研究领域

Natural Product Chemistry, Synthetic Organic Chemistry, Chemical Biology

Selection of Biologically Active Compounds from a Synthetic Library keyword : Biological Activity 2013.04～2015.03. Mode of action study of ladder-shaped polyethers keyword : ladder-shaped polyether, chemical biology, natural product chemistry, synthetic organic chemistry, flow-micro synthesis 2010.11～2013.03. Development of a Novel Protective Group and Its Application to the Total Synthesis of Natural Products keyword : Protective Groups 2014.04～2016.03.

近期论文

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Torikai, K., Suga, H.*,Ribosomal Synthesis of an Amphotericin-B Inspired Macrocycle,J. Am. Chem. Soc.,Vol.136,2014.12 [URL]. Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M., Oishi, T.*,Synthesis and Biological Activity of the QRS Ring System of Maitotoxin,Chem. Lett.,Vol.43,2014.09. Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M., Oishi, T.*,Synthesis and Biological Activity of the C'D'E'F' Ring System of Maitotoxin,J. Org. Chem.,Vol.79,2014.05. Kajitani, K., Koshiyama, T., Hori, A., Ohtani, R., Mishima, A., Torikai, K., Ebine, M., Oishi, T., Takata, M., Kitagawa, S., Ohba, M.*,Guest Responsivity of a Two-Dimensional Coordination Polymer Incorporating a Cholesterol-Based Co-Ligand ,Dalton Trans.,Vol.42,2013.07. Nakashima, T., Baba, T., Onoue, H., Yamashita, W., Torikai, K.*,A Facile and Practical Synthesis of Nicolaou’s Key Intermediates, 2-Methyl- and 2,6-Dimethyl-Tetrahydropyrans, toward the Total Synthesis of Ladder-Shaped Polyethers,Synthesis,Vol.45,2013.09. Oishi, T.*; Konoki, K.; Tamate, R.; Torikai, K.; Hasegawa, F.; Matsumori, N.; Murata, M.,Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells,Bioorg. Med. Chem. Lett.,Vol.22,pp.3619-3622,2012.04. Torikai, K.*; Saruwatari, T.; Kitano, T.; Sano, T.; Nakane, A.; Noguchi, H.; Watanabe, K.,Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743,Lett. Org. Chem.,Vol.8,pp.686-689,2011.12. . Goto, Y., Iwasaki, K., Torikai, K., Murakami, H., Suga, H.*,Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides,Chem. Commun. ,pp.3419,2009.04. Mouri, R.; Oishi, T.*; Torikai, K.; Ujihara, S.; Matsumori, N.; Murata, M.*; Oshima, Y.,Surface plasmon resonance-based detection of ladder-shaped polyethers by inhibition detection method,Bioorg. Med. Chem. Lett.,Vol.19,pp.2824,2009.03. Kimura, H.*; Torikai, K.; Ueda, I.,Thermal cyclization of nonconjugated aryl-yne-carbodiimide furnishing a dibenzonaphthyridine derivative,Chem. Pharm. Bull.,Vol.57,pp.393,2009.01. Ujihara, S.; Oishi, T.*; Torikai, K.; Konoki, K.; Matsumori, N.; Murata, M.*; Oshima, Y.; Aimoto, S.,Interaction of ladder-shaped polyethers with transmembrane a-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance,Bioorg. Med. Chem. Lett.,Vol.18,pp.6115,2008.10. Torikai, K.; Watanabe, K.; Minato, H.; Imaizumi, T.; Murata, M.; Oishi, T.*,Convergent synthesis of the A-J ring system of yessotoxin,Synlett,pp.2368,2008.08. Torikai, K.; Oishi, T.*; Ujihara, S.; Matsumori, N.; Konoki, K.; Murata, M.; Aimoto, S. ,Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins,J. Am. Chem. Soc.,Vol.130,pp.10217,2008.07. Oishi, T.*; Hasegawa, F.; Torikai, K.; Konoki, K.; Matsumori, N.; Murata, M. ,Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin,Org. Lett.,Vol.10,pp.3599,2008.06. Kimura, H.*; Torikai, K.; Miyawaki, K.; Ueda, I.,Scope of the thermal cyclization of non-conjugated ene-yne-nitrile system: A facile synthesis of cyanofluorenol derivatives,Chem. Lett.,Vol.37,pp.662,2008.05. Torikai, K.*; Otsuka, Y.; Nishimura, M.; Sumida, M.; Kawai, T.; Sekiguchi, K.; Ueda, I.,Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes,Bioorg. Med. Chem.,Vol.16,pp.5441,2008.04. Torikai, K.; Yari, H.; Murata, M.; Oishi, T.*,Synthesis of artificial ladder-shaped polyethers containing a 6/7 cis-fused ring system,Heterocycles,Vol.70,pp.161,2006.11. Torikai, K.; Yari, H.; Mori, M.; Ujihara, S.; Matsumori, N.; Murata, M.; Oishi, T.*,Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A,Bioorg. Med. Chem. Lett.,No.16,pp.6355,2006.09.