Mueller, Casey - California State University, San Marcos

个人简介

The theme throughout my research career has been comparative developmental physiology. My research projects have included the investigation of the trajectory of the development of organ systems, the interactions between developing organ systems, and the times when the systems are most susceptible to environmental stressors. These areas of research are at the forefront of current developmental physiological research. I completed my PhD in 2011 in the lab of Dr. Roger Seymour at the University of Adelaide, Australia. My PhD research focused on respiratory physiology during the development of amphibians and the Australian lungfish. In the first physiological studies on Australian lungfish embryos, I found that temperature and oxygen level affected development, gas exchange, metabolism and energetic costs during development. I utilised novel mathematical approaches to relate differences in development rates of two amphibians to their energy partitioning, and I quantified for the first time the role of egg perivitelline fluid in oxygen uptake of amphibian embryos. During my postdoctoral research position (2011-2013) in Dr. Warren Burggren's Developmental Physiology lab at the University of North Texas, USA, my research included investigation of the cardiovascular, renal and acid-base systems of avian (chicken) and reptilian (alligator) embryos. I utilised both environmental and pharmacological stressors to examine the development and interactions of physiological systems. As part of my growing interest in developmental trajectories and critical windows, I also developed experiments to examine the effect of exposure to differing salinity levels at particular time points during brine shrimp development. This work is novel as it takes a new approach to examining developmental critical windows, examining not just when the critical windows are present but the more detailed nuances of stressor dose responses and the magnitude of the effect within the window. I completed a postdoctoral fellowship (2013-2015) at McMaster University, supervised by Dr. Joanna Wilson. In collaboration with Dr. John Eme, I used different thermal regimes to examine plasticity in the developmental trajectory, growth and metabolism of lake whitefish embryos. This work expanded my research on critical windows by investigating if developmental metabolism is more susceptible to a temperature change at certain critical developmental time points. In Fall 2015 I began as an Assistant Professor in the Department of Biological Sciences at California State University San Marcos. The focus of the Mueller lab is to explore the interaction between the environment and developmental physiology in invertebrates, fishes and amphibians found in California. I am enjoying working with students at CSUSM to answer a broad range of questions in the realm of comparative developmental physiology.

近期论文

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21. Mueller, C.A., Tazawa, H. and Burggren, W.W. (2017) Dynamics of acid-base and hematological regulation in day 15 chicken embryos (Gallus gallus domesticus) exposed to graded hypercapnia and hypoxia. Respiratory Physiology and Neurobiology 239, 55-63 doi: 10.1016/j.resp.2017.02.001 20. Mueller, C.A., Doyle, L., Eme, J., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2017) Lipid content and fatty acid profile during lake whitefish embryo development at different incubation temperatures. Comparative Biochemistry and Physiology A 203, 201-209. doi: 10.1016/j.cbpa.2016.09.018 19. Lee, A.H. Eme, J., Mueller, C.A., Manzon, R.G., Rogers, C.M., Boreham, D.R. and Wilson, J.Y. (2016) The effects of cumulative acute heat shock exposures on morphology and survival of Lake whitefish (Coregonus clupeaformis) embryos. Journal of Thermal Biology 57, 11-20. doi:10.1016/j.jtherbio.2016.01.010 18. Mueller, C.A., Willis, E., Burggren, W.W. (2016) Salt sensitivity of the morphometry of Artemia franciscana during development: A demonstration of 3-D critical windows. Journal of Experimental Biology 219, 571-581. doi:10.1242/jeb.125823 17. Sreetharan, S., Thome, C.*, Mitz, C.*, Eme, J., Mueller, C.A., Hulley, E.N., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2015) Embryonic development of lake whitefish (Coregonus clupeaformis): a staging series, analysis of growth and impacts of fixation. Journal of Fish Biology 87, 539-558. doi:10.1111/jfb.12725 16. Burggren, W.W., Mueller, C.A., Tazawa, H. (2015) Hypercapnic thresholds for embryonic acid-base metabolic compensation and hematological regulation during CO2 challenges in layer and broiler chicken strains. Respiratory Physiology and Neurobiology 215, 1-12. doi:10.1016/j.resp.2015.04.008 15. Mueller, C.A., Eme, J., Burggren, W.W., Roghair, R.D., Rundle, S.D. (2015) Challenges and opportunities in developmental integrative physiology. Comparative Biochemistry and Physiology A 184, 113-124. doi:10.1016/j.cbpa.2015.02.013 14. Mueller, C.A., Eme, J., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2015) Embryonic critical windows: Changes in incubation temperature alter survival, hatchling phenotype and cost of development in Lake whitefish (Coregonus clupeaformis). Journal of Comparative Physiology B 185, 315-331. doi:10.1007/s00360-015-0886-8 13. Burggren, W.W., Mueller, C.A. (2015) Developmental critical windows and sensitive periods as 3-D constructs in time and space. Physiological and Biochemical Zoology 88, 91-102 (Invited Perspective). doi:10.1086/679906 12. Eme, J., Mueller, C.A., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2015) Critical windows in embryonic development: Shifting incubation temperatures alter heart rate and oxygen consumption of Lake Whitefish (Coregonus clupeaformis) embryos and hatchlings. Comparative Biochemistry and Physiology A 179, 71-80. doi:10.1016/j.cbpa.2014.09.005