Horner , Angela - California State University, San Bernardino

个人简介

My research and lab group are focused on the mechanisms that shape locomotor strategies in animals, and how proximate (e.g., traversing different environments) and longer-term (e.g., aging, disease) perturbations may affect performance. My past research has investigated the interplay of substrate and locomotion in a variety of vertebrates, including lungfish, rodents, and ferrets. Since joining CSUSB as an Assistant Professor of Biology in September of 2013, I have focused my research on muscle function in small mammals. Although small mammals such as rats and mice have frequently been used as research models, the integrated in vivo function of muscles and tendons in crouched mammals is still not well understood.

研究领域

Functional anatomy and muscle physiology constitute the broad themes of my research interests, particularly how tissue level traits impact the whole organism. I seek to broadly integrate anatomy (e.g., body shape, bone mechanical properties, muscle fiber type) with function (e.g., locomotor gait) and performance (e.g., VO2 max, muscle force production) across organizational levels. By measuring traits such as muscle activity, energetic cost of locomotion, gait, posture, and center of mass dynamics in model organisms I can integrate multiple levels of organization. My graduate work spanned a morphologically diverse array of taxa, including lungfish, ferrets, degus, guinea pigs, and rats. I investigated environmental determinants of locomotor performance, such as the effects of viscosity on the motor pattern and kinematics of swimming lungfish, and how the constraints of tunnels affect locomotor performance in a range of small mammals. Currently I focus on small mammals to better understand the interaction of muscle and bone tissue mechanical properties on whole organism performance. I am interested in pursuing clinical disease and pathology models, as I believe these naturally occurring perturbations offer insight into basic musculoskeletal function, and conversely the wide array of techniques I have used in comparative studies can offer new perspectives to clinical studies. This creative intersection of comparative and clinical biology has the potential to further both fields, particularly in terms of methodological approaches and the use of novel organismal models. My postdoctoral work largely focused on tissue mechanical changes and locomotor performance as a function of age, a topic I continue to investigate actively now with funding from the NSF (Engineering Biomechanics and Mechanobiology division).

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Falkingham, P.L. and A.M. Horner, Trackways Produced by Lungfish During Terrestrial Locomotion. Nature Scientific Reports, 2016. 6: p. 33734. Horner, A. M., Hanna, J. B., & Biknevicius, A. R. (2016). Crouching to fit in: the energetic cost of locomotion in tunnels. Journal of Experimental Biology, jeb-132449. Camp, A. L., Astley, H. C., Horner, A. M., Roberts, T. J., Brainerd, E. L., 2016. Fluoromicrometry: A Method for Measuring Muscle Length Dynamics with Biplanar Videofluoroscopy. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 00, 1-10. DOI: 10.1002/jez.2031 Bonnan, M. F., Shulman, J., Varadharajan, R., Gilbert, C., Wilkes, M., Horner, A., & Brainerd, E. (2016). Forelimb Kinematics of Rats Using XROMM, with Implications for Small Eutherians and Their Fossil Relatives. PloS one, 11(3), e0149377. Horner, Angela M., and Bruce C. Jayne. “Lungfish axial muscle function and the vertebrate water to land transition.” PloS one 9.5 (2014): e96516. doi: 10.1371/journal.pone.0096516 Horner, Angela M., Sabine Moritz, and Nicolai Konow. “Cutting the cost of crouching: Over-ground and tunnel locomotion in a tunnel specialist.” The FASEB Journal 27.1 Supplement (2013): 79-5. Patel B.A., Horner A.M., Thompson N.E., Barrett L., Henzi S.P. (2013). Ontogenetic Scaling of Fore- and Hind Limb Posture in Wild Chacma Baboons (Papio hamadryas ursinus). PLoS ONE 8(7), e71020. doi:10.1371/journal.pone.0071020 Horner, Angela M., David W. Russ, and Audrone R. Biknevicius. “Effects of early-stage aging on locomotor dynamics and hindlimb muscle force production in the rat.” Journal of Experimental Biology 214.21 (2011): 3588-3595. doi: 10.1242/jeb.055087 Horner, Angela M., and Audrone R. Biknevicius. “A comparison of epigean and subterranean locomotion in the domestic ferret (Mustela putorius furo: Mustelidae: Carnivora).” Zoology 113.3 (2010): 189-197. doi:10.1016/j.zool.2009.11.001 Russ, D. W., Horner, A., Biknevicius, A., & Ward, C. W. (2009). Hindlimb Muscle Quality And Ambulation In Old Rats: 2859. Medicine & Science in Sports & Exercise, 41(5), 483. Horner, Angela M., and Bruce C. Jayne. “The effects of viscosity on the axial motor pattern and kinematics of the African lungfish (Protopterus annectens) during lateral undulatory swimming.” Journal of Experimental Biology 211.10 (2008): 1612-1622. doi: 10.1242/jeb.013029 Horner, Angela M., and Audrone R. Biknevicius. “Fossorial locomotion in a fossorial specialist: The kinematics and kinetics of the ferret (Mustela putotius furo).” JOURNAL OF MORPHOLOGY. Vol. 268. No. 12. DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA: WILEY-LISS, 2007.