly interested in high-valent intermediates of catalytic reactions. This line of research has recently resulted in the characterization of a variety of novel Fe(IV)-oxo complexes and the first Fe(V)-oxo complex. The spectroscopic data are analyzed with various quantum chemical methods. Magnetochemistry Some of our studies invariably force our attention into magnetochemistry. The unusual magnetic properties of a diiron(I) diketiminate complex, for instance, could only be understood with substantial insights provided by density functional theory, and studies of protein-bound 3Fe-4S clusters led to new insights into magnetochemistry, such as double-exchange and antisymmetric exchange. Metalloproteins and whole cell Mössbauer studies We have recently started to extend our studies of isolated proteins to whole E. coli cells and yeast mitochondria.

近期论文

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Mbughuni, M.; Chakrabarti , M.; Title: Hayden , J.; Bominaar, E. ; Hendrich, M, Münck, E.; Lipscomb, J. "Trapping and spectroscopic characterization of an FeIII -superoxo intermediate from a non-heme mononuclear iron-containing enzyme", Proc. Natl. Acad. Sci. USA 2010, 107, 16788-93. McDonald, A.; Bukowski, M.; Farquhar, E.; Jackson, T.; Koehntop, K. ; Seo, Mi S.; De Hont, R.; Stubna, A.; Halfen, J.; Münck, E.; Nam, W.; Que, L. "Sulfur versus Iron Oxidation in an Iron-Thiolate Model Complex" J. Am. Chem. Soc. 2010, 17118-29. Company, A.; Prat, I.; Frisch J.R.; Ruben Mas Ballesté,R.M.; Güell M.; Juhász G.; Ribas, X.; Eckard Münck,E.; Luis, J. M.; Que, Jr., L.; Miquel Costas M. “Modelling the cis-oxo-labile binding site motif of non-heme iron oxygenases. Water exchange and remarkable oxidation reactivity of a novel non-heme iron(IV)-oxo compound bearing a tripodal tetradentate ligand”, Chem. Eur. J. 2010, in press. Martinho, M.; Münck, E. 2010, "57Fe Mössbauer Spectroscopy in Chemistry and Biology" in Physical Inorganic Chemistry" A. Bakac, ed, Wiley, Inc. Münck, E.; Bominaar, E. L. 2011 “Mössbauer Spectroscopy of Biological Systems” in “The Rudolf Mössbauer Story”, G. M. Kalvius and P. Kienle (editors), Springer Verlag, in press. Bruijnincx PC, Buurmans IL, Huang Y, Juha´sz G, Viciano-Chumillas M, Quesada M, Reedijk J, Lutz M, Spek AL, Münck E, Bominaar EL, Klein Gebbink RJ "Mono- and Dinuclear Iron Complexes of Bis(1-methylimidazol-2-yl)ketone (bik): Structure, Magnetic Properties, and Catalytic Oxidation Studies." Inorg. Chem. 2011, 19, 9243-55. England, J.; Guo, Y.; Van Heuvelen, K. M. Cranswick, M.A., Rohde, G. T.; Bominaal E. L.; Münck, E. Que, L. Jr "A more reactive trigonal-bipyramidal high-spin oxoiron(IV) complex with a cis-labile site." J. Am. Chem. Soc. 2011, 133, 11880-83. Mbughuni, M.; Chakrabarti, M.; Hayden, J.A.; Meier, K. K. , Dalluge, J.J.; Hendrich, M.P.; Münck, E.; Lipscomb, J.D. "Oxy-Intermediates of Homoprotocatechate 2,3 Dioxygenase: Facile Electron Transfer between Substrates" Biochemistry, 2011, 50, 10262-74. Li, F.; Chakrabarti, M.; Dong, Y.; Kauffmann, K.; Bominaar, E. L.; Münck, E.; Que, Jr., L. "Structural, EPR, and Mössbauer characterization of (μ-alkoxo)(μ-carboxylato)diiron(II,III) model complexes for the active sites of mixed-valent diiron enzymes" Inorg. Chem. 2012, 51, 2917-29. Van Heuvelen, K. M.; Fiedler, A. T.; Shan, X.; De Hont, R. F.; Meier, K. K.; Bominaar, E. L.; Münck, E.; Que, Jr., L. "An [O=FeV=NR]+ Center Formed by One-Electron Oxidation of an Oxoiron(IV) Complex" Proc. Natl. Acad. Sci. 2012, 109, 11933-38. Fleischhacker A. S.; Stubna, A.; Hsueh, K. L.; Guo, Y.; Teter, S. J.; Rose, J. C.; Brunold, T. C.; Markley, J. L.; Münck, E.; Kiley, P.J. "Characterization of the [2Fe-2S] Cluster of E. coli Transcription Factor IscR" Biochemistry 2012, 51, 4453-62. McDonald, A. R.; Van Heuvelen, K. M.; Guo, Y.; Bominaar, E. L.; Münck, E.; Que, Jr., L. "Characterization of a Unique Thiolato-Iron(III)-Peroxide Complex" Inorg. Chem. 2012, 51, 2917-29. Cranswick, M. A.; Meier, K. K.; Shan, X. Stubna, A.; Kaizer, J.; Mehn, M. P.; Münck, E.; Que, Jr., L. "Protonation of a peroxodiiron(III) complex and conversion to a diiron(IV) intermediate: Implication for proton assisted O-O bond cleavage in non-heme Diiron enzymes" Inorg. Chem. 2012, 51, 10417-26. Mbughuni, M. M.; Meier, K. K.; Münck, E.; Lipscomb, J. D. "Substrate-Mediated Oxygen Activation by Homoprotocatechuate 2,3-Dioxygenase: Intermediates Formed by a Tyrosine 257 Variant" Biochemistry 2012, 51, 8743-54. Banerjee, R.; Meier, K.K.; Münck, E.; Lipscomb, J.D. "Intermediate P* from Soluble Methane Monooxygenase Contains a Diferrous Cluster" Biochemistry 2013, 52, 4331-42. Li, F.; Van Heuvelen, K.; Meier, K. K.; Münck, E.; Que, Jr., L. "Sc3+-triggered oxoiron(IV) formation from O2 and its nonheme iron(II) precursor via a Sc3+-peroxo-Fe3+ intermediate" J. Am. Chem. Soc. 2013, 135, 10198-201. Stoian, S. A.; Xue, G.; Bominaar, E. L.; Que, Jr., L.; Münck, E.; " Spectroscopic and theoretical investigation of a complex with a [O=FeIV-O-FeIV=O] core related to methane monooxygenase intermediate Q" J. Am. Chem. Soc. 2014, Jan 14. Aukema, K.G.; Makris, T. M.; Stoian, S. A.; Richman, J. E.; Münck, E.; Lipscomb, J. D.; Wackett, L. P. "Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n-1 aldehydes and alcohols in addition to alkanes" ACS Catalysis 2013, 3, 2228-38. Oloo, W. N.; Meier, K. K.; Wang, Y.; Shaik, S.; Münck, E.; Que, Jr., L. "Identification of a low-spin acylperoxoiron(III) intermediate in bio-inspired non-heme iron-catalysed oxidations” Nature Communications 2014, 5, Jan 16 (online). England, J., Bigelow, J. O.; Van Heuvelen, K. M.; Farquhar, E. R.; Martinho, M.; Meier, K. K.; Frisch, J. R.; Münck, E.; Que, Jr., L. "An Ultra-Stable Oxoiron(IV) Complex and its Blue Conjugate Base" , Chemical Science 2013, in press.