Burrus, Laura - San Francisco State University

个人简介

BS in Chemistry - College of William and Mary (1986) PhD in Biochemistry - University of Wisconsin-Madison (1991) Post-doc in Developmental Biology - Harvard University (1996) Dr. Burrus' research is focused on identifying the biochemical and cellular mechanisms underlying Wnt gradient formation in chick embryos. Her work on Wnt signaling is relevant to birth defects as well as cancer and has been funded by NIH, NSF, CSUPERB, and MDA over the last 20 years. Dr. Burrus is also active in pedagogical innovation and is pioneering new approaches to effectively communicate research to scientific and lay communities. As one of five LGBTQIA biology faculty in the Dept of Biology at SFSU, she brings unique perspectives and recently collaborated on research published in 2015 exploring how biology faculty language used in classrooms may influence feelings of inclusivity.

研究领域

Mechanisms Underlying Vertebrate Wnt Gradient Formation: Wnt1 and Wnt3a are morphogens that control proliferation and cell fate specification in the developing chick spinal cord. As the dose of a morphogen controls the downstream responses of target cells, it is critically important to understand how Wnt gradients are formed. Although much is known about the downstream signaling pathways activated by Wnt proteins, little is known about the processing and secretion of Wnt proteins. We are currently investigating the biochemical, cellular and developmental roles of Porcupine and Wntless, two upstream regulators of Wnt secretion and gradient formation. Development of a Biochemical Assay for Wnt Palmitoylation: The palmitoylation of Wnt proteins by Porcupine is critical for Wnt gradient formation. To better understand the biochemistry underlying this critical modification, we need to be able to easily measure Wnt palmitoylation. Unfortunately, the assays that are most often used to measure Wnt palmitoylation are cumbersome and slow. We are using a "click" chemistry based approach to develop an assay that will facilitate the study of Porcupine structure and function. This work is funded by an NSF RUI grant. Investigating the Role of Porcupine in Neural Tube Closure: Defects in neural tube closure are amongst the most common birth defects. Wnt signaling pathways are known to be required for proper neural tube closure. Mutations in Porcupine cause a variety of defects in mouse and human, including possible defects in neural tube closure. We are performing experiments in the chick model system to more fully understand the role of Porcupine in neural tube closure. This work is funded by an NIH AREA grant.

近期论文

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Classroom sound can be used to classify teaching practices in college science courses. Owens MT, Seidel SB, Wong M, Bejines TE, Lietz S, Perez JR, Sit S, Subedar ZS, Acker GN, Akana SF, Balukjian B, Benton HP, Blair JR, Boaz SM, Boyer KE, Bram JB, Burrus LW, Byrd DT, Caporale N, Carpenter EJ, Chan YM, Chen L, Chovnick A, Chu DS, Clarkson BK, Cooper SE, Creech C, Crow KD, de la Torre JR, Denetclaw WF, Duncan KE, Edwards AS, Erickson KL, Fuse M, Gorga JJ, Govindan B, Green LJ, Hankamp PZ, Harris HE, He ZH, Ingalls S, Ingmire PD, Jacobs JR, Kamakea M, Kimpo RR, Knight JD, Krause SK, Krueger LE, Light TL, Lund L, Márquez-Magaña LM, McCarthy BK, McPheron LJ, Miller-Sims VC, Moffatt CA, Muick PC, Nagami PH, Nusse GL, Okimura KM, Pasion SG, Patterson R, Pennings PS, Riggs B, Romeo J, Roy SW, Russo-Tait T, Schultheis LM, Sengupta L, Small R, Spicer GS, Stillman JH, Swei A, Wade JM, Waters SB, Weinstein SL, Willsie JK, Wright DW, Harrison CD, Kelley LA, Trujillo G, Domingo CR, Schinske JN, Tanner KD. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3085-3090. doi: 10.1073/pnas.1618693114. Epub 2017 Mar 6. The Use of Chick Embryos to Study Wnt Activity Gradients. Galli LM, Barnes T, Burrus LW. Methods Mol Biol. 2016;1481:69-80. doi: 10.1007/978-1-4939-6393-5_8. Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling. Galli LM, Zebarjadi N, Li L, Lingappa VR, Burrus LW. Exp Cell Res. 2016 Sep 10;347(1):171-83. doi: 10.1016/j.yexcr.2016.07.028. Epub 2016 Aug 1. Beyond the Biology: A Systematic Investigation of Noncontent Instructor Talk in an Introductory Biology Course. Seidel SB, Reggi AL, Schinske JN, Burrus LW, Tanner KD. CBE Life Sci Educ. 2015 Winter;14(4):ar43. doi: 10.1187/cbe.15-03-0049. Identification of the WNT1 residues required for palmitoylation by Porcupine. Miranda M, Galli LM, Enriquez M, Szabo LA, Gao X, Hannoush RN, Burrus LW. FEBS Lett. 2014 Dec 20;588(24):4815-24. doi: 10.1016/j.febslet.2014.11.016. Epub 2014 Nov 20. Concentration-dependent effects of WNTLESS on WNT1/3A signaling. Galli LM, Szabo LA, Li L, Htaik YM, Onguka O, Burrus LW. Dev Dyn. 2014 Sep;243(9):1095-105. doi: 10.1002/dvdy.24149. Epub 2014 Jun 25. Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo. Galli LM, Munji RN, Chapman SC, Easton A, Li L, Onguka O, Ramahi JS, Suriben R, Szabo LA, Teng C, Tran B, Hannoush RN, Burrus LW. Dev Dyn. 2014 Jun;243(6):833-43. doi: 10.1002/dvdy.24123. Epub 2014 Apr 1. Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences. Galli LM, Burrus LW. PLoS One. 2011;6(10):e26636. doi: 10.1371/journal.pone.0026636. Epub 2011 Oct 26.